scholarly journals Spleen Stiffness as Predictor of Esophageal Varices in Cirrhosis of Different Etiologies

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Carmen Fierbinteanu-Braticevici ◽  
Laura Tribus ◽  
Razvan Peagu ◽  
Ana Petrisor ◽  
Cristian Baicus ◽  
...  
Keyword(s):  
Esophageal Varices ◽  
Acoustic Radiation ◽  
Liver Stiffness ◽  
Radiation Force ◽  
Abdominal Ultrasound ◽  
Acoustic Radiation Force Impulse ◽  
P Value ◽  
Upper Gastrointestinal Endoscopy ◽  
Spleen Stiffness ◽  
Excellent Method

Abstract The purpose of this study is to determine whether esophageal varices (EV) can be identified through the evaluation of spleen stiffness (SSM) via acoustic radiation force impulse (ARFI). A total of 135 patients suffering from cirrhosis underwent a clinical exam, laboratory tests, abdominal ultrasound, liver stiffness (LSM) measurement, SSM evaluation and upper gastrointestinal endoscopy. Based on the endoscopy results, the patients were classified into three groups: those with no evident EV, those with small EV and those with varices needing treatment (VNT). Patients with EV of any grade had significantly higher average SSM values over those with no EV (3.37 m/s versus 2.79 m/s, p-value < 0.001), while patients with VNT showed an even greater difference (3.96 m/s versus 2.93 m/s, p-value < 0.001). SSM proved to be an excellent method of predicting patients with VNT.

scholarly journals The role of spleen stiffness using ARFI in predicting esophageal varices in patients with Hepatitis B and C virus-related cirrhosis

2019 ◽  
Vol 57 (4) ◽  
pp. 334-340 ◽  
Author(s):  
Răzvan Peagu ◽  
Roxana Săraru ◽  
Ana Necula ◽  
Alexandru Moldoveanu ◽  
Ana Petrişor ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Esophageal Varices ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Good Method ◽  
Acoustic Radiation Force Impulse ◽  
Upper Gastrointestinal Endoscopy ◽  
Biochemical Tests ◽  
Non Invasive ◽  
Spleen Stiffness

Abstract Introduction. Current guidelines recommend that all patients with cirrhosis undergo upper gastrointestinal endoscopy (UGE) screening for esophageal varices (EV). Unfortunately, UGE has a lot of disadvantages, consequently various non-invasive methods of diagnosing EV have been proposed. We evaluated if spleen stiffness (SS) measured by Acoustic Radiation Force Impulse (ARFI) is a viable technique in diagnosing EV. Methods. We recruited 178 patients with cirrhosis caused by Hepatitis B and C who underwent biochemical tests, abdominal ultrasound, UGE, LS and SS measurements using ARFI elastography. Based on the endoscopic results the patients were divided in 3 groups: without EV, with small EV (<5 mm) and with large EV (>5 mm). Results. ARFI SS was the only non-invasive parameter associated with the presence of EV (2.7±0.30 vs. 3.4±0.52, p<0.001) and large EV (2.91±0.36 vs. 3.86±0.37, p=0.001) after multivariate logistic regression (p<0.001). ARFI SS for predicting EV showed an AUROC of 0.872 (CI 95%: 0.799–0.944), for a cut-off value of 2.89 m/s: Sensitivity (Se) 91.4% (CI 95%: 81–97%), Specificity (Sp) 67.7% (CI 95%: 51–85%). ARFI SS for diagnosing large EV (>5mm) had better results with an AUROC 0.969 (CI 95%:0.935–0.99), and for a cut-off of 3.30 m/s: Se 96.4% (CI 95%: 82–99.9%), Sp 88.5% (CI 95%: 78–95%). Conclusions. SS measured using ARFI is a good method of detecting EV and is an excellent method of diagnosing large EV in patients with virus-related cirrhosis.

Measurement of Spleen Stiffness by Acoustic Radiation Force Impulse Imaging Identifies Cirrhotic Patients With Esophageal Varices

2013 ◽  
Vol 144 (1) ◽  
pp. 92-101.e2 ◽  
Author(s):  
Yoshitaka Takuma ◽  
Kazuhiro Nouso ◽  
Youichi Morimoto ◽  
Junko Tomokuni ◽  
Akiko Sahara ◽  
...  
Keyword(s):  
Esophageal Varices ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Acoustic Radiation Force Impulse ◽  
Spleen Stiffness ◽  
Cirrhotic Patients

scholarly journals Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Andréia Coutinho Facin ◽  
Ricardo Andres Ramirez Uscategui ◽  
Marjury Cristina Maronezi ◽  
Letícia Pavan ◽  
Mareliza Possa Menezes ◽  
...  
Keyword(s):  
Acoustic Radiation ◽  
Sleep Apnea Syndrome ◽  
Liver Stiffness ◽  
Principal Component ◽  
Radiation Force ◽  
Abdominal Ultrasound ◽  
Caudate Lobe ◽  
Acoustic Radiation Force Impulse ◽  
Clinical Biomarkers ◽  
Left And Right

Abstract The purpose of this study is to determine whether the brachycephalic obstructive airway syndrome (BOAS) is correlated to alterations in liver and spleen elasticity. Forty-eight brachycephalic and 22 mesocephalic dogs were submitted to a BOAS functional assessment, laboratory tests, abdominal ultrasound and liver and spleen Acoustic Radiation Force Impulse (ARFI) elastography. Dogs clinically affected by BOAS had higher values of liver stiffness (p < 0.001) than healthy dogs: medial lobes (1.57 ± 0.37 m/s), left and right lateral lobes (1.54 ± 0.50 m/s, 1.23 ± 0.28 m/s, respectively) and caudate lobe (1.28 ± 0.42 m/s). Compared to the mesocephalic group, the brachycephalic group (BOAS clinically affected and unaffected dogs) had higher spleen (2.51 ± 0.45 m/s; p < 0.001) and liver stiffness (p < 0.001): medial lobes (1.53 ± 0.37 m/s), left and right lateral lobes (1.47 ± 0.47 m/s, 1.20 ± 0.30 m/s, respectively) and caudate lobe (1.23 ± 0.40 m/s). Principal component analysis explained 70% of the variances composed by liver stiffness increase, erythrocytes and alanine aminotransferase reduction. Brachycephalic dogs had higher spleen and liver stiffness and a subacute inflammatory state, which represent another BOAS systemic effect. Consequently, these dogs can be at higher risk of hepatic disorders compared with mesocephalic dogs, similarly to humans affected by sleep apnea syndrome.

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