scholarly journals Retinal capillary rarefaction is associated with arterial and kidney damage in hypertension

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shaun Frost ◽  
Janis Marc Nolde ◽  
Justine Chan ◽  
Anu Joyson ◽  
Cynthia Gregory ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Pulse Wave Velocity ◽  
Glomerular Filtration ◽  
Wave Velocity ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Pulse Wave ◽  
Vascular Density ◽  
Capillary Rarefaction ◽  
Retinal Capillary

AbstractMicrovascular disease and rarefaction are key pathological hallmarks of hypertension. The retina uniquely allows direct, non-invasive investigation of the microvasculature. Recently developed optical coherence tomography angiography now allows investigation of the fine retinal capillaries, which may provide a superior marker of overall vascular damage. This was a prospective cross-sectional study to collect retinal capillary density data on 300 normal eyes from 150 hypertensive adults, and to investigate possible associations with other organ damage markers. The average age of participants was 54 years and there was a greater proportion of males (85; 57%) than females. Multivariate, confounder adjusted linear regression showed that retinal capillary rarefaction in the parafovea was associated with increased pulse wave velocity (β = − 0.4, P = 0.04), log-albumin/creatinine ratio (β = − 0.71, P = 0.003), and with reduced estimated glomerular filtration rate (β = 0.04, P = 0.02). Comparable significant associations were also found for whole-image vascular-density, for foveal vascular-density significant associations were found with pulse wave velocity and estimated glomerular filtration rate only. Our results indicate that retinal capillary rarefaction is associated with arterial stiffness and impaired kidney function. Retinal capillary rarefaction may represent a useful and simple test to assess the integrated burden of hypertension on the microvasculature irrespective of current blood pressure levels.

scholarly journals Hubungan Shear Wave Elastography Ginjal dengan Estimated Glomerular Filtration Rate pada Pasien Penyakit Ginjal Kronik

2019 ◽  
Vol 30 (4) ◽  
pp. 287
Author(s):  
Asnita Arif ◽  
Nurlaily Idris ◽  
Bachtiar Murtala ◽  
Andi Alfian Zainuddin ◽  
Sri Asriyani ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Shear Wave ◽  
Wave Velocity ◽  
Shear Wave Velocity ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Shear Wave Elastography

<p>Penyakit ginjal kronik (PGK) merupakan masalah kesehatan global dengan biaya ekonomi tinggi pada sistem kesehatan sehingga dibutuhkan modalitas pencitraan klinis non invasif untuk mendeteksi penyakit ginjal pada stadium awal. Shear wave elastography (SWE) merupakan pemeriksaan imaging untuk menilai tingkat keparahan dari perubahan morfologi kronik ginjal berdasarkan pengukuran elastisitas kortex. Penelitian ini bertujuan mengetahui hubungan antara SWE dengan estimated glomerular filtration rate (eGFR) sehingga SWE dapat direkomendasikan untuk deteksi dini tingkat keparahan penyakit ginjal kronik.  Penelitian ini dilakukan di bagian Radiologi Rumah Sakit Umum Pusat Dr. Wahidin Sudirohusodo Makassar dari bulan September 2018 sampai dengan Februari 2019. Desain penelitian yang digunakan adalah observasional dengan rancangan potong lintang. Sampel penelitian sebanyak 118 sampel yang terdiri dari 71 sampel dengan penyakit ginjal kronik dan 47 sampel normal. Pemeriksaan ultrasonografi yang dilakukan dengan metode SWE untuk mengukur shear wave velocity (SWV) pada kedua ginjal dengan tiga kali pengukuran pada kortex ginjal. Nilai median dari SWV pada kedua ginjal dihubungkan dengan eGFR. Data dianalisis dengan uji korelasi Spearman. Hasil penelitian menunjukkan bahwa nilai median SWV pada kelompok sampel normal adalah 2,02±0,32m/s pada ginjal kanan  2,01±0,32m/s pada ginjal kiri yang cenderung menurun dengan bertambahnya  usia. Terdapat korelasi positif yang signifikan antara nilai SWV pada ginjal kanan dan kiri dengan eGFR, dengan arah korelasi positif (p&lt;0,0001). Pada penelitian ini, terdapat pula korelasi negatif yang signifikan antara tekanan darah dan proteinuria dengan eGFR maupun dengan SWV pada pasien penyakit ginjal kronik.</p>

scholarly journals Longitudinal Study of Brachial-Ankle Pulse Wave Velocity and Change in Estimated Glomerular Filtration Rate among Chinese Adults

2021 ◽  
pp. 1-9
Author(s):  
Junjuan Li ◽  
Liufu Cui ◽  
Xinyuan Zhang ◽  
Jinhong Hou ◽  
Aitian Wang ◽  
...  
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Longitudinal Study ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Pulse Wave ◽  
Chinese Adults ◽  
Decrease Rate

<b><i>Background and Objectives:</i></b> Studies on the association between arterial stiffness and kidney function have generated inconsistent results. Whether arterial stiffness is linked to decline in renal function warrants further study. This study aimed to investigate the association between brachial-ankle pulse wave velocity (baPWV) and longitudinal change in estimated glomerular filtration rate (eGFR) among Chinese adults. <b><i>Methods:</i></b> In this longitudinal study, 8,264 participants in a community-based cohort had baPWV measured in 2010–2011 and were followed in subsequent surveys through to 2016. During each survey visit, fasting blood samples were collected for serum creatinine and eGFR was calculated. Participants were divided into 5 groups (Q1-Q5) by baPWV quintile. The association between baPWV and longitudinal changes in eGFR was assessed using generalized estimating equation models. <b><i>Results:</i></b> A total of 8,045 participants were included in the final analysis. The average age was 54 ± 12 years (age range 24–97 years), and mean eGFR was 93.0 ± 18.6 mL/min/1.73 m<sup>2</sup>. There was an inverse linear association between baseline baPWV and eGFR change rate (<i>p</i> &#x3c; 0.001). Compared with Q1 (lowest) group, the mean differences and 95% CI in eGFR decrease rate among Q2–Q5 groups were −0.23 (−0.62, 0.16), −0.67 (−1.06, −0.28), −1.11 (−1.50, −0.72), and −1.30 (−1.69, −0.92) mL/min/1.73 m<sup>2</sup> per year, respectively, after adjustment for age, gender, and other potential confounders (<i>p</i> trend &#x3c; 0.0001). For each 100 cm/s increase in baPWV at baseline, the fully adjusted mean difference in eGFR decrease rate was −0.14 mL/min/1.73 m<sup>2</sup> per year (95% CI −0.18, −0.10; <i>p</i> &#x3c; 0.0001). Compared with participants with baPWV &#x3c; 1,400 cm/s, the fully adjusted mean difference in eGFR decrease rate was −0.92 mL/min/1.73 m<sup>2</sup> per year (95% CI −1.18, −0.66) for those with baPWV ≥ 1,400 cm/s (<i>p</i> &#x3c; 0.0001). <b><i>Conclusions:</i></b> Participants with a higher baPWV at baseline had a greater decrease in eGFR over time. Future studies could examine the relationship between baPWV and decline in renal function in higher risk cohorts, and its potential role in targeting reno-protective interventions to those who may benefit from them most.

Sign in / Sign up

Export Citation Format

Share Document