Highly enhanced electrochemiluminescence based on pseudo triple-enzyme cascade catalysis and in situ generation of co-reactant for thrombin detection

The Analyst ◽  
2014 ◽  
Vol 139 (5) ◽  
pp. 1030-1036 ◽  
Author(s):  
Lijuan Xiao ◽  
Yaqin Chai ◽  
Ruo Yuan ◽  
Haijun Wang ◽  
Lijuan Bai
Keyword(s):  
Enzyme Cascade ◽  
Highly Sensitive ◽  
In Situ Generation ◽  
Amplification Strategy ◽  
Cascade Catalysis

In this work, a novel pseudo triple-enzyme cascade catalysis amplification strategy was employed to fabricate a highly sensitive electrochemiluminescence (ECL) aptasensor for thrombin (TB) detection.

In Situ Generation of Self-Enhanced Luminophore by β-Lactamase Catalysis for Highly Sensitive Electrochemiluminescent Aptasensor

2014 ◽  
Vol 86 (12) ◽  
pp. 5873-5880 ◽  
Author(s):  
Guo-Feng Gui ◽  
Ying Zhuo ◽  
Ya-Qin Chai ◽  
Yun Xiang ◽  
Ruo Yuan
Keyword(s):  
Highly Sensitive ◽  
In Situ Generation

A cyanide selective off–on fluorescent chemosensor with in vivo imaging in 100% water: solid probe preferred over in situ generation

RSC Advances ◽  
2014 ◽  
Vol 4 (19) ◽  
pp. 9656-9659 ◽  
Author(s):  
Sanju Das ◽  
Surajit Biswas ◽  
Santanu Mukherjee ◽  
Jaya Bandyopadhyay ◽  
Subhodip Samanta ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Fluorescent Chemosensor ◽  
Physiological Conditions ◽  
Highly Sensitive ◽  
In Situ Generation ◽  
Solid Probe

A solid non-toxic highly sensitive cyanide fluorosensor exhibits better biocompatibility over allied in situ complexes under physiological conditions.

An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes

The Analyst ◽  
2021 ◽  
Author(s):  
Huiying Xu ◽  
Lu Zheng ◽  
Yu Zhou ◽  
Bang-Ce Ye
Keyword(s):  
Early Cancer ◽  
Artificial Enzyme ◽  
Specific Detection ◽  
Heterogeneous Membrane ◽  
Enzyme Cascade ◽  
Early Cancer Diagnosis ◽  
Highly Sensitive ◽  
Noninvasive Biomarkers ◽  
Amplification Strategy ◽  
Cascade Amplification

Tumor-related exosomes, which are heterogeneous membrane-enclosed nanovesicles shed from cancer cells, have been widely recognized as potential noninvasive biomarkers for early cancer diagnosis. Herein, an artificial enzyme cascade amplification strategy...

In situ enrichment amplification strategy enabling highly sensitive formaldehyde gas sensor

2022 ◽  
Vol 354 ◽  
pp. 131206
Author(s):  
Lei Zhu ◽  
Jianan Wang ◽  
Jianwei Liu ◽  
Zhicheng Xu ◽  
Muhammad Salman Nasir ◽  
...  
Keyword(s):  
Gas Sensor ◽  
Highly Sensitive ◽  
Amplification Strategy

Highly diastereo- and enantioselective organocatalytic synthesis of trifluoromethylated erythritols based on the in situ generation of unstable trifluoroacetaldehyde

2021 ◽  
Author(s):  
Kazumasa Funabiki ◽  
Toshiya Gotoh ◽  
Ryunosuke Kani ◽  
Toshiyasu Inuzuka ◽  
Yasuhiro Kubota
Keyword(s):  
Trifluoromethyl Group ◽  
In Situ Generation

A highly diastereo- and enantioselective organocatalytic method to synthesise erythritols bearing a trifluoromethyl group has been investigated.

Recent advances in Minisci-type reactions and applications in organic synthesis

2020 ◽  
Vol 24 ◽  
Author(s):  
Wengui Wang ◽  
Shoufeng Wang
Keyword(s):  
Free Radical ◽  
Hydrogen Atom ◽  
Organic Synthesis ◽  
Radical Reactivity ◽  
Atom Loss ◽  
Radical Generation ◽  
In Situ Generation ◽  
Thermal Cleavage ◽  
Synthetic Chemist

Abstract:: Minisci-type reactions have become widely known as reactions that involve the addition of carbon-centered radicals to basic heteroarenes followed by formal hydrogen atom loss. While the originally developed protocols for radical generation remain in active use today, in recent years by a new array of radical generation strategies allow use of a wider variety of radical precursors that often operate under milder and more benign conditions. New transformations based on free radical reactivity are now available to a synthetic chemist looking to utilize a Minisci-type reaction. Radical-generation methods based on photoredox catalysis and electrochemistry, which utilize thermal cleavage or the in situ generation of reactive radical precursors, have become popular approaches. Our review will cover the remarkably literature that has appeared on this topic in recent 5 years, from 2015-01 to 2020-01, in an attempt to provide guidance to the synthetic chemist, on both the challenges that have been overcome and applications in organic synthesis.

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