Some uses of transition metal complexes as anti-cancer and anti-HIV agents

2007 ◽  
pp. 4884 ◽  
Author(s):  
Raymond Wai-Yin Sun ◽  
Dik-Lung Ma ◽  
Ella Lai-Ming Wong ◽  
Chi-Ming Che
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Anti Cancer ◽  
Anti Hiv Agents ◽  
Anti Hiv

SYNTHESIS AND CHARACTERIZATION FOR VARIOUS BIOLOGICAL ACTIVITIES OF TRANSITION METAL COMPLEXES OF QUERCETIN

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (09) ◽  
pp. 15-22
Author(s):  
M. K Gadhwal ◽  
◽  
S. C Patil ◽  
P Dmello ◽  
U Joshi .
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Biological Activities ◽  
Hydroxyl Groups ◽  
Structural Modifications ◽  
Cu Complex ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Anti Inflammatory

Flavonoids are a group of polyphenolic compounds with multiple biological activities including antioxidant, anti-inflammatory and anti-cancer activities. The reduced bioavailability of flavonoids, however calls for structural modifications. Quercetin possesses multiple hydroxyl groups and an ability to chelate metal ions. Transition metal complexes have shown therapeutic promises in treatment of both inflammation and cancer. The present work describes synthesis of transition metal complexes of quercetin which resulted in the synthesis of the complexes of the type M2L which were characterized by IR and proton NMR. Although anti-oxidant and anti-inflammatory activity of the quercetin-Cu complex was higher than quercetin, the anticancer activity of the quercetin-Zn complex was much higher. A mechanism of action for the same is proposed.

Mechanochemical changes on cyclometalated Ir(iii) acyclic carbene complexes – design and tuning of luminescent mechanochromic transition metal complexes

2020 ◽  
Vol 7 (3) ◽  
pp. 786-794 ◽  
Author(s):  
Jingqi Han ◽  
Kin-Man Tang ◽  
Shun-Cheung Cheng ◽  
Chi-On Ng ◽  
Yuen-Kiu Chun ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Carbene Complexes ◽  
New Class

A new class of luminescent cyclometalated Ir(iii) complexes with readily tunable mechanochromic properties derived from the mechanically induced trans-to-cis isomerization have been developed.

Density Functional Calculations of EPR Parameter g Tensors of Some Transition Metal Complexes

2011 ◽  
Vol 2 (2) ◽  
pp. 139-141
Author(s):  
Vinita Prajapati ◽  
◽  
P.L.Verma P.L.Verma ◽  
Dhirendra Prajapati ◽  
B.K.Gupta B.K.Gupta
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Density Functional Calculations ◽  
Density Functional

Synthesis, Characterization and in vitro Biological Evaluation of a New Schiff Base Derived from Drug and its Complexes with Transition Metal Ions

2018 ◽  
Vol 69 (7) ◽  
pp. 1678-1681
Author(s):  
Amina Mumtaz ◽  
Tariq Mahmud ◽  
M. R. J. Elsegood ◽  
G. W. Weaver
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Free Ligand ◽  
Transition Metal Ions ◽  
Biological Evaluation ◽  
Pyridoxal Hydrochloride

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

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