scholarly journals Correlation of Snail expression with histological grade and lymph node status in breast carcinomas

Oncogene ◽  
2002 ◽  
Vol 21 (20) ◽  
pp. 3241-3246 ◽  
Author(s):  
Maria J Blanco ◽  
Gema Moreno-Bueno ◽  
David Sarrio ◽  
Annamaria Locascio ◽  
Amparo Cano ◽  
...  
Keyword(s):  
Lymph Node ◽  
Histological Grade ◽  
Lymph Node Status ◽  
Breast Carcinomas ◽  
Snail Expression ◽  
Node Status

scholarly journals Stromal expression of CD10 in breast carcinoma and its correlation with clinicopathological parameters

2019 ◽  
Vol 08 (01) ◽  
pp. 18-21
Author(s):  
Ashish Nitin Dhande ◽  
Siddhi Gaurish Sinai Khandeparkar ◽  
Avinash R. Joshi ◽  
Maithili Mandar Kulkarni ◽  
Nidhi Pandya ◽  
...  
Keyword(s):  
Lymph Node ◽  
Histological Grade ◽  
Tumor Grade ◽  
Clinicopathological Parameters ◽  
Lymph Node Status ◽  
Breast Carcinomas ◽  
Independent Prognostic Marker ◽  
Immunohistochemical Markers ◽  
Node Status ◽  
Cd10 Expression

Abstract Introduction: Breast cancer is the foremost cause of death in women worldwide with more than one million cases occurring annually. Aim: This study was conducted to study the stromal CD10 expression in breast carcinomas (BCa) and its correlation with various prognostic factors such as tumor size, histological grade, lymph node status, estrogen receptor (ER), progesterone receptor (PR), HER2neu, and Ki67 status. Materials and Methods: Sixty cases of BCa diagnosed between 2013 and 2015 were included in the study. Stromal expression of CD10 was studied on entire section of selected BCa blocks for all cases. A technique of manual tissue microarray was employed for the analysis of expression of immunohistochemical markers ER, PR, and HER2/Neu and Ki67 in all cases. Results were subjected to statistical analysis. Results: Stromal CD10 positivity was seen in 78.3% cases, out of which 53.3% of cases were strongly positive, and 25.0% cases were weakly positive. Positivity for ER, PR, HER2, and Ki67 was 31.7%, 33.3%, 65%, and 75%, respectively. Stromal expression of CD10 was found to be significantly associated with increasing tumor grade, lymph node status, HER2neu positivity, ER negativity, and Ki67 positivity. CD10 stromal expression was seen mainly in PR negative BCa cases; however, it was statistically insignificant. It was noted that CD10 stromal positivity increased with increasing grade. Conclusion: CD10 can be used as an independent prognostic marker and should be included in routine histopathology report. CD10 could act as a potential target for newer drug development.

Sentinel Node Status and Tumor Characteristics: A Study of 234 Invasive Breast Carcinomas

2005 ◽  
Vol 129 (1) ◽  
pp. 82-84 ◽  
Author(s):  
Ying Cao ◽  
Gladell P. Paner ◽  
Prabha B. Rajan
Keyword(s):  
Lymph Node ◽  
Tumor Size ◽  
Lymphovascular Invasion ◽  
Frozen Section ◽  
Paraffin Section ◽  
Lymph Node Status ◽  
Axillary Lymph ◽  
Breast Carcinomas ◽  
Node Status ◽  
Size Grade

