A facile access to [60]fullerene-fused δ-lactones: unexpected reaction pathway of benzenediazonium-2-carboxylates controlled by organic bases

2009 ◽  
pp. 1769 ◽  
Author(s):  
Guan-Wu Wang ◽  
Bo Zhu
Keyword(s):  
Reaction Pathway ◽  
Organic Bases ◽  
Unexpected Reaction

Reaction Pathways to 2-Aminothiophenes and Thiophene-3-carbonitriles

2009 ◽  
Vol 62 (5) ◽  
pp. 402 ◽  
Author(s):  
Luigi Aurelio ◽  
Bernard L. Flynn ◽  
Peter J. Scammells
Keyword(s):  
Comparative Studies ◽  
Reaction Pathway ◽  
Reaction Pathways ◽  
Synthesis And Characterization ◽  
The Past ◽  
Adenosine A1 ◽  
Unexpected Reaction ◽  
Potential Applications ◽  
A1 Receptor

Over the past two decades 2-amino-3-benzoylthiophenes have been found to act as allosteric enhancers of the adenosine A1 receptor (A1AR). As such, compounds of this type have potential applications in the therapy of a variety of disorders by enhancing A1AR activation. Initial studies in this field identified various 2-amino-3-benzoylthiophenes as potential leads and of these PD 81723 1a has become the benchmark for comparative studies due to its favourable ratio of allosteric enhancement to antagonism. Surprisingly the synthesis and characterization of PD 81723 1a has not been previously reported. Herein we report the synthesis and characterization of this important A1AR allosteric enhancer. As part of this study we also found an unexpected reaction pathway to 2-phenylthiophene-3-carbonitriles.

Development of an unexpected reaction pathway for the synthesis of 1,2,4-trisubstituted pyrrolo[1,2-a]quinoxalines through palladium-catalyzed cascade reactions

Tetrahedron ◽  
2017 ◽  
Vol 73 (12) ◽  
pp. 1633-1639 ◽  
Author(s):  
Ali Keivanloo ◽  
Atena Soozani ◽  
Mohammad Bakherad ◽  
Mahdi Mirzaee ◽  
Hadi Amiri Rudbari ◽  
...  
Keyword(s):  
Reaction Pathway ◽  
Cascade Reactions ◽  
Unexpected Reaction ◽  
Palladium Catalyzed

scholarly journals Unexpected Reaction Pathway for butyrylcholinesterase-catalyzed inactivation of “hunger hormone” ghrelin

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Jianzhuang Yao ◽  
Yaxia Yuan ◽  
Fang Zheng ◽  
Chang-Guo Zhan
Keyword(s):  
Reaction Pathway ◽  
Unexpected Reaction

An unexpected reaction pathway in the synthesis of the ABCE framework of strychnine-type alkaloids – A multidisciplinary study

2017 ◽  
Vol 1128 ◽  
pp. 230-238 ◽  
Author(s):  
Michal Šoral ◽  
Jozef Markus ◽  
Jana Doháňošová ◽  
Stanislava Šoralová ◽  
Dana Dvoranová ◽  
...  
Keyword(s):  
Reaction Pathway ◽  
Multidisciplinary Study ◽  
Unexpected Reaction

Unexpected reaction pathway during the palladation of 2,5-diphenylphosphacymantrene

2009 ◽  
Vol 694 (1) ◽  
pp. 72-76 ◽  
Author(s):  
Аllan G. Ginzburg ◽  
Vasily V. Bashilov ◽  
Fedor M. Dolgushin ◽  
Alexander F. Smol’yakov ◽  
Аlexander S. Peregudov ◽  
...  
Keyword(s):  
Reaction Pathway ◽  
Unexpected Reaction

scholarly journals Unexpected Reaction Pathway of the Alpha-Aminoalkyl Radical Derived from One-Electron Oxidation of S-Alkylglutathiones

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 877
Author(s):  
Tomasz Pedzinski ◽  
Krzysztof Bobrowski ◽  
Bronislaw Marciniak ◽  
Piotr Filipiak
Keyword(s):  
Flash Photolysis ◽  
Laser Flash Photolysis ◽  
High Resolution Mass Spectrometry ◽  
Reaction Pathway ◽  
Laser Flash ◽  
Ring Closure ◽  
Unexpected Reaction ◽  
Sulfur Containing ◽  
Resolution Mass ◽  
Intramolecular Ring

Laser flash photolysis and high-resolution mass spectrometry were used to investigate the mechanism of one-electron oxidation of two S-alkylglutathiones using 3-carboxybenzophenone (3CB) as a photosensitizer. This report indicates an unexpected reaction pathway of the α-aminoalkyl radical cation (αN+) derived from the oxidation of S-alkylglutathiones. Instead of a common hydrolysis reaction of αN+ reported earlier for methionine and other sulfur-containing aminoacids and peptides, an intramolecular ring-closure reaction was found for S-alkylglutathiones.

Skeletal isomerization of cyclohexene on AlPO4 catalysts

1983 ◽  
Vol 61 (11) ◽  
pp. 2567-2571 ◽  
Author(s):  
J. M. Campelo ◽  
A. Garcia ◽  
J. M. Gutierrez ◽  
D. Luna ◽  
J. M. Marinas
Keyword(s):  
Reaction Pathway ◽  
Strong Acid ◽  
Acid Sites ◽  
Skeletal Isomerization ◽  
Selectivity Factor ◽  
Irreversible Adsorption ◽  
Organic Bases ◽  
Selectivity Studies ◽  
Strong Acid Sites ◽  
Competitive Products

The skeletal isomerization of cyclohexene, in a microcatalytic pulse reactor, was investigated by using aluminium orthophosphates (Al/P = 1) as catalysts. An attempt has been made to correlate the isomerization activity with the acid properties of the solids, measured by means of the irreversible adsorption of different organic bases in cyclohexane, at 298 K, using a spectrophotometric method.Apparent rate constants were calculated in terms of the kinetic model of Bassett and Habgood. Selectivity studies led to the conclusion that 1-MCP and 3-MCP were competitive products. Correlation between the kinetic selectivity factor, σ, and the number of strong acid sites has been sought.A possible parallel reaction pathway is proposed, which agrees with both the observed rates and selectivities.

Cytochemical analysis of mast cell granules after poly-dl-lysine action

1978 ◽  
Vol 36 (2) ◽  
pp. 278-279
Author(s):  
R. Courtoy ◽  
L.J. Simar ◽  
J. Christophe
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Chemical Compounds ◽  
Cellular Membrane ◽  
Thin Sections ◽  
Organic Bases ◽  
Ferric Thiocyanate ◽  
Cytochemical Analysis ◽  
Mast Cell Granule ◽  
Amine Liberation

Several chemical compounds induce amine liberation from mast cells but do not necessarily provoque the granule expulsion. For example, poly-dl-lysine induces modifications of the cellular membrane permeability which promotes ion exchange at the level of mast cell granules. Few of them are expulsed but the majority remains in the cytoplasm and appears less dense to the electrons. A cytochemical analysis has been performed to determine the composition of these granules after the polylysine action.We have previously reported that it was possible to demonstrate polyanions on epon thin sections using a cetylpyridinium ferric thiocyanate method. Organic bases are selectively stained with cobalt thiocyanate and the sulfhydryle groups are characterized with a silver methenamine reaction. These techniques permit to reveal the mast cell granule constituents, i.e. heparin, biogenic amines and basic proteins.

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