tumorigenic cell
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2021 ◽  
Vol 22 (16) ◽  
pp. 8704
Author(s):  
Alfonso Annunziata ◽  
Davide Liberti ◽  
Emiliano Bedini ◽  
Maria Elena Cucciolito ◽  
Domenico Loreto ◽  
...  

This article describes the synthesis, characterization, and biological activity of novel square-planar cationic platinum(II) complexes containing glucoconjugated triazole ligands and a comparison with the results obtained from the corresponding five-coordinate complexes bearing the same triazole ligands. Stability in solution, reactivity with DNA and small molecules of the new compounds were evaluated by NMR, fluorescence, and UV–vis absorption spectroscopy, together with their cytotoxic action against pairs of immortalized and tumorigenic cell lines. The results show that the square-planar species exhibit greater stability than the corresponding five-coordinate ones. Furthermore, although the square-planar complexes are less cytotoxic than the latter ones, they exhibit a certain selectivity. These results simultaneously demonstrate that overall stability is a fundamental prerequisite for preserving the performance of the agents and that coordinative saturation constitutes a point in favor of their biological action.



Life Sciences ◽  
2021 ◽  
pp. 119494
Author(s):  
Viatcheslav A. Mordvinov ◽  
Galina A. Minkova ◽  
Anna V. Kovner ◽  
Dmitriy V. Ponomarev ◽  
Maria N. Lvova ◽  
...  


2021 ◽  
Author(s):  
Yuhan Chang ◽  
Juan Zhang ◽  
Xinying Huo ◽  
Xinliang Qu ◽  
Chunlei Xia ◽  
...  


Author(s):  
Lisa G. Lanigan ◽  
Blake E. Hildreth ◽  
Wessel P. Dirksen ◽  
Jessica K. Simmons ◽  
Chelsea K. Martin ◽  
...  


2019 ◽  
Vol 47 (2) ◽  
pp. 921-934 ◽  
Author(s):  
Ilknur Sur-Erdem ◽  
Muhammed Sajid Hussain ◽  
Maria Asif ◽  
Nareg Pınarbası ◽  
Ali Cenk Aksu ◽  
...  


Metabolites ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 18 ◽  
Author(s):  
Daniela Rodrigues ◽  
Joana Pinto ◽  
Ana Araújo ◽  
Carmen Jerónimo ◽  
Rui Henrique ◽  
...  

Previous studies have shown that metabolomics can be a useful tool to better understand the mechanisms of carcinogenesis; however, alterations in biochemical pathways that lead to bladder cancer (BC) development have hitherto not been fully investigated. In this study, gas chromatography-mass spectrometry (GC-MS)-based metabolomics was applied to unveil the metabolic alterations between low-grade and high-grade BC cultured cell lines. Multivariable analysis revealed a panel of metabolites responsible for the separation between the two tumorigenic cell lines. Significantly lower levels of fatty acids, including myristic, palmitic, and palmitoleic acids, were found in high-grade versus low-grade BC cells. Furthermore, significantly altered levels of some amino acids were observed between low- and high-grade BC, namely glycine, leucine, methionine, valine, and aspartic acid. This study successfully demonstrated the potential of metabolomic analysis to discriminate BC cells according to tumor aggressiveness. Moreover, these findings suggest that bladder tumorigenic cell lines of different grades disclose distinct metabolic profiles, mainly affecting fatty acid biosynthesis and amino acid metabolism to compensate for higher energetic needs.



2019 ◽  
Vol 14 (1) ◽  
pp. 27
Author(s):  
MohammadAli Shokrgozar ◽  
Shahriyar Abdoli ◽  
Farzin Roohvand ◽  
Ladan Teimoori-Toolabi ◽  
Sara Shayan


2018 ◽  
Vol 1859 ◽  
pp. e110
Author(s):  
Valentina Giorgio ◽  
Victoria Burchell ◽  
Chiara Galber ◽  
Giulia Valente ◽  
Valeria Petronilli ◽  
...  


2016 ◽  
Vol 85 ◽  
pp. 488-495 ◽  
Author(s):  
Mahmood H. Akhtar ◽  
Tanveer A. Mir ◽  
N.G. Gurudatt ◽  
Saeromi Chung ◽  
Yoon-Bo Shim


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