Effect of asthma control on general health-related quality of life in patients diagnosed with adult-onset asthma

Abstract Health-related quality of life (HRQoL) is a well-established aspect of health that can be measured by both disease-specific and general instruments. The effect of uncontrolled asthma on generic HRQoL has not been shown in patients with clinically confirmed adult-onset asthma and with asthma control defined according to the Global Initiative for Asthma, so the aim of this study was to determine this. In the 12-year follow-up cohort of the Seinäjoki Adult Asthma Study (n = 203), patients with uncontrolled and partially controlled asthma had lower generic HRQoL as determined by 15D compared to the controlled group. On 10 out of 15 dimensions of 15D, the mean scores were significantly lower in patients with uncontrolled asthma compared with those with controlled asthma. The affected dimensions were mobility, breathing, sleeping, usual activities, mental function, discomfort and symptoms, depression, distress, vitality and sexual activity. In the Tobit regression analysis, a poorer 15D score was associated with uncontrolled asthma, lower postbronchodilator FEV1, female sex, depression, treated dyspepsia and poorer 15D score at diagnosis. Our results show that uncontrolled asthma affects everyday life in several aspects, including previously unknown components such as sexual activity and vitality.

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Development and psychometric evaluation of a health-related quality of life instrument for individuals with adult-onset hearing loss

International Journal of Audiology ◽

10.3109/14992027.2016.1166397 ◽

2016 ◽

Vol 55 (7) ◽

pp. 381-391 ◽

Cited By ~ 3

Author(s):

Carren J. Stika ◽

Ron D. Hays

Keyword(s):

Quality Of Life ◽

Hearing Loss ◽

Psychometric Evaluation ◽

Adult Onset ◽

Health Related Quality ◽

Life Instrument ◽

Related Quality ◽

Health Related

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Generic Health-Related Quality of Life after Repair of Esophageal Atresia and Its Determinants within a German–Swedish Cohort

European Journal of Pediatric Surgery ◽

10.1055/s-0038-1672144 ◽

2018 ◽

Vol 29 (01) ◽

pp. 075-084 ◽

Cited By ~ 5

Author(s):

Sofie Flieder ◽

Michaela Dellenmark-Blom ◽

Stefanie Witt ◽

Carmen Dingemann ◽

Julia Quitmann ◽

...

Keyword(s):

Quality Of Life ◽

Esophageal Atresia ◽

Healthy Population ◽

Health Related Quality ◽

German Sample ◽

Generic Hrqol ◽

Related Quality ◽

Health Related ◽

Pedsql 4.0

Aim Despite advances of outcomes of esophageal atresia (EA), knowledge on patients' health-related quality of life (HRQoL) is sparse. Due to the heterogeneity of EA, larger cohorts need to be investigated to ensure reliability of data. Aim was to determine generic HRQoL after EA repair in a Swedish–German cohort. Patients and Methods Ethical approval was obtained. A total of 192 patients (2–18 years; 134 Swedish; 58 German) were included. Clinical data were reviewed. EA was classified in “severe” and “mild/moderate.” Pediatric Quality of Life Inventory 4.0 Generic Core Scale (PedsQL 4.0) was used in appropriate versions (2–7 years; 8–18 years; self- [SR] and proxy report [PR]) to determine generic HRQoL. Results Swedish and German samples were clinically and demographically comparable. HRQoL was lower in “severe EA” versus “mild/moderate” (2–18 years; total score; PR 85.6 vs. 73.6; p < 0.001) and Gross A versus Gross C type EA (2–7 years; total score; PR 61.0 vs. 79.3; p = 0.035). Total HRQoL was higher in the Swedish versus German sample (2–18 years; total score; PR 82.3 vs. 72.7; p = 0.002). HRQoL was impaired in the German sample versus healthy population (2–18 years; total score; PR 72.7 vs. 82.7; p = 0.001). In German patients (8–18 years), HRQoL was higher in SR versus PR (80.7 vs. 74.7; p = 0.044). Patients' age and presence of VACTERL association or isolated anorectal malformations did not affect HRQoL. Various differences were detected regarding different dimensions of PedsQL 4.0. Conclusion In this first international study, we found several differences in perception of generic HRQoL. HRQoL appears to be determined by the type of EA and severity rather than patients' age or the presence of typical associated malformations. Country-specific differences may be culturally dependent, but further investigations are suggested. A condition-specific instrument validated for EA may provide additional insights.

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Health-related quality of life in patients undergoing hemodialysis

Vojnosanitetski pregled ◽

10.2298/vsp160511211m ◽

2018 ◽

Vol 75 (3) ◽

pp. 246-252

Author(s):

Gora Miljanovic ◽

Milan Marjanovic ◽

Sonja Radakovic ◽

Miljojko Janosevic ◽

Tatjana Mraovic ◽

...

