scholarly journals On the flexible needle insertion into the human liver

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Veturia Chiroiu ◽  
Nicoleta Nedelcu ◽  
Doina Pisla ◽  
Ligia Munteanu ◽  
Cristian Rugină
Keyword(s):  
Elastic Properties ◽  
Couple Stress ◽  
Human Liver ◽  
Liver Tumors ◽  
Unit Area ◽  
Needle Insertion ◽  
Micropolar Elasticity ◽  
Robotic Assisted ◽  
Local Rotation

AbstractIn the present research, the navigation of a flexible needle into the human liver in the context of the robotic-assisted intraoperative treatment of the liver tumors, is reported. Cosserat (micropolar) elasticity is applied to describe the interaction between the needle and the human liver. The theory incorporates the local rotation of points and the couple stress (a torque per unit area) as well as the force stress (force per unit area) representing the chiral features of the human liver. To predict the deformation of the needle and the liver, the elastic properties of the human liver have been evaluated. Outcomes reveal that considering smaller deformations of the needle and the liver results in better needle navigation mechanism. The needle geometry can enhance the penetration.

scholarly journals Modeling of the Flexible Needle Insertion into the Human Liver

2021 ◽  
Author(s):  
Veturia Chiroiu ◽  
Ligia Munteanu ◽  
Cristian Rugină ◽  
Nicoleta Nedelcu
Keyword(s):  
Elasticity Theory ◽  
Molecular Diagnosis ◽  
Human Liver ◽  
Chemotherapeutic Agent ◽  
Liver Tumors ◽  
Needle Insertion ◽  
Micropolar Elasticity ◽  
Robotic Assisted ◽  
Tumor Modeling

The insertion of the needle is difficult because the deformation and displacement of the organs are the key elements in the surgical act. Liver and tumor modeling are essential in the development of the needle insertion model. The role of the needle is to deliver into the tumor an active chemotherapeutic agent. We describe in this chapter the deformation of the needle during its insertion into the human liver in the context of surgery simulation of the high- robotic-assisted intraoperative treatment of liver tumors based on the integrated imaging-molecular diagnosis. The needle is a bee barbed type modeled as a flexible thread within the framework of the Cosserat (micropolar) elasticity theory.

Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression

2005 ◽  
Vol 24 (1) ◽  
pp. 73-75 ◽  
Author(s):  
Siew Hong Lam ◽  
Yi Lian Wu ◽  
Vinsensius B Vega ◽  
Lance D Miller ◽  
Jan Spitsbergen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tumor Progression ◽  
Human Liver ◽  
Liver Tumors ◽  
Gene Expression Signatures

scholarly journals Human liver tumors in relation to steroidal usage.

1983 ◽  
Vol 50 ◽  
pp. 201-208 ◽  
Author(s):  
G H Barrows ◽  
W M Christopherson
Keyword(s):  
Human Liver ◽  
Liver Tumors

scholarly journals The Epidemiology of Human Liver Tumors

1982 ◽  
Vol 10 (2) ◽  
pp. 121-125 ◽  
Author(s):  
John Higginson
Keyword(s):  
Human Liver ◽  
Liver Tumors

scholarly journals Predicting Clinical Efficacy of Vascular Disrupting Agents in Rodent Models of Primary and Secondary Liver Cancers: An Overview with Imaging-Histopathology Correlation

Diagnostics ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 78 ◽  
Author(s):  
Yewei Liu ◽  
Shuncong Wang ◽  
Xiaohui Zhao ◽  
Yuanbo Feng ◽  
Guy Bormans ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Liver Cancer ◽  
Human Liver ◽  
Cellular Differentiation ◽  
Liver Tumors ◽  
Pancreatic Tumors ◽  
Imaging Biomarkers ◽  
Vascular Disrupting Agents ◽  
Liver Cancers ◽  
Vascular Disrupting

