Cinchona alkaloid and di-tert-butyldicarbonate–DMAP promoted efficient synthesis of (E)-nitroolefins

A simple and efficient metal-free methodology for the synthesis of β-nitroolefins has been developed from arylidinemalononitrile using bifunctional cinchona alkaloid along with di-tert-butyldicarbonate–DMAP in high yields with total selectivity.

Download Full-text

Rapid and efficient synthesis of metal-free phthalocyanine derivatives

Journal of Porphyrins and Phthalocyanines ◽

10.1142/s1088424606000612 ◽

2006 ◽

Vol 10 (11) ◽

pp. 1253-1258 ◽

Cited By ~ 5

Author(s):

Ahmad Shaabani ◽

Ali Maleki

Keyword(s):

Ionic Liquid ◽

Microwave Irradiation ◽

Phase Transfer ◽

Tetrabutylammonium Bromide ◽

Efficient Synthesis ◽

Metal Free ◽

High Yields ◽

Short Times

Metal-free phthalocyanine derivatives have been synthesized in very short times with high yields in the presence of 1,1,3,3-tetramethylguanidinium trifluoroacetate (TMGT) as an ionic liquid or tetrabutylammonium bromide (TBAB) as a phase transfer reagent under both classical heating conditions and using microwave irradiation. The best results were obtained with ionic liquid. Both the ionic liquid and phase transfer reagent can be recycled for subsequent reactions and reused without appreciable loss of efficiency.

Download Full-text

An Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-ones by Using Recyclable Wang Resin Supported Sulfonic Acid Catalyst

Letters in Organic Chemistry ◽

10.2174/1570178617999201109203731 ◽

2020 ◽

Vol 17 ◽

Author(s):

Kalyani K. ◽

Srinivasa Reddy Kallam

Keyword(s):

Sulfonic Acid ◽

Functional Group ◽

Acid Catalyst ◽

Sulphonic Acid ◽

Isatoic Anhydride ◽

Efficient Synthesis ◽

Wang Resin ◽

Polymer Supported ◽

High Yields

Abstract:: An efficient synthesis of 2-substituted Quinazolin-4(3H)-ones has been developed from isatoic anhydride with various amidoximes by using recyclable polymer supported sulphonic acid catalyst. Excellent functional group compatibil-ity and high yields are the important features of this protocol.

Download Full-text

Metal-free oxidative cyclization of trifluoroacetimidohydrazides with methylhetarenes: a facile access to 3-hetaryl-5-trifluoromethyl-1,2,4-triazoles

Organic Chemistry Frontiers ◽

10.1039/d1qo00790d ◽

2021 ◽

Author(s):

Xiao-Feng Wu ◽

Zhengkai Chen ◽

Jiajun Zhang ◽

Tian-Hui Xu

Keyword(s):

Oxidative Cyclization ◽

Efficient Synthesis ◽

Metal Free

A metal-free oxidative cyclization of trifluoroacetimidohydrazides with methylhetarenes for the efficient synthesis of 3-hetaryl-5-trifluoromethyl-1,2,4-triazoles has been developed. Notable features of this protocol include readily accessible starting materials, a broad substrate...

Download Full-text

Metal-free porous phosphorus-doped g-C3N4 photocatalyst achieving efficient synthesis of benzoin

RSC Advances ◽

10.1039/d1ra00701g ◽

2021 ◽

Vol 11 (21) ◽

pp. 12682-12686

Author(s):

Yuanjin Li ◽

Shuhui Wang ◽

Jin Wu ◽

Qiuyan Wang ◽

Changqiu Ma ◽

...

Keyword(s):

Benzyl Alcohol ◽

Conversion Rate ◽

Oxygen Activation ◽

Superoxide Radicals ◽

Efficient Synthesis ◽

Metal Free ◽

Phosphorus Doped

Porous phosphorus-doped g-C3N4 (PCNT) has intensive oxygen activation ability to generate superoxide radicals, and can efficiently catalyze synthesis of benzoin from benzyl alcohol, with conversion rate and selectivity near to 100%.

Download Full-text

PEG-embedded KBr3: A recyclable catalyst for multicomponent coupling reaction for the efficient synthesis of functionalized piperidines

Beilstein Journal of Organic Chemistry ◽

10.3762/bjoc.7.157 ◽

2011 ◽

Vol 7 ◽

pp. 1334-1341 ◽

Cited By ~ 29

Author(s):

Sanny Verma ◽

Suman L Jain ◽

Bir Sain

Keyword(s):

Coupling Reaction ◽

Recyclable Catalyst ◽

Efficient Synthesis ◽

Molecular Bromine ◽

Keto Ester ◽

One Step ◽

High Yields ◽

Multicomponent Coupling ◽

Three Component Coupling

PEG-embedded potassium tribromide ([K+PEG]Br3 −) was found to be an efficient and recyclable catalyst for the synthesis of functionalized piperidines in high yields in a one step, three component coupling between aldehyde, amine and β-keto ester. At the end of the reaction the [K+PEG]Br3 − was readily regenerated from the reaction mixture by treating the residue containing [K+PEG]Br− with molecular bromine.

