scholarly journals Survival, differentiation, and migration of high-purity mouse embryonic stem cell-derived progenitor motor neurons in fibrin scaffolds after sub-acute spinal cord injury

2014 ◽  
Vol 2 (11) ◽  
pp. 1672-1682 ◽  
Author(s):  
D. A. McCreedy ◽  
T. S. Wilems ◽  
H. Xu ◽  
J. C. Butts ◽  
C. R. Brown ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Cell Cultures ◽  
Motor Neurons ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cell ◽  
Cord Injury ◽  
And Migration ◽  
Tumorigenic Cell

Purification of stem cell cultures improves the interaction with tissue engineered fibrin scaffolds and reduces the potentially tumorigenic cell population.

Stem Cell Transplantation: A Promising Therapy for Spinal Cord Injury

2020 ◽  
Vol 15 (4) ◽  
pp. 321-331 ◽  
Author(s):  
Zhe Gong ◽  
Kaishun Xia ◽  
Ankai Xu ◽  
Chao Yu ◽  
Chenggui Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Therapeutic Potential ◽  
Embryonic Stem ◽  
Current Status ◽  
Cord Injury

Spinal Cord Injury (SCI) causes irreversible functional loss of the affected population. The incidence of SCI keeps increasing, resulting in huge burden on the society. The pathogenesis of SCI involves neuron death and exotic reaction, which could impede neuron regeneration. In clinic, the limited regenerative capacity of endogenous cells after SCI is a major problem. Recent studies have demonstrated that a variety of stem cells such as induced Pluripotent Stem Cells (iPSCs), Embryonic Stem Cells (ESCs), Mesenchymal Stem Cells (MSCs) and Neural Progenitor Cells (NPCs) /Neural Stem Cells (NSCs) have therapeutic potential for SCI. However, the efficacy and safety of these stem cellbased therapy for SCI remain controversial. In this review, we introduce the pathogenesis of SCI, summarize the current status of the application of these stem cells in SCI repair, and discuss possible mechanisms responsible for functional recovery of SCI after stem cell transplantation. Finally, we highlight several areas for further exploitation of stem cells as a promising regenerative therapy of SCI.

Transplantation of embryonic stem cell-derived neural stem cells for spinal cord injury in adult mice

2005 ◽  
Vol 27 (8) ◽  
pp. 812-819 ◽  
Author(s):  
Hajime Kimura ◽  
Masahide Yoshikawa ◽  
Ryousuke Matsuda ◽  
Hayato Toriumi ◽  
Fumihiko Nishimura ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Neural Stem Cells ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Adult Mice ◽  
Cord Injury

scholarly journals Rescuing macrophage normal function in spinal cord injury with embryonic stem cell conditioned media

2016 ◽  
Vol 9 (1) ◽  
Author(s):  
Lei Guo ◽  
Alyssa J. Rolfe ◽  
Xi Wang ◽  
Wenjiao Tai ◽  
Zhijian Cheng ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Normal Function ◽  
Conditioned Media ◽  
Cord Injury

scholarly journals Target Populations for First-In-Human Embryonic Stem Cell Research in Spinal Cord Injury

2011 ◽  
Vol 8 (5) ◽  
pp. 468-475 ◽  
Author(s):  
Frédéric Bretzner ◽  
Frédéric Gilbert ◽  
Françoise Baylis ◽  
Robert M. Brownstone
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Stem Cell Research ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Embryonic Stem Cell Research ◽  
Target Populations ◽  
Cord Injury
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