scholarly journals Is Health-Related Quality of Life Associated with Upper and Lower Airway Inflammation in Asthmatics?

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Nicola Scichilone ◽  
Fulvio Braido ◽  
Salvatore Taormina ◽  
Elena Pozzecco ◽  
Alessandra Paternò ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Airway Inflammation ◽  
Asthma Control ◽  
Test Collection ◽  
Health Related Quality ◽  
Bronchial Inflammation ◽  
Related Quality ◽  
Health Related ◽  
Lower Airways

Background.Allergic diseases impair health-related quality of life (HR-QoL). However, the relationship between airway inflammation and HR-QoL in patients with asthma and rhinitis has not been fully investigated. We explored whether the inflammation of upper and lower airways is associated with HR-QoL.Methods.Twenty-two mild allergic asthmatics with concomitant rhinitis (10 males, 38 ± 17 years) were recruited. The Rhinasthma was used to identify HR-QoL, and the Asthma Control Test (ACT) was used to assess asthma control. Subjects underwent lung function and exhaled nitric oxide (eNO) test, collection of exhaled breath condensate (EBC), and nasal wash.Results.The Rhinasthma Global Summary score (GS) was 25 ± 11. No relationships were found between GS and markers of nasal allergic inflammation (% eosinophils: , ; ECP: , ) or bronchial inflammation (pH of the EBC: , ; bronchial NO: , ; alveolar NO: , ). The mean ACT score was 18. When subjects were divided into controlled (ACT ≥ 20) and uncontrolled (ACT < 20), the alveolar NO significantly correlated with GS in uncontrolled asthmatics (, ).Conclusions.Upper and lower airways inflammation appears unrelated to HR-QoL associated with respiratory symptoms. These preliminary findings suggest that, in uncontrolled asthma, peripheral airway inflammation could be responsible for impaired HR-QoL.

The effect of adjustable dosing with budesonide/formoterol on health-related quality of life and asthma control compared with fixed dosing

2004 ◽  
Vol 20 (8) ◽  
pp. 1209-1220 ◽  
Author(s):  
R. Buhl ◽  
P. Kardos ◽  
K. Richter ◽  
W. Meyer-Sabellek ◽  
B. Brüggenjürgen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Effect of asthma control on general health-related quality of life in patients diagnosed with adult-onset asthma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Pinja Ilmarinen ◽  
Hind Juboori ◽  
Leena E. Tuomisto ◽  
Onni Niemelä ◽  
Harri Sintonen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sexual Activity ◽  
Asthma Control ◽  
Adult Onset ◽  
Health Related Quality ◽  
Uncontrolled Asthma ◽  
Generic Hrqol ◽  
Related Quality ◽  
Health Related

Abstract Health-related quality of life (HRQoL) is a well-established aspect of health that can be measured by both disease-specific and general instruments. The effect of uncontrolled asthma on generic HRQoL has not been shown in patients with clinically confirmed adult-onset asthma and with asthma control defined according to the Global Initiative for Asthma, so the aim of this study was to determine this. In the 12-year follow-up cohort of the Seinäjoki Adult Asthma Study (n = 203), patients with uncontrolled and partially controlled asthma had lower generic HRQoL as determined by 15D compared to the controlled group. On 10 out of 15 dimensions of 15D, the mean scores were significantly lower in patients with uncontrolled asthma compared with those with controlled asthma. The affected dimensions were mobility, breathing, sleeping, usual activities, mental function, discomfort and symptoms, depression, distress, vitality and sexual activity. In the Tobit regression analysis, a poorer 15D score was associated with uncontrolled asthma, lower postbronchodilator FEV1, female sex, depression, treated dyspepsia and poorer 15D score at diagnosis. Our results show that uncontrolled asthma affects everyday life in several aspects, including previously unknown components such as sexual activity and vitality.

scholarly journals Targeting treatable traits in severe asthma: a randomised controlled trial

