Dna Strand Displacement
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2021 ◽  
pp. 130645
Yinping Deng ◽  
Jun Du ◽  
Donghua Chen ◽  
Guo-Jiang Mao ◽  
Bin Yang ◽  

2021 ◽  
Vol 16 (6) ◽  
pp. 974-977
Jingjing Ma

In this paper, I construct an XOR logic gate based on DNA strand displacement reaction, and verify our design through corresponding biochemical experiment. I designed several different DNA strands. Based on two basic DNA strand displacement reaction mechanisms, by adding different input strands and taking the signal of FAM fluorescent group as the output, the XOR logic gate is realized. The result shows that DNA strand displacement technology has important application value in DNA computing, especially in the construction of DNA molecular logic gates.

Poliana A. C. Oliveira ◽  
João V. C. Teixeira ◽  
Renan A. Marks ◽  
Marcos V. Guterres ◽  
Omar P. Vilela Neto

ChemPhysChem ◽  
2021 ◽  
Hui Lv ◽  
Qian Li ◽  
Jiye Shi ◽  
Fei Wang ◽  
Chunhai Fan

Kimberly L. Berk ◽  
Steven M. Blum ◽  
Vanessa L. Funk ◽  
Yuhua Sun ◽  
In-Young Yang ◽  

2021 ◽  
Vol 16 (4) ◽  
pp. 612-623
Xiaoyu An ◽  
Zijie Meng ◽  
Yanfeng Wang ◽  
Junwei Sun

DNA molecular computing based on DNA strand displacement (DSD) technology is a potential computing model. Different functions can be realized by constructing DNA strand displacement analog circuit and analyzing its dynamic characteristics. In this paper, exploiting chemical reaction networks (CRNs) as the middle layer, a new chaotic oscillation circuit is constructed via DNA strand displacement and controlled by PID controller. The design of four-variable chaotic oscillatory circuit requires the combination and cascade by five DNA reaction modules. Based on the theory of stability and design principle of controller, the proportion terms, integration terms, and differentiation terms are added to chaotic oscillatory circuit for implementing PID controller. PID controller is implemented by five DNA reaction modules to stabilize the chaotic oscillation circuit. The validity of reaction modules circuit with their corresponding DSD reaction modules and controller is verified by visual DSD and Matlab. The PID controller may have better performance than PI controller, and it is an extension of PI controller.

2021 ◽  
Vol 120 (3) ◽  
pp. 220a
Alexander W. Cook ◽  
Bo Broadwater ◽  
Harold D. Kim

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