A base-catalyzed cycloisomerization of 5-cyano-pentyne derivatives: an efficient synthesis of 3-cyano-4,5-dihydro-1H-pyrroles

2014 ◽  
Vol 50 (83) ◽  
pp. 12490-12492 ◽  
Author(s):  
Jia Meng ◽  
Yi-Jin Li ◽  
Yu-Long Zhao ◽  
Xiu-Bin Bu ◽  
Qun Liu
Keyword(s):  
Terminal Alkyne ◽  
Efficient Synthesis ◽  
Metal Free ◽  
Efficient Access

A base-catalyzed cycloisomerization of 5-cyano-pentyne bearing a terminal alkyne group has been developed under metal-free conditions. This reaction provides an efficient access to 3-cyano-4,5-dihydro-1H-pyrroles with 1,3-cyano migration as the key transformation.

Transition-Metal-Free, Intermolecular Azidoheteroarylation of Alkenes: Efficient Access to β-Azidoalkylated Quinoxalinones and Preliminary Antifungal Evaluation Against Magnaporthe grisea

Synthesis ◽  
2020 ◽  
Vol 52 (16) ◽  
pp. 2395-2409
Author(s):  
Weiwei Qin ◽  
Zhaodong Li ◽  
Yiming Du ◽  
Yue Chen ◽  
Yun-Lin Liu
Keyword(s):  
Transition Metal ◽  
Magnaporthe Grisea ◽  
Single Step ◽  
Domino Reaction ◽  
Efficient Synthesis ◽  
Metal Free ◽  
Efficient Access ◽  
First Time ◽  
Antibacterial Evaluation ◽  
Addition Pathway

An efficient, PhI(OAc)2-mediated, radical azidoheteroarylation of alkenes under transition-metal-free conditions is reported by employing TMSN3 and quinoxalin-2(1H)-ones as coupling partners. This domino reaction allows an efficient synthesis of valuable orangoazides containing quinoxalin-2(1H)-one derivatives and could be extended to phosphinyl-alkylated quinoxalin-2(1H)-one in a single step in moderate to excellent yields under mild conditions, as demonstrated by the preliminary antibacterial evaluation against Magnaporthe grisea for the first time. Mechanistic studies revealed that this transformation undergoes a cascade addition pathway controlled by a polar radical.

Metal-free oxidative cyclization of trifluoroacetimidohydrazides with methylhetarenes: a facile access to 3-hetaryl-5-trifluoromethyl-1,2,4-triazoles

2021 ◽  
Author(s):  
Xiao-Feng Wu ◽  
Zhengkai Chen ◽  
Jiajun Zhang ◽  
Tian-Hui Xu
Keyword(s):  
Oxidative Cyclization ◽  
Efficient Synthesis ◽  
Metal Free

A metal-free oxidative cyclization of trifluoroacetimidohydrazides with methylhetarenes for the efficient synthesis of 3-hetaryl-5-trifluoromethyl-1,2,4-triazoles has been developed. Notable features of this protocol include readily accessible starting materials, a broad substrate...

scholarly journals Metal-free porous phosphorus-doped g-C3N4 photocatalyst achieving efficient synthesis of benzoin

RSC Advances ◽  
2021 ◽  
Vol 11 (21) ◽  
pp. 12682-12686
Author(s):  
Yuanjin Li ◽  
Shuhui Wang ◽  
Jin Wu ◽  
Qiuyan Wang ◽  
Changqiu Ma ◽  
...  
Keyword(s):  
Benzyl Alcohol ◽  
Conversion Rate ◽  
Oxygen Activation ◽  
Superoxide Radicals ◽  
Efficient Synthesis ◽  
Metal Free ◽  
Phosphorus Doped

Porous phosphorus-doped g-C3N4 (PCNT) has intensive oxygen activation ability to generate superoxide radicals, and can efficiently catalyze synthesis of benzoin from benzyl alcohol, with conversion rate and selectivity near to 100%.

Cinchona alkaloid and di-tert-butyldicarbonate–DMAP promoted efficient synthesis of (E)-nitroolefins

RSC Advances ◽  
2016 ◽  
Vol 6 (59) ◽  
pp. 54495-54502 ◽  
Author(s):  
Nataraj Poomathi ◽  
Paramasivan T. Perumal
Keyword(s):  
Cinchona Alkaloid ◽  
Efficient Synthesis ◽  
Metal Free ◽  
High Yields

A simple and efficient metal-free methodology for the synthesis of β-nitroolefins has been developed from arylidinemalononitrile using bifunctional cinchona alkaloid along with di-tert-butyldicarbonate–DMAP in high yields with total selectivity.

Metal-free radical cascade dichloromethylation of activated alkenes using CH2Cl2: highly selective activation of the C–H bond

RSC Advances ◽  
2014 ◽  
Vol 4 (110) ◽  
pp. 64855-64859 ◽  
Author(s):  
Yunfei Tian ◽  
Zhong-Quan Liu
Keyword(s):  
Free Radical ◽  
Dicumyl Peroxide ◽  
Cascade Process ◽  
Selective Activation ◽  
Metal Free ◽  
Efficient Access ◽  
Radical Cascade

A dicumyl peroxide-initiated highly selective activation of the (sp3)C–H bond in dichloromethane (DCM, CH2Cl2) has been achieved, which allows efficient access to dichloronated oxindoles via a free-radical cascade process.

scholarly journals Decarboxylative Aromatization of b-Carbolines by Using Metal Free Catalysis and Efficient Synthesis of b-Carboline Derivatives

2015 ◽  
Vol 27 (12) ◽  
pp. 4701-4702
Author(s):  
Chunduru Srinivasa Rao ◽  
Ch. Venkata Ramana Reddy ◽  
B. Rama Devi ◽  
Jyothi Vantikommu ◽  
Jyotna Cherukuri ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Metal Free

Metal-free phenylpropiolate–azide polycycloaddition: efficient synthesis of functional poly(phenyltriazolylcarboxylate)s

2018 ◽  
Vol 9 (42) ◽  
pp. 5215-5223 ◽  
Author(s):  
Wei Yuan ◽  
Weiwen Chi ◽  
Ting Han ◽  
Jun Du ◽  
Hongkun Li ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Metal Free

Metal-free polycycloaddition of phenylpropiolates and azide is developed to afford multifunctional triazole-containing polyesters.

DDQ-mediated regioselective C–S bond formation: efficient access to allylic sulfides

2018 ◽  
Vol 5 (21) ◽  
pp. 3158-3162 ◽  
Author(s):  
Chunsheng Li ◽  
Jianxiao Li ◽  
Chaowei Tan ◽  
Wanqing Wu ◽  
Huanfeng Jiang
Keyword(s):  
Bond Formation ◽  
Metal Free ◽  
Efficient Access

A novel metal-free dehydrocoupling approach for constructing allylic sulfides via oxidative allylic C–H functionalization with high atom- and step-economy has been developed.

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