2019 ◽  
Vol 55 (3) ◽  
pp. 1901509 ◽  
Author(s):  
Vanessa M. McDonald ◽  
Vanessa L. Clark ◽  
Laura Cordova-Rivera ◽  
Peter A.B. Wark ◽  
Katherine J. Baines ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Randomised Controlled Trial ◽  
Asthma Control ◽  
Severe Asthma ◽  
Controlled Trial ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Randomised Controlled

RationaleTreatable traits have been proposed as a new paradigm for airway disease management.ObjectivesTo characterise treatable traits in a severe asthma population and to determine the efficacy of targeting treatments to these treatable traits in severe asthma.MethodsParticipants (n=140) with severe asthma were recruited to a cross-sectional study and underwent a multidimensional assessment to characterise treatable traits. Eligible participants with severe asthma (n=55) participated in a 16-week parallel-group randomised controlled trial to determine the feasibility and efficacy of management targeted to predefined treatable traits, compared to usual care in a severe asthma clinic. The patient-reported outcome of health-related quality of life was the trial's primary end-point.Main resultsParticipants with severe asthma had a mean±sd of 10.44±3.03 traits per person, comprising 3.01±1.54 pulmonary and 4.85±1.86 extrapulmonary traits and 2.58±1.31 behavioural/risk factors. Individualised treatment that targeted the traits was feasible and led to significantly improved health-related quality of life (0.86 units, p<0.001) and asthma control (0.73, p=0.01).ConclusionsMultidimensional assessment enables detection of treatable traits and identifies a significant trait burden in severe asthma. Targeting these treatable traits using a personalised-medicine approach in severe asthma leads to improvements in health-related quality of life, asthma control and reduced primary care acute visits. Treatable traits may be an effective way to address the complexity of severe asthma.

Asthma Control and Health-Related Quality of Life in ECRHS II.

2009 ◽  
Author(s):  
V Siroux ◽  
A Boudier ◽  
L Cazzoletti ◽  
R de Marco ◽  
C Janson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Asthma control, lung function, nutritional status, and health-related quality of life: differences between adult males and females with asthma

2018 ◽  
Vol 44 (4) ◽  
pp. 273-278 ◽  
Author(s):  
Gabriele Carra Forte ◽  
Maria Luiza Hennemann ◽  
Paulo de Tarso Roth Dalcin
Keyword(s):  
Quality Of Life ◽  
Lung Function ◽  
Nutritional Status ◽  
Asthma Control ◽  
Health Related Quality ◽  
Asthma Patients ◽  
Related Quality ◽  
Health Related ◽  
Males And Females

ABSTRACT Objective: To evaluate health-related quality of life in asthma patients treated at a referral center in southern Brazil, identifying differences between male and female patients, as well as to evaluate differences between the males and females in terms of asthma control, lung function, and nutritional status. Methods: This was a cross-sectional study involving patients ≥ 18 years of age treated at an asthma outpatient clinic. We evaluated clinical parameters, lung function, nutritional status, and quality of life. Results: A total of 198 patients completed the study. The mean age was 56.2 ± 14.8 years, and 81.8% were female. The proportion of patients with uncontrolled asthma was higher among females than among males (63.0% vs. 44.4%; p = 0.041). The body mass index (BMI) and percentage of body fat were higher in females than in males (30.2 ± 5.8 kg/m2 vs. 26.9 ± 4.5 kg/m2 and 37.4 ± 6.4% vs. 26.5 ± 7.4%; p = 0.002 and p < 0.001, respectively). Quality of life was lower in females than in males in the following domains: symptoms (3.8 ± 1.5 vs. 4.6 ± 1.7; p = 0.006); activity limitation (3.6 ± 1.3 vs. 4.4 ± 1.5; p = 0.001); emotional function (3.6 ± 1.9 vs. 4.5 ± 1.7; p = 0.014); and environmental stimuli (3.2 ± 1.6 vs. 4.3 ± 1.9; p = 0.001). Conclusions: Male asthma patients appear to fare better than do female asthma patients in terms of health-related quality of life, asthma control, BMI, percentage of body fat, and comorbidities.

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