Synthesis and in vitro enzyme activity of peptide derivatives of bacterial cell wall biosynthesis inhibitors

2000 ◽  
pp. 2023-2036 ◽  
Author(s):  
Russell J. Cox ◽  
Helen Jenkins ◽  
James A. Schouten ◽  
Rosie A. Stentiford ◽  
Katrina J. Wareing
Keyword(s):  
Cell Wall ◽  
Enzyme Activity ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Cell Wall Biosynthesis ◽  
Biosynthesis Inhibitors ◽  
Peptide Derivatives ◽  
Derivatives Of

Pulvinones as bacterial cell wall biosynthesis inhibitors

2006 ◽  
Vol 16 (1) ◽  
pp. 176-180 ◽  
Author(s):  
Schuyler Antane ◽  
Craig E. Caufield ◽  
William Hu ◽  
David Keeney ◽  
Pornpen Labthavikul ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Cell Wall Biosynthesis ◽  
Biosynthesis Inhibitors

Role of kallikrein-kinin system in pathogenesis of bacterial cell wall-induced inflammation

1991 ◽  
Vol 260 (2) ◽  
pp. G213-G219 ◽  
Author(s):  
R. A. DeLa Cadena ◽  
K. J. Laskin ◽  
R. A. Pixley ◽  
R. B. Sartor ◽  
J. H. Schwab ◽  
...  
Keyword(s):  
Cell Wall ◽  
Acute Phase ◽  
Bacterial Cell ◽  
Chronic Phase ◽  
Bacterial Cell Wall ◽  
Kinin System ◽  
Kallikrein Kinin System ◽  
Bacterial Products

The plasma kallikrein-kinin system is activated in Gram-negative sepsis and typhoid fever, two diseases in which bacterial products have been shown to initiate inflammation. Because a single intraperitoneal injection of bacterial cell wall peptidoglycan-polysaccharide polymers from group A steptococci (PG-APS) into a Lewis rat produces a syndrome of relapsing polyarthritis and anemia, we investigated changes in the role of the kallikrein-kinin system in this model of inflammation. Coagulation studies after injection of PG-APS revealed an immediate and persistent decrease in prekallikrein levels. High-molecular-weight kininogen levels decreased significantly during the acute phase and correlated with the severity of arthritis. Factor XI levels were decreased only during the acute phase. Antithrombin III levels remained unchanged, indicating that neither decreased hepatic synthesis nor disseminated intravascular coagulation caused the decreased plasma contact factors. Plasma T-kininogen (an acute phase protein) was significantly elevated during the chronic phase. PG-APS failed to activate the contact system in vitro. Thus the kallikrein-kinin system plays an important role in this experimental model of inflammation, suggesting that activation of this system may play a role in the pathogenesis of inflammatory bowel disease and rheumatoid arthritis in which bacterial products might be etiologically important.

scholarly journals Synthesis of Analogs of D-Ala--D-Ala as Potential Inhibitors of Bacterial Cell Wall Biosynthesis.

1984 ◽  
Vol 38b ◽  
pp. 5-14 ◽  
Author(s):  
Erik A. Hagen ◽  
Tom Bergan ◽  
Arne J. Aasen ◽  
Lester A. Mitscher ◽  
Daniel T. W. Chu
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Cell Wall Biosynthesis ◽  
Potential Inhibitors

scholarly journals A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis

2001 ◽  
Vol 98 (4) ◽  
pp. 1427-1431 ◽  
Author(s):  
W. Lee ◽  
M. A. McDonough ◽  
L. P. Kotra ◽  
Z.-H. Li ◽  
N. R. Silvaggi ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Cell Wall Biosynthesis

scholarly journals Synthesis of 9-Dechlorochrysophaentin A Enables Studies Revealing Bacterial Cell Wall Biosynthesis Inhibition Phenotype in B. subtilis

2020 ◽  
Vol 142 (38) ◽  
pp. 16161-16166
Author(s):  
Christopher R. Fullenkamp ◽  
Yen-Pang Hsu ◽  
Ellen M. Quardokus ◽  
Gengxiang Zhao ◽  
Carole A. Bewley ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Cell Wall Biosynthesis
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