scholarly journals A novel prognostic model to predict outcome of artificial liver support system treatment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jin Shang ◽  
Mengqiao Wang ◽  
Qin Wen ◽  
Yuanji Ma ◽  
Fang Chen ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Decision Tree ◽  
Support System ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Liver Support System ◽  
Artificial Liver Support System ◽  
Prognosis Group ◽  
First Time

AbstractThe prognosis of Artificial liver support system (ALSS) for hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is hard to be expected, which results in multiple operations of ALSS and excessive consumption of plasma, increase in clinical cost. A total of 375 HBV-ACLF patients receiving ALSS treatment were randomly divided a train set and an independent test set. Logistic regression analysis was conducted and a decision tree was built based on 3-month survival as outcome. The ratio of total bilirubin before and after the first time of ALSS treatment was the most significant prognostic factor, we named it RPTB. Further, a decision tree based on the multivariate logistic regression model using CTP score and the RPTB was built, dividing patients into 3 main groups such as favorable prognosis group, moderate prognosis group and poor prognosis group. A clearly-presented and easily-understood decision tree was built with a good predictive value of prognosis in HBV-related ACLF patients after first-time ALSS treatment. It will help maximal the therapeutic value of ALSS treatment and may play an important role in organ allocation for liver transplantation in the future.

scholarly journals Characterization of an Artificial Liver Support System-Related Vasovagal Reaction

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Shanshan Ma ◽  
Zhongyang Xie ◽  
Huafen Zhang ◽  
Jiangcheng Rong ◽  
Lingjian Zhang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Support System ◽  
Artificial Liver ◽  
Severe Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Vasovagal Reaction ◽  
Liver Support System ◽  
Artificial Liver Support System ◽  
Associated Symptoms

Objective. An artificial liver support system (ALSS) is an effective therapy for patients with severe liver injury. A vasovagal reaction (VVR) is a common complication in various treatment settings but has not been reported previously in ALSS. Methods. This study retrospectively evaluated patients who suffered an ALSS-related VRR between January 2018 and June 2019. We collected data from VVR episodes including onset time, duration, changes in heart rate (HR) and blood pressure (BP), and drug treatment. Results. Among 637 patients who underwent ALSS treatment, 18 were included in the study. The incidence of VVR was approximately 2.82%. These patients were characterized by a rapid decrease in BP or HR with associated symptoms such as chest distress, nausea, and vomiting. The majority of patients (78%) suffered a VVR during their first ALSS treatment. Sixteen patients (89%) had associated symptoms after treatment began. Sixteen patients (89%) received human albumin or Ringer’s solution. Atropine was used in 11 patients (61%). The symptoms were relieved within 20 min in 15 patients and over 20 min in 3 patients. Conclusions. A VVR is a rare complication in patients with severe liver injury undergoing ALSS treatment. Low BP and HR are the main characteristics of a VVR.

scholarly journals Efficacy of a Larger Version of the Hybrid Artificial Liver Support System Using a Polyurethane Foam/Spheroid Packed-Bed Module in a Warm Ischemic Liver Failure Pig Model for Preclinical Experiments

2003 ◽  
Vol 12 (2) ◽  
pp. 101-107 ◽  
Author(s):  
Yo-Ichi Yamashita ◽  
Mitsuo Shimada ◽  
Eiji Tsujita ◽  
Ken Shirabe ◽  
Hiroyuki Ijima ◽  
...  
Keyword(s):  
Liver Failure ◽  
Polyurethane Foam ◽  
Support System ◽  
Packed Bed ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Liver Support System ◽  
Artificial Liver Support System ◽  
Group Serum

We have reported the usefulness of a polyurethane foam packed-bed culture system of hepatocyte spheroids as a hybrid artificial liver support system (PUF-HALSS). The aim of this study was to evaluate in detail the efficacy in serum parameters regarding the liver function of a larger version of the PUF-HALSS containing 2 × 1010 porcine hepatocytes for clinical use in warm ischemic liver failure pigs. Warm ischemic liver failure pigs weighing 25 kg were divided into two groups: (1) a control group (n = 3), in which each pig was attached to a PUF-HALSS without hepatocytes, and (2) a HALSS group (n = 3), in which each pig was attached to a PUF-HALSS. In the HALSS group, the increase of blood ammonia was completely suppressed and blood lactate levels were significantly suppressed. The Fisher's ratio was better maintained, and the increase of total bile acid, glycochenodeoxycholic acid, and taurochenodeoxycholic acid was significantly suppressed in the HALSS group. Serum creatinine levels were significantly lower, and blood glucose levels were significantly higher in the HALSS group. Serum levels of tumor necrosis factor- a were not elevated in either group. In conclusion, the larger version of the PUF-HALSS demonstrated many advantages as a liver support system in warm ischemic liver failure pigs.

Artificial Liver Support System in China: A Review Over the Last 30 Years

2006 ◽  
Vol 10 (2) ◽  
pp. 160-167 ◽  
Author(s):  
Lan Juan Li ◽  
Yi Min Zhang ◽  
Xiao Li Liu ◽  
Wei Bo Du ◽  
Jian Rong Huang ◽  
...  
Keyword(s):  
Support System ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Liver Support System ◽  
Artificial Liver Support System
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