Ultraselective electrochemiluminescence biosensor based on locked nucleic acid modified toehold-mediated strand displacement reaction and junction-probe

The Analyst ◽  
2014 ◽  
Vol 139 (23) ◽  
pp. 6109-6112 ◽  
Author(s):  
Xi Zhang ◽  
Jing Zhang ◽  
Dongzhi Wu ◽  
Zhijing Liu ◽  
Shuxian Cai ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid ◽  
Displacement Reaction ◽  
Strand Displacement ◽  
Junction Probe ◽  
Strand Displacement Reaction

scholarly journals A kinetically controlled platform for ligand-oligonucleotide transduction

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Qiu-Long Zhang ◽  
Liang-Liang Wang ◽  
Yan Liu ◽  
Jiao Lin ◽  
Liang Xu
Keyword(s):  
Nucleic Acid ◽  
Small Molecules ◽  
Signal Amplification ◽  
Kinetic Control ◽  
Displacement Reaction ◽  
Strand Displacement ◽  
Critical Pathway ◽  
Kinetically Controlled ◽  
Binding Sequence ◽  
Strand Displacement Reaction

AbstractLigand-oligonucleotide transduction provides the critical pathway to integrate non-nucleic acid molecules into nucleic acid circuits and nanomachines for a variety of strand-displacement related applications. Herein, a general platform is constructed to convert the signals of ligands into desired oligonucleotides through a precise kinetic control. In this design, the ligand-aptamer binding sequence with an engineered duplex stem is introduced between the toehold and displacement domains of the invading strand to regulate the strand-displacement reaction. Employing this platform, we achieve efficient transduction of both small molecules and proteins orthogonally, and more importantly, establish logical and cascading operations between different ligands for versatile transduction. Besides, this platform is capable of being directly coupled with the signal amplification systems to further enhance the transduction performance. This kinetically controlled platform presents unique features with designing simplicity and flexibility, expandable complexity and system compatibility, which may pave a broad road towards nucleic acid-based developments of sophisticated transduction networks.

Signal-off Photoelectrochemical Aptasensor for Kanamycin: strand displacement reaction combines p-n competition

2021 ◽  
pp. 338927
Author(s):  
Hanxiao Wang ◽  
Chi Zhang ◽  
Xinan An ◽  
Gaiping Li ◽  
Baoxian Ye ◽  
...  
Keyword(s):  
Displacement Reaction ◽  
Strand Displacement ◽  
Strand Displacement Reaction

An enzyme free electrochemical biosensor for sensitive detection of miRNA with a high discrimination factor by coupling the strand displacement reaction and catalytic hairpin assembly recycling

The Analyst ◽  
2017 ◽  
Vol 142 (21) ◽  
pp. 4116-4123 ◽  
Author(s):  
Juan Yao ◽  
Zhang Zhang ◽  
Zhenghua Deng ◽  
Youqiang Wang ◽  
Yongcan Guo
Keyword(s):  
Electrochemical Biosensor ◽  
Sensitive Detection ◽  
Selective Detection ◽  
Discrimination Factor ◽  
Displacement Reaction ◽  
Strand Displacement ◽  
High Discrimination ◽  
Catalytic Hairpin Assembly ◽  
Strand Displacement Reaction

Sensitive and selective detection of miRNA based on the toehold-mediated strand displacement reaction (SDR) and non-enzymatic catalytic hairpin reaction (CHA) recycling.

Determination of Adenosine Triphosphate by a Target Inhibited Catalytic Cycle Based on a Strand Displacement Reaction

2014 ◽  
Vol 47 (3) ◽  
pp. 478-491 ◽  
Author(s):  
Sheng Cheng ◽  
Bin Zheng ◽  
Mozhen Wang ◽  
Qing Zhao ◽  
Michael Hon-Wah Lam ◽  
...  
Keyword(s):  
Adenosine Triphosphate ◽  
Catalytic Cycle ◽  
Displacement Reaction ◽  
Strand Displacement ◽  
Strand Displacement Reaction
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