An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes

The Analyst ◽  
2021 ◽  
Author(s):  
Huiying Xu ◽  
Lu Zheng ◽  
Yu Zhou ◽  
Bang-Ce Ye
Keyword(s):  
Early Cancer ◽  
Artificial Enzyme ◽  
Specific Detection ◽  
Heterogeneous Membrane ◽  
Enzyme Cascade ◽  
Early Cancer Diagnosis ◽  
Highly Sensitive ◽  
Noninvasive Biomarkers ◽  
Amplification Strategy ◽  
Cascade Amplification

Tumor-related exosomes, which are heterogeneous membrane-enclosed nanovesicles shed from cancer cells, have been widely recognized as potential noninvasive biomarkers for early cancer diagnosis. Herein, an artificial enzyme cascade amplification strategy...

Highly sensitive fluorescence quantification of intracellular telomerase activity by repeat G-rich DNA enhanced silver nanoclusters

2018 ◽  
Vol 6 (28) ◽  
pp. 4583-4591 ◽  
Author(s):  
Shan Huang ◽  
Huiqin Yao ◽  
Wenjing Wang ◽  
Jian-Rong Zhang ◽  
Jun-Jie Zhu
Keyword(s):  
Cancer Diagnosis ◽  
Therapeutic Target ◽  
Early Cancer ◽  
Telomerase Activity ◽  
Silver Nanoclusters ◽  
Early Cancer Diagnosis ◽  
Highly Sensitive

As an important biomarker for early cancer diagnosis and a valuable therapeutic target, the detection and monitoring of telomerase activity has attracted extensive attention.

Highly sensitive detection of nucleic acids using a cascade amplification strategy based on exonuclease III-assisted target recycling and conjugated polyelectrolytes

The Analyst ◽  
2018 ◽  
Vol 143 (18) ◽  
pp. 4267-4272 ◽  
Author(s):  
Biqing Bao ◽  
Yanrui Pan ◽  
Bingbing Gu ◽  
Jia Chen ◽  
Yu Xu ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Signal Amplification ◽  
Conjugated Polyelectrolytes ◽  
Exonuclease Iii ◽  
Target Recycling ◽  
Highly Sensitive ◽  
Exo Iii ◽  
Highly Sensitive Detection ◽  
Amplification Strategy ◽  
Cascade Amplification

A ratiometric and cascade amplification strategy that combines the signal amplification and effecitive FRET property of CPEs with the Exo III-assisted target recycling method has been developed for DNA detection.

Hydrothermal synthesis of core–shell structured TbPO4:Ce3+@TbPO4:Gd3+nanocomposites for magnetic resonance and optical imaging

2014 ◽  
Vol 43 (32) ◽  
pp. 12321-12328 ◽  
Author(s):  
Xiao-yan Kuang ◽  
Huan Liu ◽  
Wen-yong Hu ◽  
Yuan-zhi Shao
Keyword(s):  
Hydrothermal Synthesis ◽  
Magnetic Resonance ◽  
Cancer Diagnosis ◽  
Early Cancer ◽  
Core Shell ◽  
Promising Alternative ◽  
Non Invasive ◽  
Early Cancer Diagnosis ◽  
Alternative Approach ◽  
Highly Sensitive

Multi-modal imaging based on multifunctional nanoparticles provides deep, non-invasive and highly sensitive imaging and is a promising alternative approach that can improve the sensitivity of early cancer diagnosis.

A non-enzyme cascade amplification strategy for colorimetric assay of disease biomarkers

2017 ◽  
Vol 53 (65) ◽  
pp. 9055-9058 ◽  
Author(s):  
Jiuxing Li ◽  
Zhuangqiang Gao ◽  
Haihang Ye ◽  
Shulin Wan ◽  
Meghan Pierce ◽  
...  
Keyword(s):  
Colorimetric Assay ◽  
Detection Sensitivity ◽  
Disease Biomarkers ◽  
Enzyme Cascade ◽  
Amplification Strategy ◽  
Cascade Amplification

A non-enzyme cascade amplification strategy for colorimetric assay of disease biomarkers with substantially enhanced detection sensitivity has been developed.

Highly enhanced electrochemiluminescence based on pseudo triple-enzyme cascade catalysis and in situ generation of co-reactant for thrombin detection

The Analyst ◽  
2014 ◽  
Vol 139 (5) ◽  
pp. 1030-1036 ◽  
Author(s):  
Lijuan Xiao ◽  
Yaqin Chai ◽  
Ruo Yuan ◽  
Haijun Wang ◽  
Lijuan Bai
Keyword(s):  
Enzyme Cascade ◽  
Highly Sensitive ◽  
In Situ Generation ◽  
Amplification Strategy ◽  
Cascade Catalysis

In this work, a novel pseudo triple-enzyme cascade catalysis amplification strategy was employed to fabricate a highly sensitive electrochemiluminescence (ECL) aptasensor for thrombin (TB) detection.

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