Vascular disrupting agents (VDAs) have entered clinical trials for over 15 years. As the leading VDA, combretastatin A4 phosphate (CA4P) has been evaluated in combination with chemotherapy and molecular targeting agents among patients with ovarian cancer, lung cancer and thyroid cancer, but still remains rarely explored in human liver cancers. To overcome tumor residues and regrowth after CA4P monotherapy, a novel dual targeting pan-anticancer theragnostic strategy, i.e., OncoCiDia, has been developed and shown promise previously in secondary liver tumor models. Animal model of primary liver cancer is time consuming to induce, but of value for more closely mimicking human liver cancers in terms of tumor angiogenesis, histopathological heterogeneity, cellular differentiation, tumor components, cancer progression and therapeutic response. Being increasingly adopted in VDA researches, multiparametric magnetic resonance imaging (MRI) provides imaging biomarkers to reflect in vivo tumor responses to drugs. In this article as a chapter of a doctoral thesis, we overview the construction and clinical relevance of primary and secondary liver cancer models in rodents. Target selection for CA4P therapy assisted by enhanced MRI using hepatobiliary contrast agents (CAs), and therapeutic efficacy evaluated by using MRI with a non-specific contrast agent, dynamic contrast enhanced (DCE) imaging, diffusion weighted imaging (DWI) are also described. We then summarize diverse responses among primary hepatocellular carcinomas (HCCs), secondary liver and pancreatic tumors to CA4P, which appeared to be related to tumor size, vascularity, and cellular differentiation. In general, imaging-histopathology correlation studies allow to conclude that CA4P tends to be more effective in secondary liver tumors and in more differentiated HCCs, but less effective in less differentiated HCCs and implanted pancreatic tumor. Notably, cirrhotic liver may be responsive to CA4P as well. All these could be instructive for future clinical trials of VDAs.

Micropolar elasticity theory: a survey of linear isotropic equations, representative notations, and experimental investigations

2016 ◽  
Vol 22 (2) ◽  
pp. 224-242 ◽  
Author(s):  
Soroosh Hassanpour ◽  
Glenn R. Heppler
Keyword(s):  
Elasticity Theory ◽  
Elastic Constants ◽  
Couple Stress ◽  
Elastic Moduli ◽  
Experimental Results ◽  
Experimental Investigations ◽  
Micropolar Elasticity ◽  
Classical Elasticity ◽  
Material Constants ◽  
Isotropic Theory

This paper is devoted to a review of the linear isotropic theory of micropolar elasticity and its development with a focus on the notation used to represent the micropolar elastic moduli and the experimental efforts taken to measure them. Notation, not only the selected symbols but also the approaches used for denoting the material elastic constants involved in the model, can play an important role in the micropolar elasticity theory especially in the context of investigating its relationship with the couple-stress and classical elasticity theories. Two categories of notation, one with coupled classical and micropolar elastic moduli and one with decoupled classical and micropolar elastic moduli, are examined and the consequences of each are addressed. The misleading nature of the former category is also discussed. Experimental investigations on the micropolar elasticity and material constants are also reviewed where one can note the questionable nature and limitations of the experimental results reported on the micropolar elasticity theory.

scholarly journals Decellularised Human Liver is too Heterogeneous for Designing a Generic ECM-mimic Hepatic Scaffold

2016 ◽  
Author(s):  
Giorgio Mattei ◽  
Chiara Magliaro ◽  
Andrea Pirone ◽  
Arti Ahluwalia
Keyword(s):  
Human Liver ◽  
Unit Area ◽  
Biochemical Properties ◽  
Matrix Composition ◽  
Hepatic Tissue ◽  
Short Supply ◽  
3 Dimensional ◽  
Ecm Extracellular Matrix ◽  
Donor Variability ◽  
Human Livers

AbstractDecellularised human livers are considered the perfect ECM (extracellular matrix) surrogate because both 3-dimensional architecture and biological features of the hepatic microenvironment are thought to be preserved. However, donor human livers are in chronically short supply, both for transplantation or as decellularised scaffolds, and will become even scarcer as life expectancy increases. It is hence of interest to determine the structural and biochemical properties of human hepatic ECM to derive design criteria for engineering bio-mimetic scaffolds. The intention of this work was to obtain quantitative design specifications for fabricating scaffolds for hepatic tissue engineering using human livers as a template. To this end, hepatic samples from 5 human donors were decellularised using a protocol shown to reproducibly conserve matrix composition and micro-structure in porcine livers. The decellularisation outcome was evaluated through histological and quantitative image analyses to evaluate cell removal, protein and glycosaminoglycan content per unit area. Applying the same decellularisation protocol to human liver samples obtained from 5 different donors yielded 5 different outcomes. Only 1 liver out of 5 was completely decellularised, while the other 4 showed different levels of remaining cells. Moreover, protein and glycosaminoglycan content per unit area after decellularisation were also found to be donor-dependent. The donor-to-donor variability of human livers thus precludes their use as templates for engineering a generic 'one-size fits all' ECM-mimic hepatic scaffold.

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