Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation

Lin-Lin Kang; Dong-Mei Zhang; Chun-Hua Ma; Jian-Hua Zhang; Ke-Ke Jia; Jia-Hui Liu; Rong Wang; Ling-Dong Kong

doi:10.1038/srep27460

Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation

Scientific Reports ◽

10.1038/srep27460 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 37

Author(s):

Lin-Lin Kang ◽

Dong-Mei Zhang ◽

Chun-Hua Ma ◽

Jian-Hua Zhang ◽

Ke-Ke Jia ◽

...

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Cardiac Inflammation ◽

Nlrp3 Inflammasome Activation

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Lp-PLA2 inhibition prevents Ang II-induced cardiac inflammation and fibrosis by blocking macrophage NLRP3 inflammasome activation

Acta Pharmacologica Sinica ◽

10.1038/s41401-021-00703-7 ◽

2021 ◽

Author(s):

Si-lin Lv ◽

Zi-fan Zeng ◽

Wen-qiang Gan ◽

Wei-qi Wang ◽

Tie-gang Li ◽

...

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Ang Ii ◽

Cardiac Inflammation ◽

Nlrp3 Inflammasome Activation

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The SGK1 inhibitor EMD638683, prevents Angiotensin II–induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ◽

10.1016/j.bbadis.2017.10.001 ◽

2018 ◽

Vol 1864 (1) ◽

pp. 1-10 ◽

Cited By ~ 31

Author(s):

Wenqiang Gan ◽

Jingyuan Ren ◽

Tiegang Li ◽

Silin Lv ◽

Chenghe Li ◽

...

Keyword(s):

Angiotensin Ii ◽

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Cardiac Inflammation ◽

Nlrp3 Inflammasome Activation

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α1-AR overactivation induces cardiac inflammation through NLRP3 inflammasome activation

Acta Pharmacologica Sinica ◽

10.1038/s41401-019-0305-x ◽

2019 ◽

Vol 41 (3) ◽

pp. 311-318 ◽

Cited By ~ 3

Author(s):

Jun-zhou Xin ◽

Ji-min Wu ◽

Guo-min Hu ◽

Hui-jun Gu ◽

Ye-nan Feng ◽

...

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Cardiac Inflammation ◽

Nlrp3 Inflammasome Activation

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248-LB: Deficiency of APPL1 in Macrophages Triggers Adipose Tissue Inflammation and Insulin Resistance by Potentiating NLRP3 Inflammasome Activation

Diabetes ◽

10.2337/db19-248-lb ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 248-LB ◽

Cited By ~ 1

Author(s):

KELVIN K.L. WU ◽

AIMIN XU ◽

KENNETH K. CHENG

Keyword(s):

Insulin Resistance ◽

Adipose Tissue ◽

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Adipose Tissue Inflammation ◽

Tissue Inflammation ◽

Nlrp3 Inflammasome Activation

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Faculty Opinions recommendation of Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717980435.793471692 ◽

2013 ◽

Author(s):

Laurel Lenz ◽

Rebecca Schmidt

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation

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Faculty Opinions recommendation of Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718039111.793480657 ◽

2013 ◽

Author(s):

Douglas Green ◽

Jennifer Martinez

Keyword(s):

Fatty Acids ◽

Nlrp3 Inflammasome ◽

Metabolic Disorder ◽

Inflammasome Activation ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Nlrp3 Inflammasome Activation

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Faculty Opinions recommendation of 3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718184539.793519737 ◽

2016 ◽

Author(s):

Eicke Latz

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation

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Faculty Opinions recommendation of Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726362863.793559823 ◽

2019 ◽

Author(s):

Paras Anand

Keyword(s):

Nlrp3 Inflammasome ◽

Dextran Sulfate ◽

Dextran Sulfate Sodium ◽

Experimental Colitis ◽

Dimethyl Fumarate ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation

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Faculty Opinions recommendation of Hemin and cobalt protoporphyrin inhibit NLRP3 inflammasome activation by enhancing autophagy: A novel mechanism of inflammasome regulation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726766143.793523875 ◽

2016 ◽

Author(s):

Mark A Williams

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation ◽

Cobalt Protoporphyrin

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Faculty Opinions recommendation of Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734279765.793559839 ◽

2019 ◽

Author(s):

Paras Anand

Keyword(s):

Nlrp3 Inflammasome ◽

Inflammasome Activation ◽

Nlrp3 Inflammasome Activation

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