Keyword(s):

Quality Of Life ◽

Renal Disease ◽

Sexual Activity ◽

Chronic Renal Disease ◽

World Health ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Normal Controls

Background/Aim. Chronic renal disease is one of the growing problems all over the world. Health-related quality of life (HRQoL) is an important indicator for those with a chronic disease, such as chronic renal disease, because it may serve as predictor of mortality and hospitalization. The aim of this study was to assess HRQoL in patients on chronic maintenance hemodialysis (HD), and compare it with patients suffering from hypertension (HTA), and normal controls of the same age and gender (C). Methods. The study enrolled 224 males and females older than 18 years: 67 in the HD group, 78 in the HTA group, and 79 in the C group. HRQoL was assessed in all groups using 15-D questionnaire. Results. Significantly higher level of education was recorded in the HD group compared to other two groups. In the HD group there were significantly less employed persons (9%) and significantly more retired (67.2%). All groups were similar regarding an average monthly income and marital status. We found significantly lower total HRQoL score in patients in the HD group, compared to normal controls (0.78 ? 0.16 vs. 0.89 ? 0.10 in the HTA and 0.95 ? 0.06 in the C group) as well as specific scores in almost all investigated domains, except in speech, eating and mental functions. Patients in the HD and HTA groups had similar self-reported quality of life in additional 3 domains: hearing, elimination and distress, while the HD group reported significantly lower scores in remaining 9 domains: mobility, vision, breathing, sleeping, usual activities, discomfort and symptoms, depression, vitality and sexual activity. Patients in the HTA group had significantly lower scores than normal controls in 8 domains (hearing, sleeping, elimination, usual activities, discomfort and symptoms, depression, distress and vitality) as well as in total quality of life, while in remaining 4 domains there was no significant difference (mobility, vision, breathing, sexual activity). Conclusion. Both investigated chronic diseases lead to impairment of HRQoL, which is substantially stronger in hemodialysis than in hypertension. Considering the relationship between depression and HRQoL measures, it may be useful to treat depression of HD patients in order to improve their quality of life.

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The Relationship Between Asthma Control, Impact Of Co-morbid Rhinitis And Health Related Quality Of Life: A Real Life Study.

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2008.12.604 ◽

2009 ◽

Vol 123 (2) ◽

pp. S161-S161

Author(s):

F. Braido ◽

I. Baiardini ◽

S. Balestracci ◽

V. Ghiglione ◽

E. Stagi ◽

...

Keyword(s):

Quality Of Life ◽

Asthma Control ◽

Real Life ◽

Health Related Quality ◽

Life Study ◽

Related Quality ◽

Health Related ◽

Real Life Study ◽

The Relationship

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The effect of adjustable dosing with budesonide/formoterol on health-related quality of life and asthma control compared with fixed dosing

Current Medical Research and Opinion ◽

10.1185/030079903125004303 ◽

2004 ◽

Vol 20 (8) ◽

pp. 1209-1220 ◽

Cited By ~ 30

Author(s):

R. Buhl ◽

P. Kardos ◽

K. Richter ◽

W. Meyer-Sabellek ◽

B. Brüggenjürgen ◽

...

Keyword(s):

Quality Of Life ◽

Asthma Control ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Is Health-Related Quality of Life Associated with Upper and Lower Airway Inflammation in Asthmatics?

BioMed Research International ◽

10.1155/2013/539290 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Nicola Scichilone ◽

Fulvio Braido ◽

Salvatore Taormina ◽

Elena Pozzecco ◽

Alessandra Paternò ◽

...

Keyword(s):

Quality Of Life ◽

Airway Inflammation ◽

Asthma Control ◽

Test Collection ◽

Health Related Quality ◽

Bronchial Inflammation ◽

Related Quality ◽

Health Related ◽

Lower Airways

Background.Allergic diseases impair health-related quality of life (HR-QoL). However, the relationship between airway inflammation and HR-QoL in patients with asthma and rhinitis has not been fully investigated. We explored whether the inflammation of upper and lower airways is associated with HR-QoL.Methods.Twenty-two mild allergic asthmatics with concomitant rhinitis (10 males, 38 ± 17 years) were recruited. The Rhinasthma was used to identify HR-QoL, and the Asthma Control Test (ACT) was used to assess asthma control. Subjects underwent lung function and exhaled nitric oxide (eNO) test, collection of exhaled breath condensate (EBC), and nasal wash.Results.The Rhinasthma Global Summary score (GS) was 25 ± 11. No relationships were found between GS and markers of nasal allergic inflammation (% eosinophils: , ; ECP: , ) or bronchial inflammation (pH of the EBC: , ; bronchial NO: , ; alveolar NO: , ). The mean ACT score was 18. When subjects were divided into controlled (ACT ≥ 20) and uncontrolled (ACT < 20), the alveolar NO significantly correlated with GS in uncontrolled asthmatics (, ).Conclusions.Upper and lower airways inflammation appears unrelated to HR-QoL associated with respiratory symptoms. These preliminary findings suggest that, in uncontrolled asthma, peripheral airway inflammation could be responsible for impaired HR-QoL.

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