scholarly journals Evaluating posterior vitreous detachment by widefield 23-mm swept-source optical coherence tomography imaging in healthy subjects

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yoshiaki Chiku ◽  
Takao Hirano ◽  
Yoshiaki Takahashi ◽  
Ayako Tuchiya ◽  
Marie Nakamura ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Healthy Subjects ◽  
Posterior Vitreous Detachment ◽  
Internal Limiting Membrane ◽  
Optical Coherence ◽  
Swept Source ◽  
Vitreous Detachment ◽  
Swept Source Oct ◽  
B Scan Images ◽  
Sd Oct

AbstractPosterior vitreous detachment (PVD) is a separation between the posterior vitreous cortex and internal limiting membrane. Although PVD was historically considered an acute event, recent studies using spectral-domain optical coherence tomography (SD-OCT) revealed a gradual progression of PVD in healthy subjects. Although SD-OCT improved PVD studies, the narrow imaging angle and long examination time were problematic to allow wide angle capture. The Xephilio OCT-S1 (Canon), a swept-source OCT (SS-OCT) device, can obtain up to 23-mm of widefield B-scan images in a single acquisition. We used this widefield SS-OCT to quantitatively evaluate the PVD stage in 214 healthy subjects aged 4–89 years and determine whether PVD stages differ between the bilateral eyes of each patient. Age was significantly positively correlated with the overall PVD stage (ρ = 0.7520, P < 0.001). Interestingly, partial PVD occurred in children as young as 5 years, indicating that initial PVD onset may occur much earlier than previously reported. Furthermore, PVD stages of the bilateral eyes were highly consistent in 183 subjects (85.5%). Widefield 23-mm SS-OCT thus revealed that PVD started earlier than anticipated, and age was correlated with the symmetry of PVD stage. Widefield 23-mm SS-OCT may also be clinically useful for the evaluation of diseased eyes.

scholarly journals Evaluating Posterior Vitreous Detachment By Widefield 23-mm Swept-Source Optical Coherence Tomography Imaging In Healthy Subjects

2021 ◽  
Author(s):  
Yoshiaki Chiku ◽  
Takao Hirano ◽  
Yoshiaki Takahashi ◽  
Ayako Tuchiya ◽  
Marie Nakamura ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Healthy Subjects ◽  
Posterior Vitreous Detachment ◽  
Internal Limiting Membrane ◽  
Optical Coherence ◽  
Swept Source ◽  
Vitreous Detachment ◽  
Swept Source Oct ◽  
B Scan Images ◽  
Sd Oct

Abstract Posterior vitreous detachment (PVD) is a separation between the posterior vitreous cortex and internal limiting membrane. Although PVD was historically considered an acute event, recent studies using spectral-domain optical coherence tomography (SD-OCT) revealed a gradual progression of PVD in healthy subjects. Although SD-OCT improved PVD studies, the narrow imaging angle and long examination time were problematic to allow wide angle capture. The Xephilio OCT-S1 (Canon), a swept source OCT (SS-OCT) device, can obtain up to 23-mm of widefield B-scan images in a single acquisition. We used this widefield SS-OCT to quantitatively evaluate the PVD stage in 214 healthy subjects aged 4–89 years and determine whether PVD stages differ between the bilateral eyes of each patient. Age was significantly positively correlated with overall PVD stage (ρ=0.7520, P<0.001). Interestingly, partial PVD occurred in children as young as 5 years old, indicating that initial PVD onset may occur much earlier than previously reported.Furthermore, PVD stages of the bilateral eyes were highly consistent in 183 subjects (85.5%). Widefield 23-mm SS-OCT thus revealed that PVD started earlier than anticipated, and age is correlated with the symmetry of PVD stage. Widefield 23-mm SS-OCT may also be clinically useful for the evaluation of diseased eyes.

scholarly journals Angiography with optical coherence tomography as a biomarker in multiple sclerosis

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243236
Author(s):  
Beatriz Cordon ◽  
Elisa Vilades ◽  
Elvira Orduna ◽  
María Satue ◽  
Javier Perez-Velilla ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optical Coherence Tomography ◽  
Healthy Subjects ◽  
Optical Coherence ◽  
Swept Source ◽  
Retinal Microvasculature ◽  
Potential Biomarker ◽  
Relapsing Remitting ◽  
Swept Source Oct ◽  
Retinal Vascularization