Download Full-text

Three-Component Synthesis of 4-Arylidene-3-alkylisoxazol-5(4H)-ones in the presence of potassium 2,5-dioxoimidazolidin-1-ide

Current Organic Chemistry ◽

10.2174/1385272825666210212120517 ◽

2021 ◽

Vol 25 ◽

Author(s):

Neda Reihani ◽

Hamzeh Kiyani

Keyword(s):

Ethylene Glycol ◽

Ethyl Acetoacetate ◽

Reaction Medium ◽

Hydroxylamine Hydrochloride ◽

Aromatic Aldehydes ◽

Catalyst Loading ◽

Efficient Synthesis ◽

Current Process ◽

High Yields ◽

Low Catalyst Loading

: An efficient synthesis of 4-arylidene-3-alkylisoxazole-5(4H)-ones has been implemented via the three-component cyclocondensation of aryl(heteroaryl)aldehydes with hydroxylamine hydrochloride and β-ketoesters. The potassium 2,5-dioxoimidazolidin-1-ide has been introduced as the new organocatalyst to facilitate of this heterocyclization. In the current process, three starting materials, including substituted benzaldehydes/heterocyclic aromatic aldehydes, hydroxylamine hydrochloride, and ethyl acetoacetate/propyl acetoacetate/butyryl acetoacetate have been successfully used for the synthesize of the number of substituted isoxazole-5(4H)-ones in good to high yields in ethylene glycol as a green reaction medium at 80 ºC. The low catalyst loading is also a main advantage over the some reported catalysts.

Download Full-text

A Simple and Efficient Synthesis of Highly Substituted Indeno[1,2-b]pyrrole and Acenaphtho[1,2-b]pyrrole Derivatives by Tandem Three-Component Reactions

Molecules ◽

10.3390/molecules23113031 ◽

2018 ◽

Vol 23 (11) ◽

pp. 3031 ◽

Cited By ~ 2

Author(s):

Xiaodong Tang ◽

Songlei Zhu ◽

Ying Ma ◽

Ren Wen ◽

Lanqi Cen ◽

...

Keyword(s):

Environmentally Benign ◽

Efficient Synthesis ◽

Reaction Conditions ◽

Dicarbonyl Compounds ◽

Pyrrole Derivatives ◽

Three Component Reaction ◽

High Yields ◽

Operational Simplicity

A green, convenient and tandem procedure for the efficient synthesis of highly substituted indeno[1,2-b]pyrrole and acenaphtho[1,2-b]pyrrole derivatives by domino three-component reaction of tryptamine/benzylamine, 1,3-dicarbonyl compounds and ninhydrin/ acenaphthenequinone is described. The significant features of this procedure were characterized by mild reaction conditions, high yields, operational simplicity and it being environmentally benign.

Download Full-text

Zn(L-proline)2: An efficient and reusable organocatalyst for the synthesis of polyfunctionally substituted pyrans and 2-amino-4-aryl-8-oxo-4,8-dihydropyrano[3,2-b]pyran derivatives

European Journal of Chemistry ◽

10.5155/eurjchem.10.2.166-170.1851 ◽

2019 ◽

Vol 10 (2) ◽

pp. 166-170 ◽

Cited By ~ 2

Author(s):

Fatma Ahmed Abo Elsoud ◽

Mohamed Abd-Elmonem ◽

Mohamed Abo Elsebaa ◽

Kamal Usef Sadek

Keyword(s):

Kojic Acid ◽

Aromatic Aldehydes ◽

Efficient Synthesis ◽

Atom Economy ◽

Short Reaction Time ◽

Biologically Relevant ◽

Three Component Reaction ◽

High Yields ◽

Organometallic Catalyst ◽

Work Up

Efficient synthesis of non-annulated 2-amino-4H-pyrans and 2-amino-8-oxo-4,8-dihydropyrano[3,2-b]pyran derivatives, which are biologically relevant heterocycles is achieved, utilizing a domino three-component reaction of ethyl acetoacetate or kojic acid with aromatic aldehydes and malononitrile catalyzed by Zn(L-proline)2 as reusable organometallic catalyst. The process exhibits high atom economy, short reaction time, simple work up, high yields and environmentally friendly nature. Excellent yields of the targeted molecules have been obtained.

Download Full-text