Abstract Context.—Axillary lymph node status is the most important prognostic factor in patients with breast cancer. Tumor size and lymph node status, the most reliable pathologic bases of the tumor staging system, are practical parameters for estimating survival status. With the advent of lymphatic mapping and sentinel node (SN) identification, there is potential for a more efficient and sensitive evaluation of the axillary lymph node status. Objective.—To correlate SN status with tumor size, grade, and lymphovascular invasion. Design.—We examined 234 patients with unifocal breast carcinomas measuring 25 mm or less as detected by preoperative ultrasound during the period May 1998 through December 2002. Sentinel nodes were examined by frozen section and paraffin section as per protocol. Results.—Of the 234 patients, SN was identified in 221 (94.5%). An average of 1.38 SNs were examined per patient. Seventy-seven of 221 patients were SN positive on paraffin section. Sixty-six (85.7%) of these 77 cases could be correctly diagnosed as positive for metastatic carcinoma on frozen section. Two cases reported as positive on paraffin section were reported as suspicious on frozen section. Logistic regression indicated that tumor size, grade, and lymphovascular invasion were all significantly associated with SN status (P < .001). Conclusions.—Tumor size, grade, and lymphovascular invasion were significantly associated with SN status in unifocal invasive breast carcinoma.

Somatic DNA Alterations in Breast Carcinomas of Different Lymph-Node Status by DNA Fingerprint Analyses

1998 ◽  
Vol 103 (2) ◽  
pp. 149-154 ◽  
Author(s):  
Regine Schneider-Stock ◽  
Thomas Günther ◽  
Albert Roessner ◽  
Jörg T Epplen
Keyword(s):  
Lymph Node ◽  
Dna Fingerprint ◽  
Lymph Node Status ◽  
Breast Carcinomas ◽  
Node Status ◽  
Dna Alterations

Morphologic Spectrum of Estrogen Receptor–Negative Breast Carcinoma

2002 ◽  
Vol 126 (3) ◽  
pp. 325-330
Author(s):  
Richard Scawn ◽  
Sami Shousha
Keyword(s):  
Estrogen Receptor ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Lymph Node Status ◽  
Tumor Diameter ◽  
Axillary Lymph ◽  
Prolactin Receptors ◽  
Breast Carcinomas ◽  
Node Status ◽  
Node Metastases

Abstract Context.—Estrogen receptor (ER)-negative breast carcinomas are a heterogeneous group of breast cancers that are generally thought to be aggressive. Objective.—To determine the morphologic and immunohistochemical spectrum of a consecutive series of ER-negative breast carcinomas, in an attempt to understand the pathogenesis and behavior of these lesions. Design.—Seventy-four consecutive cases of ER-negative invasive carcinomas were studied. Hematoxylin-eosin–stained sections were reviewed, and new sections were stained for c-erbB-2, p53, vimentin, and androgen and prolactin receptors. The findings were correlated with the axillary lymph node status as a measure of tumor aggressiveness. Setting.—The histopathology department of a tertiary referral teaching hospital. Results.—The tumors included 50 (68%) invasive ductal carcinomas, 21 (28%) medullary/atypical medullary carcinomas, and 1 each of invasive lobular, apocrine, and papillary carcinoma. Some of the invasive ductal cases had distinctive features that are described in this report. Maximum tumor diameter varied between 5 and 100 mm. Sixty tumors (81%) were grade 3, 13 (18%) were grade 2, and 1 (1%) was grade 1. Of the 60 cases in which the axillary node status was known, 34 (57%) had metastases, and 26 did not. Tumors associated with positive nodes were significantly larger than those associated with negative nodes (37.2 vs 17.8 mm, P < .001). A higher percentage of node-negative tumors were c-erbB-2 positive (42% vs 21%, P < .05). There were no differences between the 2 groups with regard to histologic type, tumor grade, or the expression of p53, vimentin, or androgen or prolactin receptors Conclusions.—Many ER-negative breast carcinomas have distinctive microscopic features. Not all ER-negative tumors are aggressive, as judged by the absence of lymph node metastases in 43% of cases in this series. Tumor size is the most important indicator for the likelihood of the presence of lymph node metastases. The wide range of tumor sizes encountered in this series suggests that the ER status of a tumor is determined early in its natural history and supports the existence of 2 separate pathways for the development of ER-negative and ER-positive breast carcinomas.

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