Purpose To investigate superficial retinal microvascular plexuses detected by optical coherence tomography angiography (OCT-A) in multiple sclerosis (MS) subjects and compare them with healthy controls. Methods A total of 92 eyes from 92 patients with relapsing-remitting MS and 149 control eyes were included in this prospective observational study. OCT-A imaging was performed using Triton Swept-Source OCT (Topcon Corporation, Japan). The vessel density (VD) percentage in the superficial retinal plexus and optic disc area (6 x 6 mm grid) was measured and compared between groups. Results MS patients showed a significant decrease VD in the superior (p = 0.005), nasal (p = 0.029) and inferior (p = 0.040) parafoveal retina compared with healthy subjects. Patients with disease durations of more than 5 years presented lower VD in the superior (p = 0.002), nasal (p = 0.017) and inferior (p = 0.022) parafoveal areas compared with healthy subjects. Patients with past optic neuritis episodes did not show retinal microvasculature alterations, but patients with an EDSS score of less than 3 showed a significant decrease in nasal (p = 0.024) and superior (p = 0.006) perifoveal VD when compared with healthy subjects. Conclusions MS produces a decrease in retinal vascularization density in the superficial plexus of the parafoveal retina. Alterations in retinal vascularization observed in MS patients are independent of the presence of optic nerve inflammation. OCT-A has the ability to detect subclinical vascular changes and is a potential biomarker for diagnosing the presence and progression of MS.

scholarly journals Swept Source Optical Coherence Tomography Compared to Ultrasound and Biomicroscopy for Diagnosis of Posterior Vitreous Detachment

2021 ◽  
Vol Volume 15 ◽  
pp. 507-512
Author(s):  
Marlene D Wang ◽  
Cecile Truong ◽  
Zaid Mammo ◽  
Syed Amal Hussnain ◽  
Royce WS Chen
Keyword(s):  
Optical Coherence Tomography ◽  
Posterior Vitreous Detachment ◽  
Optical Coherence ◽  
Swept Source ◽  
Vitreous Detachment

Intra- and Interdevice Deviation of Optical Coherence Tomography Angiography

2019 ◽  
Vol 236 (04) ◽  
pp. 551-554 ◽  
Author(s):  
Stefan Trachsler ◽  
Arthur Baston ◽  
Marcel Menke
Keyword(s):  
Optical Coherence Tomography ◽  
Healthy Subjects ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Swept Source ◽  
Significant Difference ◽  
Capillary Plexus ◽  
Swept Source Oct ◽  
Scan Modes

Abstract Purpose To compare 4 optical coherence tomography-angiography (OCT-A) devices for foveal avascular zone (FAZ) measurements in healthy subjects. Methods The central retinas of 24 eyes of 12 healthy subjects were scanned with 4 different OCT-A devices (Optovue RTVue-XR, Zeiss Cirrus 5000-HD-OCT, a prototype Spectralis OCT2, Heidelberg Engineering, and Topcon DRI-OCT Triton Swept-source OCT). For the Topcon, Zeiss, and Optovue devices, 3-mm and 6-mm scans were performed. The Heidelberg device only provided 4-mm scans. En-face OCT-A images of the superficial and deep capillary plexus of the macular area were generated. The FAZ areas were measured and compared. Results Twenty-four healthy eyes were included. OCT-A devices showed significant differences in FAZ measurements. The Zeiss OCT-A device measured the smallest values for foveal avascular area (mean 218.7 mm2), followed by the Optovue device (229.6 mm2), the Topcon device (239.3 mm2), and the Heidelberg device (250.4 mm2). Differences were statistically significant for following devices: Heidelberg versus Optovue (p < 0.001), Heidelberg versus Zeiss (p < 0.001), Topcon versus Zeiss (p < 0.001), and Optovue versus Zeiss (p = 0.046). For the Optovue device, FAZ measurements were significantly different between 3 mm (mean 220 mm2) and 6 mm (mean 239.3 mm2, p = 0.007) scans. All other devices showed no significant difference within scan modes. Conclusion Current OCT-A devices provide images that allow such measurements, but values showed significant differences between devices and, for the Optovue instrument, even within scan modes. The data for OCTA measurements cannot be transferred interchangeably between the devices. Therefore, a patient should always be measured with the same device.

