Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure

AbstractWe investigated the time and location of retinal perfusion recovery after surgical intraocular pressure (IOP) lowering in glaucoma by using optical coherent tomography angiography (OCTA). Seventeen patients were analyzed. The 4.5 × 4.5-mm OCTA scans centered on the disc were performed preoperatively and postoperatively at 6 weeks, 3 months, and 6 months. The peripapillary retinal nerve fiber layer (NFL) thickness, NFL plexus capillary density (NFLP-CD) and visual field (VF) were measured overall and in 8 corresponding sectors. The low-perfusion area (LPA) was used to assess the cumulative area where local NFLP-CD was significantly below normal. At 6 months, the average IOP decreased 5.3 mmHg (P = 0.004), LPA decreased by 15% (P = 0.005), and NFLP-CD improved by 12% (P < 0.001). The NFL thickness and VF mean deviation didn’t change significantly at any time point. Among the sectors with significant preoperative NFLP-CD loss, the recovery at 6 months was greatest in sectors with minimal preoperative NFL thinning (P < 0.001). In conclusion, surgical IOP lowering may improve NFLP capillary perfusion after 6 months. The perfusion recovery tended to occur in areas with minimal NFL thinning at baseline. OCTA parameters may have potential usefulness as pharmacodynamic biomarkers for glaucoma therapy.

Download Full-text

Estimating Visual Field Mean Deviation using Optical Coherence Tomographic Nerve Fiber Layer Measurements in Glaucoma Patients

Scientific Reports ◽

10.1038/s41598-019-54792-w ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 1

Author(s):

Ou Tan ◽

David S. Greenfield ◽

Brian A. Francis ◽

Rohit Varma ◽

Joel S. Schuman ◽

...

Keyword(s):

Visual Field ◽

Nerve Fiber ◽

Weighted Averaging ◽

Mean Deviation ◽

Optical Coherence ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Maximal Correlation ◽

Advanced Stages ◽

Higher Sensitivity

AbstractTo construct an optical coherence tomography (OCT) nerve fiber layer (NFL) parameter that has maximal correlation and agreement with visual field (VF) mean deviation (MD). The NFL_MD parameter in dB scale was calculated from the peripapillary NFL thickness profile nonlinear transformation and VF area-weighted averaging. From the Advanced Imaging for Glaucoma study, 245 normal, 420 pre-perimetric glaucoma (PPG), and 289 perimetric glaucoma (PG) eyes were selected. NFL_MD had significantly higher correlation (Pearson R: 0.68 vs 0.55, p < 0.001) with VF_MD than the overall NFL thickness. NFL_MD also had significantly higher sensitivity in detecting PPG (0.14 vs 0.08) and PG (0.60 vs 0.43) at the 99% specificity level. NFL_MD had better reproducibility than VF_MD (0.35 vs 0.69 dB, p < 0.001). The differences between NFL_MD and VF_MD were −0.34 ± 1.71 dB, −0.01 ± 2.08 dB and 3.54 ± 3.18 dB and 7.17 ± 2.68 dB for PPG, early PG, moderate PG, and severe PG subgroups, respectively. In summary, OCT-based NFL_MD has better correlation with VF_MD and greater diagnostic sensitivity than the average NFL thickness. It has better reproducibility than VF_MD, which may be advantageous in detecting progression. It agrees well with VF_MD in early glaucoma but underestimates damage in moderate~advanced stages.

Download Full-text

Intraocular pressure, optic nerve fiber layer thickness and visual field in normotensive eyes with narrow drainage angle

10.5353/th_b4501110 ◽

2006 ◽

Author(s):

Yee-hang, Thomas Chiu

Keyword(s):

Intraocular Pressure ◽

Optic Nerve ◽

Visual Field ◽

Nerve Fiber ◽

Layer Thickness ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Optic Nerve Fiber ◽

Nerve Fiber Layer Thickness

Download Full-text

Sectorwise Visual Field Simulation Using Optical Coherence Tomographic Angiography Nerve Fiber Layer Plexus Measurements in Glaucoma

American Journal of Ophthalmology ◽

10.1016/j.ajo.2019.11.018 ◽

2020 ◽

Vol 212 ◽

pp. 57-68

Author(s):

Liang Liu ◽

Ou Tan ◽

Eliesa Ing ◽

John C. Morrison ◽

Beth Edmunds ◽

...

Keyword(s):

Visual Field ◽

Nerve Fiber ◽

Optical Coherence ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Field Simulation ◽

Tomographic Angiography

Download Full-text

Longitudinal analysis of optic nerve edema, retinal nerve fiber layer thickness, and visual field mean deviation in pediatric patients with intracranial hypertension

Journal of American Association for Pediatric Ophthalmology and Strabismus ◽

10.1016/j.jaapos.2019.08.218 ◽

2019 ◽

Vol 23 (4) ◽

pp. e59-e60

Author(s):

Hersh Varma ◽

Hilliary E. Inger ◽

Anastasia Alex ◽

Catherine O. Jordan ◽

Shawn C. Aylward ◽

...

Keyword(s):

Optic Nerve ◽

Visual Field ◽

Intracranial Hypertension ◽

Nerve Fiber ◽

Layer Thickness ◽

Longitudinal Analysis ◽

Pediatric Patients ◽

Mean Deviation ◽

Fiber Layer ◽

Nerve Fiber Layer Thickness

Download Full-text

Effects of fasting on peripapillary capillary density, peripapillary nerve fiber layer, intraocular pressure and central corneal thickness

International Ophthalmology ◽

10.1007/s10792-020-01310-x ◽

2020 ◽

Vol 40 (6) ◽

pp. 1439-1447 ◽

Cited By ~ 1

Author(s):

Naveed Nilforushan ◽

Navid Abolfathzadeh ◽

Mohammad Banifatemi ◽

Arezoo Miraftabi ◽

Mahsa Sardarinia ◽

...

