A paramagnetic Cu(i)/Cu(ii)/Zn(ii) coordination polymer with multiple CN-binding modes and its solid-state NMR characterization

2006 ◽  
pp. 744 ◽  
Author(s):  
Liang Ouyang ◽  
Pedro M. Aguiar ◽  
Raymond J. Batchelor ◽  
Scott Kroeker ◽  
Daniel B. Leznoff
Keyword(s):  
Solid State ◽  
Coordination Polymer ◽  
Solid State Nmr ◽  
Binding Modes ◽  
Nmr Characterization

A (−)-Menthyl Bonded Silica Phase for Chiral Separations:  Synthesis and Solid State NMR Characterization

1997 ◽  
Vol 69 (9) ◽  
pp. 1756-1762 ◽  
Author(s):  
Bernard Lynch ◽  
Jeremy D. Glennon ◽  
Christof Tröltzsch ◽  
Ulf Menyes ◽  
Matthias Pursch ◽  
...  
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Chiral Separations ◽  
Silica Phase ◽  
Nmr Characterization

scholarly journals 14N1H HMQC Solid-State NMR as a Powerful Tool to Study Amorphous Formulations – an Exemplary Study of Paclitaxel Loaded Polymer Micelles

2020 ◽  
Author(s):  
Marvin Grüne ◽  
Robert Luxenhofer ◽  
Dinu Iuga ◽  
Steven P. Brown ◽  
Ann-Christin Pöppler
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Chemical Shifts ◽  
Mas Nmr ◽  
Cancer Drug ◽  
Polymer Micelles ◽  
Promising Tool ◽  
Nmr Characterization

We present <sup>14</sup>N-<sup>1</sup>H HMQC MAS NMR experiments in the solid state as a promising tool to study amorphous formulations. Poly(2-oxazoline) based polymer micelles loaded with different amounts of the cancer drug paclitaxel serve to highlight the possibilities offered by these experiments: While the very similar <sup>15</sup>N chemical shifts hamper a solid-state NMR characterization based on this nucleus, <sup>14</sup>N is a very versatile alternative. <sup>14</sup>N-<sup>1</sup>H HMQC experiments yield well-separated signals, which are spread over a large ppm range, provide information on the symmetry of the nitrogen environment and probe <sup>14</sup>N-<sup>1</sup>H through-space proximities.

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