scholarly journals Extratympanic Observation of Middle and Inner Ear Structures in Rodents Using Optical Coherence Tomography

2020 ◽  
Vol 13 (2) ◽  
pp. 106-112 ◽  
Author(s):  
Se-Joon Oh ◽  
Il-Woo Lee ◽  
Soo-Geun Wang ◽  
Soo-Keun Kong ◽  
Hong-Ki Kim ◽  
...  
Keyword(s):  
Animal Model ◽  
Optical Coherence Tomography ◽  
Inner Ear ◽  
Oval Window ◽  
Diagnostic Information ◽  
Optical Coherence ◽  
Swept Source ◽  
Diagnostic Technology ◽  
Swept Source Oct ◽  
Rats And Mice

Objectives. This study aimed to investigate whether optical coherence tomography (OCT) provides useful information about the microstructures of the middle and inner ear via extratympanic approach and thereby could be utilized as an alternative diagnostic technology in ear imaging.Methods. Five rats and mice were included, and the swept-source OCT system was applied to confirm the extent of visibility of the middle and inner ear and measure the length or thickness of the microstructures in the ear. The cochlea was subsequently dissected following OCT and histologically evaluated to compare with the OCT images.Results. The middle ear microstructures such as ossicles, stapedial artery and oval window through the tympanic membrane with the OCT could be confirmed in both rats and mice. It was also possible to obtain the inner ear images such as each compartment of the cochlea in the mice, but the bone covering bulla needed to be removed to visualize the inner ear structures in the rats which had thicker bulla. The bony thickness covering the cochlea could be measured, which showed no significant differences between OCT and histologic image at all turns of cochlea.Conclusion. OCT has been shown a promising technology to assess real-time middle and inner ear microstructures noninvasively with a high-resolution in the animal model. Therefore, OCT could be utilized to provide additional diagnostic information about the diseases of the middle and inner ear.

scholarly journals Swept-Source Optical Coherence Tomography Detecting Intraoperative Acute Descemet's Fold Formation

2016 ◽  
Vol 7 (2) ◽  
pp. 354-358
Author(s):  
Yu Ichioka ◽  
Akihito Uji ◽  
Nagahisa Yoshimura
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Swept Source ◽  
En Face Oct ◽  
En Face ◽  
Descemet's Membrane ◽  
Descemet’S Membrane ◽  
Oct Imaging ◽  
Fold Formation ◽  
B Scan Images

Background: To present an intraoperative acute Descemet’s fold formation using swept-source optical coherence tomography (SS-OCT) imaging. Case Report: A 67-year-old man complaining of reduced visual acuity in the left eye. A 25-gauge pars plana vitrectomy combined with phacoemulsification cataract surgery was performed to remove the vitreomacular traction. When hydro-sealing was performed, striae rapidly spread in the cornea. SS-OCT B-scan images performed on postoperative day 1 revealed a wavy Descemet’s membrane that might correspond to Descemet’s folds. Pairs of hypo- and hyperreflective narrow lesions running from the wavy Descemet’s membrane to almost half of the thickness of the whole cornea were observed. En face OCT imaging clearly showed the stromal fold, which continuously spread from the Descemet’s fold. Conclusion: The stromal fold might be due to the focal bulge of the stroma posteriorly caused by the rapid volume increase of the stroma which could push Descemet’s membrane posteriorly, thereby forming a wavy Descemet’s membrane layer.

Optical Coherence Tomography in Vitreoretinal Interface Disorders

2018 ◽  
pp. 236-243
Keyword(s):  
Optical Coherence Tomography ◽  
Time Domain ◽  
Treatment Modalities ◽  
Optical Coherence ◽  
Vitreoretinal Interface ◽  
Swept Source ◽  
Appearance Time ◽  
Swept Source Oct ◽  
New Treatment ◽  
Pathologic Processes

Optical coherence tomography (OCT), which is in use for about 20 years, facilitated the evaluation of the vitreoretinal interface, improved our understanding of its pathologic processes, and paved the way to new treatment approaches. By order of appearance, time-domain, spectral-domain, and swept-source OCT technologies redefined vitreoretinal interface disorders and their treatment modalities.

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