Keyword(s):

Intraocular Pressure ◽

Nerve Fiber ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Capillary Density ◽

Fiber Layer ◽

Nerve Fiber Layer

Download Full-text

Changes in peripapillary retinal nerve fiber layer thickness in chronic glaucoma and non-glaucoma patients after phacoemulsification cataract surgery

Medical Journal of Indonesia ◽

10.13181/mji.v24i4.1181 ◽

2015 ◽

Vol 24 (4) ◽

pp. 221-7

Author(s):

Olivia P. Perdana ◽

Andi A. Victor ◽

Virna D. Oktarina ◽

Joedo Prihartono

Keyword(s):

Visual Field ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

T Test ◽

Mean Deviation ◽

Fiber Layer ◽

Chronic Glaucoma ◽

Nerve Fiber Layer ◽

Rnfl Thickness ◽

Glaucoma Group

Background: Phacoemulsification is a common cataract operation nowadays. During phacoemulsification, variation in intraocular pressure (IOP) may occur, which might change the retinal nerve fiber layer (RNFL) thickness. This study was aimed to evaluate the change in peripapillary RNFL thickness and mean deviation (MD) of visual field after phacoemulsification in chronic primary glaucoma and non-glaucoma patients. Methods: Cohort prospective study was done on 26 patients (13 chronic glaucoma eyes and 13 non-glaucoma eyes) who underwent phacoemulsification. The changes in peripapillary RNFL thickness and MD of visual field were measured as the primary outcome. Comparison between pre- and post-surgery was analyzed with paired t-test, while unpaired t-test was used for comparison between groups.Results: There were no significant changes in RNFL thickness on both groups. Average RNFL thickness in glaucoma group before and after phacoemulsification were 94.9±20.0 μm and 99.1±21.3 μm, respectively (p>0.05). Average RNFL thickness in non-glaucoma group were 100.2±11.1 μm and 101.7±6.8 μm, respectively (p>0.05). Glaucoma patients yielded decreasing mean deviation (MD) of visual field, but it was not statistically significant (p=0.071). In contrast, the MD of visual field after surgery was significantly increased in non-glaucoma group (p=0.005).Conclusion: Phacoemulsification tended to increase peripapillary RNFL thickness in glaucoma or non-glaucoma patients. The visual field tended to decrease in glaucoma patients, but was significantly increased in non-glaucoma patients.

Download Full-text

Evaluation of the Retinal Nerve Fiber Layer Thickness, the Mean Deviation, and the Visual Field Index in Progressive Glaucoma

Journal of Glaucoma ◽

10.1097/ijg.0000000000000280 ◽

2016 ◽

Vol 25 (3) ◽

pp. e229-e235 ◽

Cited By ~ 9

Author(s):

Sebastián A. Banegas ◽

Alfonso Antón ◽

Antonio Morilla ◽

Marco Bogado ◽

Eleonora M. Ayala ◽

...

Keyword(s):

Visual Field ◽

Nerve Fiber ◽

Layer Thickness ◽

Retinal Nerve Fiber Layer ◽

Mean Deviation ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Visual Field Index ◽

Nerve Fiber Layer Thickness ◽

The Mean

Download Full-text

The effect of mirtogenol towards the changes in retinal nerve fiber layer thickness and visual field in primary open angle glaucoma

Ophthalmologica Indonesiana ◽

10.35749/journal.v43i1.134 ◽

2019 ◽

Vol 43 (1) ◽

pp. 28

Author(s):

Astriviani Widyakusuma ◽

Widya Artini ◽

Virna Dwi Oktariana ◽

Joedo Prihartono

Keyword(s):

Visual Field ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Open Angle Glaucoma ◽

Visual Fields ◽

Mean Deviation ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Rnfl Thickness ◽

Retinal Nerve Fiber

Objective: To evaluate the effect of Mirtogenol towards the changes in retinal nerve fiber layer (RNFL) thickness and visual field in patients with primary open angle glaucoma (POAG) with controlled IOP. Methods: This is a prospective, double blind, randomized study. Forty one POAG patients with IOP ≤ 18 mmHg were randomly assigned to receive either Mirtogenol or placebo. Changes in RNFL thickness and mean deviation of visual fields were evaluated before the treatment, as well as 4 weeks and 8 weeks after the treatment. Patients were asked for any side effects during the treatment period. Result: The average RNFL thickness in the Mirtogenol group decreased -0.70±1.63 μm from 87.29±19.39 μm before the treatment to 86.58±19.43 μm after 8 weeks of treatment, however the change was not significant (p=0.121). The average RNFL thickness in the placebo group decreased -1.74±1.79 μm from 97.14±17.19 μm before the treatment to 95.40±18.56 μm after 8 weeks of treatment, the change was statistically significant (p< 0.001). The average MD of visual field in the Mirtogenol group increased 0.542±1.93 dB after 8 weeks of treatment while the MD of visual field in the placebo group decreased -0.083±1.36 dB after 8 weeks of treatment. Hoewever the changes in MD of visual field was not significant (p>0.05). No side effect was found throughout the study. Conclusion: Mirtogenol seemed to maintain retinal nerve fiber layer thickness and increased mean deviation of visual fields.

Download Full-text