Cyclen-based cationic lipids containing a pH-sensitive moiety as gene delivery vectors

2015 ◽  
Vol 13 (2) ◽  
pp. 620-630 ◽  
Author(s):  
Zheng Huang ◽  
Yan-Hong Liu ◽  
Yi-Mei Zhang ◽  
Ji Zhang ◽  
Qiang Liu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Structure Activity Relationship ◽  
Ph Sensitive ◽  
Cationic Lipids ◽  
Activity Relationship ◽  
Structure Activity ◽  
Gene Delivery Vectors

Imidazole-functionalized cationic lipids with a cyclen headgroup were synthesized, and the structure–activity relationship in gene delivery mediated by these lipids was discussed.

scholarly journals Cationic lipids with a cyclen headgroup: synthesis and structure–activity relationship studies as non-viral gene vectors

RSC Advances ◽  
2017 ◽  
Vol 7 (30) ◽  
pp. 18681-18689 ◽  
Author(s):  
De-Chun Chang ◽  
Yi-Mei Zhang ◽  
Ji Zhang ◽  
Yan-Hong Liu ◽  
Xiao-Qi Yu
Keyword(s):  
Gene Delivery ◽  
Structure Activity Relationship ◽  
Cationic Lipids ◽  
Activity Relationship ◽  
Viral Gene ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Gene Delivery Vectors ◽  
Gene Vectors ◽  
Viral Gene Delivery

The structure–activity relationships of cyclen-based cationic lipids as non-viral gene delivery vectors were studied and clarified.

Structure–activity relationship studies of symmetrical cationic bolasomes as non-viral gene vectors

2016 ◽  
Vol 4 (33) ◽  
pp. 5575-5584 ◽  
Author(s):  
Zheng Huang ◽  
Yi-Mei Zhang ◽  
Qian Cheng ◽  
Ji Zhang ◽  
Yan-Hong Liu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Viral Gene ◽  
Structure Activity ◽  
Gene Delivery Vectors ◽  
Gene Vectors

Bolalipids based on lysine or cyclen headgroups were synthesized and their structure–activity relationship as gene delivery vectors was studied.

Cationic gemini lipids with cyclen headgroups: interaction with DNA and gene delivery abilities

RSC Advances ◽  
2014 ◽  
Vol 4 (83) ◽  
pp. 44261-44268 ◽  
Author(s):  
Yi-Mei Zhang ◽  
Yan-Hong Liu ◽  
Ji Zhang ◽  
Qiang Liu ◽  
Zheng Huang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Structure Activity Relationship ◽  
Cationic Lipids ◽  
Activity Relationship ◽  
Viral Gene ◽  
Structure Activity ◽  
Gene Vectors

Eleven Gemini cationic lipids and one mono counterpart were synthesized, and their structure–activity relationship as non-viral gene vectors was studied.

Cyclen-based cationic lipids with double hydrophobic tails for efficient gene delivery

2014 ◽  
Vol 2 (10) ◽  
pp. 1460-1470 ◽  
Author(s):  
Hai-Jiao Wang ◽  
Yan-Hong Liu ◽  
Ji Zhang ◽  
Yang Zhang ◽  
Yan Xia ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Gene Transfection ◽  
Structure Activity Relationship ◽  
Cationic Lipids ◽  
Activity Relationship ◽  
Structure Activity ◽  
Efficient Gene ◽  
Relationship Of

The gene transfection abilities and structure–activity relationship of newly designed cationic lipids were studied in detail.

Structure–activity relationship of novel low-generation dendrimers for gene delivery

2018 ◽  
Vol 16 (42) ◽  
pp. 7833-7842 ◽  
Author(s):  
Yong-Guang Gao ◽  
Xiao Lin ◽  
Kai Dang ◽  
Shan-Feng Jiang ◽  
Ye Tian ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Sar Studies ◽  
Structure Activity ◽  
Gene Vectors ◽  
Relationship Of

Structure–activity relationship (SAR) studies are very critical to design ideal gene vectors for gene delivery.

Synthesis, Activity, and Structure−Activity Relationship Studies of Novel Cationic Lipids for DNA Transfer

1998 ◽  
Vol 41 (2) ◽  
pp. 224-235 ◽  
Author(s):  
Gerardo Byk ◽  
Catherine Dubertret ◽  
Virginie Escriou ◽  
Marc Frederic ◽  
Gabrielle Jaslin ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Cationic Lipids ◽  
Dna Transfer ◽  
Activity Relationship ◽  
Structure Activity ◽  
Synthesis Activity

Hydroxyl-containing non-viral lipidic gene vectors with macrocyclic polyamine headgroups

RSC Advances ◽  
2015 ◽  
Vol 5 (73) ◽  
pp. 59417-59427 ◽  
Author(s):  
Hai-Jiao Wang ◽  
Xi He ◽  
Yang Zhang ◽  
Ji Zhang ◽  
Yan-Hong Liu ◽  
...  
Keyword(s):  
Gene Transfection ◽  
Structure Activity Relationship ◽  
Cationic Lipids ◽  
Activity Relationship ◽  
Macrocyclic Polyamine ◽  
Structure Activity ◽  
Gene Vectors ◽  
Relationship Of

The gene transfection abilities and structure–activity relationship of the newly designed hydroxyl-containing cationic lipids were studied in detail.

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