Backbone-extended pyrrolidine peptide nucleic acids (bepPNA): design, synthesis and DNA/RNA binding studies

2005 ◽  
pp. 495 ◽  
Author(s):  
T. Govindaraju ◽  
Vaijayanti A. Kumar
Keyword(s):  
Nucleic Acids ◽  
Rna Binding ◽  
Peptide Nucleic Acids ◽  
Binding Studies ◽  
Design Synthesis

Conformationally restricted cationic polyamide analogs of nucleic acids: Design, synthesis, and DNA/RNA binding studies

2004 ◽  
Vol 76 (7-8) ◽  
pp. 1599-1603 ◽  
Author(s):  
V. A. Kumar ◽  
Moneesha D'Costa ◽  
P. S. Lonkar ◽  
P. S. Pallan ◽  
K. N. Ganesh ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Water Solubility ◽  
Rna Binding ◽  
Binding Studies ◽  
Design Synthesis ◽  
Conformationally Restricted ◽  
Nucleic Acid Analogs ◽  
Conformational Preferences

The remarkable medicinal importance of the achiral, acyclic, and uncharged aminoethylglycyl peptide nucleic acids (aegPNAs) as DNA/RNA mimics has challenged chemists to circumvent the limitations of their in vivo efficacy. In this context, we have designed conformationally restricted five- and six-membered cyclic PNA analogs by introduction of chemical bridges in aegPNAs leading to a large variety of structures with defined configurations and conformational preferences, effecting concomitant installation of a positive charge in the backbone. The synthesis and biophysical properties of these cationic aminoethylprolyl PNAs, pyrrolidine PNAs, and piperidine PNAs endowed with increased water solubility and affinity toward target nucleic acids is presented. These nucleic acid analogs as lead structures are a part of a chemical evolution process that might give rise to a synthetic nucleic acid analog having optimum properties for medicinal applications.

scholarly journals Synthetic, Structural, and RNA Binding Studies on 2‐Aminopyridine‐Modified Triplex‐Forming Peptide Nucleic Acids

2019 ◽  
Vol 25 (17) ◽  
pp. 4367-4372 ◽  
Author(s):  
Venubabu Kotikam ◽  
Scott D. Kennedy ◽  
James A. MacKay ◽  
Eriks Rozners
Keyword(s):  
Nucleic Acids ◽  
Rna Binding ◽  
Peptide Nucleic Acids ◽  
Binding Studies

Incorporating 2-Thiouracil into Short Double-Stranded RNA-Binding Peptide Nucleic Acids for Enhanced Recognition of A-U Pairs and for Targeting a MicroRNA Hairpin Precursor

Biochemistry ◽  
2019 ◽  
Vol 58 (32) ◽  
pp. 3444-3453 ◽  
Author(s):  
Alan Ann Lerk Ong ◽  
Desiree-Faye Kaixin Toh ◽  
Manchugondanahalli S. Krishna ◽  
Kiran M. Patil ◽  
Katsutomo Okamura ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Rna Binding ◽  
Peptide Nucleic Acids ◽  
Binding Peptide ◽  
Double Stranded Rna ◽  
Hairpin Precursor

Synthesis and RNA-Binding Properties of Extended Nucleobases for Triplex-Forming Peptide Nucleic Acids

2019 ◽  
Vol 84 (21) ◽  
pp. 13276-13298
Author(s):  
Ilze Kumpina ◽  
Nikita Brodyagin ◽  
James A. MacKay ◽  
Scott D. Kennedy ◽  
Martins Katkevics ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Rna Binding ◽  
Peptide Nucleic Acids ◽  
Binding Properties
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