The biological predisposition to obesity: beyond the thrifty genotype scenario

2007 ◽  
Vol 31 (9) ◽  
pp. 1337-1339 ◽  
Author(s):  
C Bouchard
Keyword(s):  
Thrifty Genotype ◽  
Biological Predisposition

The G Protein β3 Subunit Gene (GNB3) 825T Allele - a Thrifty Genotype

2003 ◽  
Vol 4 (4) ◽  
pp. 337-342
Author(s):  
C. Naber ◽  
R. Erbel ◽  
W. Siffert
Keyword(s):  
G Protein ◽  
Subunit Gene ◽  
Thrifty Genotype ◽  
825T Allele

Genetic explanations 1: the thrifty genotype and its variants

2019 ◽  
pp. 38-57
Author(s):  
Raj S. Bhopal
Keyword(s):  
Insulin Resistance ◽  
South Asians ◽  
Obesity Prevalence ◽  
Thrifty Genotype ◽  
Modern Times ◽  
Food Scarcity ◽  
Food Shortages ◽  
New Ideas ◽  
Mitochondrial Efficiency ◽  
The Brain

The thrifty genotype proposes that populations susceptible to CVD and DM2 have been subjected to intermittent, serious food shortages and have evolved to cope, e.g. through insulin resistance. This means their glucose is not readily entering the muscle to be used there but is preferentially used by the brain and liver. Glucose is converted to fat in the liver and stored for times of food scarcity. This thrifty state is not, however, beneficial in modern times where food is plentiful. This hypothesis remains a common explanation, including for South Asians’ susceptibility to DM2. The hypothesis has lost support, mostly because of lack of confirmatory empirical data, but has sparked-off new ideas, e.g. the mitochondrial efficiency hypothesis as an adaptation to climatic change, and the predation release hypothesis which sees diminishing need for leanness and agility as triggering higher obesity prevalence. These newer ideas need more research.

Decline in Incidence of Epidemic Glucose Intolerance in Nauruans: Implications for the “Thrifty Genotype”

1991 ◽  
Vol 133 (11) ◽  
pp. 1093-1104 ◽  
Author(s):  
Gary K. Dowse ◽  
Paul Z. Zimmet ◽  
Caroline F. Finch ◽  
Veronica R. Collins
Keyword(s):  
Glucose Intolerance ◽  
Thrifty Genotype

scholarly journals The “Thrifty Genotype” in 19981

2009 ◽  
Vol 57 (5) ◽  
pp. 2-9 ◽  
Author(s):  
James V. Neel
Keyword(s):  
Thrifty Genotype

scholarly journals Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

Diabetologia ◽  
2009 ◽  
Vol 52 (9) ◽  
pp. 1846-1851 ◽  
Author(s):  
L. Southam ◽  
N. Soranzo ◽  
S. B. Montgomery ◽  
T. M. Frayling ◽  
M. I. McCarthy ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Evidence Based ◽  
Thrifty Genotype ◽  
Obesity Susceptibility ◽  
Thrifty Genotype Hypothesis ◽  
Diabetes And Obesity

scholarly journals Birth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype?

BMJ ◽  
1994 ◽  
Vol 308 (6934) ◽  
pp. 942-945 ◽  
Author(s):  
D R McCance ◽  
D J Pettitt ◽  
R L Hanson ◽  
L T H Jacobsson ◽  
W C Knowler ◽  
...  
Keyword(s):  
Birth Weight ◽  
Insulin Dependent Diabetes ◽  
Thrifty Genotype ◽  
Thrifty Phenotype ◽  
Insulin Dependent
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