scholarly journals Hubungan Shear Wave Elastography Ginjal dengan Estimated Glomerular Filtration Rate pada Pasien Penyakit Ginjal Kronik

2019 ◽  
Vol 30 (4) ◽  
pp. 287
Author(s):  
Asnita Arif ◽  
Nurlaily Idris ◽  
Bachtiar Murtala ◽  
Andi Alfian Zainuddin ◽  
Sri Asriyani ◽  
...  

<p>Penyakit ginjal kronik (PGK) merupakan masalah kesehatan global dengan biaya ekonomi tinggi pada sistem kesehatan sehingga dibutuhkan modalitas pencitraan klinis non invasif untuk mendeteksi penyakit ginjal pada stadium awal. Shear wave elastography (SWE) merupakan pemeriksaan imaging untuk menilai tingkat keparahan dari perubahan morfologi kronik ginjal berdasarkan pengukuran elastisitas kortex. Penelitian ini bertujuan mengetahui hubungan antara SWE dengan estimated glomerular filtration rate (eGFR) sehingga SWE dapat direkomendasikan untuk deteksi dini tingkat keparahan penyakit ginjal kronik.  Penelitian ini dilakukan di bagian Radiologi Rumah Sakit Umum Pusat Dr. Wahidin Sudirohusodo Makassar dari bulan September 2018 sampai dengan Februari 2019. Desain penelitian yang digunakan adalah observasional dengan rancangan potong lintang. Sampel penelitian sebanyak 118 sampel yang terdiri dari 71 sampel dengan penyakit ginjal kronik dan 47 sampel normal. Pemeriksaan ultrasonografi yang dilakukan dengan metode SWE untuk mengukur shear wave velocity (SWV) pada kedua ginjal dengan tiga kali pengukuran pada kortex ginjal. Nilai median dari SWV pada kedua ginjal dihubungkan dengan eGFR. Data dianalisis dengan uji korelasi Spearman. Hasil penelitian menunjukkan bahwa nilai median SWV pada kelompok sampel normal adalah 2,02±0,32m/s pada ginjal kanan  2,01±0,32m/s pada ginjal kiri yang cenderung menurun dengan bertambahnya  usia. Terdapat korelasi positif yang signifikan antara nilai SWV pada ginjal kanan dan kiri dengan eGFR, dengan arah korelasi positif (p&lt;0,0001). Pada penelitian ini, terdapat pula korelasi negatif yang signifikan antara tekanan darah dan proteinuria dengan eGFR maupun dengan SWV pada pasien penyakit ginjal kronik.</p>

Diagnostics ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 18
Author(s):  
Chi Qin ◽  
Hailong Jin ◽  
Haixiang Zhang ◽  
Yun Zhang ◽  
Zhaojie Guan ◽  
...  

The purpose of this study was to evaluate the feasibility of the combination of point-shear wave elastography (p-SWE) and estimated glomerular filtration rate (eGFR) for assessing different stages of interstitial fibrosis and tubular atrophy (IF/TA) in patients with chronic renal allograft dysfunction (CAD). From September 2020 to August 2021, 47 patients who underwent renal biopsy and p-SWE examinations were consecutively enrolled in this study. The areas under the receiver operating characteristic curves (AUCs) were calculated to evaluate overall accuracy and to identify the optimal cutoff values for different IF/TA stages. A total of 43 patients were enrolled in this study. The renal cortical stiffness and eGFR showed a significant difference between IF/TA Grade 0–1 and Grade 2–3 (p < 0.001). Additionally, renal stiffness and eGFR were independent predictors for moderate-to-severe IF/TA (Grade ≥ 2) according to multiple logistic regression analysis. The combination of p-SWE and eGFR, with an optimal cutoff value of −1.63, was superior to eGFR alone in assessing moderate-to-severe interstitial fibrosis (AUC, 0.86 vs. 0.72, p = 0.02) or tubular atrophy (AUC, 0.88 vs. 0.74, p = 0.02). There was no difference between p-SWE and eGFR in assessing moderate-to-severe IF/TA (AUC, 0.85 vs. 0.79, p = 0.61). Therefore, combining p-SWE and eGFR is worthy of clinical popularization and application.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shaun Frost ◽  
Janis Marc Nolde ◽  
Justine Chan ◽  
Anu Joyson ◽  
Cynthia Gregory ◽  
...  

AbstractMicrovascular disease and rarefaction are key pathological hallmarks of hypertension. The retina uniquely allows direct, non-invasive investigation of the microvasculature. Recently developed optical coherence tomography angiography now allows investigation of the fine retinal capillaries, which may provide a superior marker of overall vascular damage. This was a prospective cross-sectional study to collect retinal capillary density data on 300 normal eyes from 150 hypertensive adults, and to investigate possible associations with other organ damage markers. The average age of participants was 54 years and there was a greater proportion of males (85; 57%) than females. Multivariate, confounder adjusted linear regression showed that retinal capillary rarefaction in the parafovea was associated with increased pulse wave velocity (β = − 0.4, P = 0.04), log-albumin/creatinine ratio (β = − 0.71, P = 0.003), and with reduced estimated glomerular filtration rate (β = 0.04, P = 0.02). Comparable significant associations were also found for whole-image vascular-density, for foveal vascular-density significant associations were found with pulse wave velocity and estimated glomerular filtration rate only. Our results indicate that retinal capillary rarefaction is associated with arterial stiffness and impaired kidney function. Retinal capillary rarefaction may represent a useful and simple test to assess the integrated burden of hypertension on the microvasculature irrespective of current blood pressure levels.


Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1557-P
Author(s):  
KRISTINA BOYE ◽  
REEMA MODY ◽  
JIANMIN WU ◽  
MAUREEN J. LAGE ◽  
FADY T. BOTROS ◽  
...  

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1695-P
Author(s):  
STUART MCGURNAGHAN ◽  
ATHINA SPILIOPOULOU ◽  
HELEN M. COLHOUN ◽  
PAUL M. MCKEIGUE

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