Clays and Clay Minerals
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Published By Springer-Verlag

1552-8367, 0009-8604

Author(s):  
Jiří Hybler ◽  
Zdeněk Dolníček ◽  
Jiří Sejkora ◽  
Martin Števko

Author(s):  
Margarita Darder ◽  
Jing He ◽  
Laurent Charlet ◽  
Eduardo Ruiz-Hitzky ◽  
Pilar Aranda

AbstractThe present study introduces an overview of gentamicin-clay mineral systems for applications in biomedicine and then focuses on the development of a series of gentamicin/clay hybrid materials to be used as the bioactive phase of hydroxypropylmethylcellulose (HPMC) to produce bionanocomposite membranes possessing antimicrobial activity of interest in wound-dressing applications. Gentamicin (Gt) was adsorbed from aqueous solutions into a montmorillonite (Cloisite®-Na+) to produce intercalation compounds with tunable content of the antibiotic. The hybrids were characterized by CHN chemical analysis, energy-dispersive X-ray analysis, X-ray diffraction, Fourier-transform infrared spectroscopy, and thermogravimetric analysis, confirming the intercalation of Gt by an ion-exchange mechanism. The release of Gt from the hybrids was tested in water and in buffer solution to check their stability. Hybrids with various amounts of Gt were incorporated into a HPMC matrix at various loadings and processed as films by the casting method. The resulting Gt-clay/HPMC bionanocomposites were characterized by means of field-emission scanning electron microscopy, and were also evaluated for their water-adsorption and mechanical properties to confirm their suitability for wound-dressing applications. The antimicrobial activity of the bionanocomposite films was tested in vitro toward various microorganisms (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium, Acinetobacter baumannii, and Klebsiella pneumonia), showing a complete bacterial reduction even in films with small Gt contents.


Author(s):  
M. Saleh ◽  
N. Prajapati ◽  
A. Karan ◽  
N. Rahman ◽  
A. Stavitskaya ◽  
...  

Author(s):  
Ahmad Khan ◽  
Mohammad Saleem Akhtar ◽  
Saba Akbar ◽  
Khalid Saifullah Khan ◽  
Mazhar Iqbal ◽  
...  
Keyword(s):  

Author(s):  
Sandrine Ragu ◽  
Olivier Piétrement ◽  
Bernard S. Lopez

Author(s):  
Ekaterina Naumenko ◽  
Elena Zakirova ◽  
Ivan Guryanov ◽  
Farida Akhatova ◽  
Mikhail Sergeev ◽  
...  

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