Hydroxyl-containing non-viral lipidic gene vectors with macrocyclic polyamine headgroups

RSC Advances ◽  
2015 ◽  
Vol 5 (73) ◽  
pp. 59417-59427 ◽  
Author(s):  
Hai-Jiao Wang ◽  
Xi He ◽  
Yang Zhang ◽  
Ji Zhang ◽  
Yan-Hong Liu ◽  
...  

The gene transfection abilities and structure–activity relationship of the newly designed hydroxyl-containing cationic lipids were studied in detail.

2014 ◽  
Vol 2 (10) ◽  
pp. 1460-1470 ◽  
Author(s):  
Hai-Jiao Wang ◽  
Yan-Hong Liu ◽  
Ji Zhang ◽  
Yang Zhang ◽  
Yan Xia ◽  
...  

The gene transfection abilities and structure–activity relationship of newly designed cationic lipids were studied in detail.


RSC Advances ◽  
2017 ◽  
Vol 7 (30) ◽  
pp. 18681-18689 ◽  
Author(s):  
De-Chun Chang ◽  
Yi-Mei Zhang ◽  
Ji Zhang ◽  
Yan-Hong Liu ◽  
Xiao-Qi Yu

The structure–activity relationships of cyclen-based cationic lipids as non-viral gene delivery vectors were studied and clarified.


2018 ◽  
Vol 16 (42) ◽  
pp. 7833-7842 ◽  
Author(s):  
Yong-Guang Gao ◽  
Xiao Lin ◽  
Kai Dang ◽  
Shan-Feng Jiang ◽  
Ye Tian ◽  
...  

Structure–activity relationship (SAR) studies are very critical to design ideal gene vectors for gene delivery.


RSC Advances ◽  
2014 ◽  
Vol 4 (83) ◽  
pp. 44261-44268 ◽  
Author(s):  
Yi-Mei Zhang ◽  
Yan-Hong Liu ◽  
Ji Zhang ◽  
Qiang Liu ◽  
Zheng Huang ◽  
...  

Eleven Gemini cationic lipids and one mono counterpart were synthesized, and their structure–activity relationship as non-viral gene vectors was studied.


Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
MA Brenzan ◽  
CV Nakamura ◽  
BPD Filho ◽  
T Ueda-Nakamura ◽  
MCM Young ◽  
...  

2019 ◽  
Vol 23 (5) ◽  
pp. 503-516 ◽  
Author(s):  
Qiang Zhang ◽  
Xude Wang ◽  
Liyan Lv ◽  
Guangyue Su ◽  
Yuqing Zhao

Dammarane-type ginsenosides are a class of tetracyclic triterpenoids with the same dammarane skeleton. These compounds have a wide range of pharmaceutical applications for neoplasms, diabetes mellitus and other metabolic syndromes, hyperlipidemia, cardiovascular and cerebrovascular diseases, aging, neurodegenerative disease, bone disease, liver disease, kidney disease, gastrointestinal disease and other conditions. In order to develop new antineoplastic drugs, it is necessary to improve the bioactivity, solubility and bioavailability, and illuminate the mechanism of action of these compounds. A large number of ginsenosides and their derivatives have been separated from certain herbs or synthesized, and tested in various experiments, such as anti-proliferation, induction of apoptosis, cell cycle arrest and cancer-involved signaling pathways. In this review, we have summarized the progress in structural modification, shed light on the structure-activity relationship (SAR), and offered insights into biosynthesis-structural association. This review is expected to provide a preliminary guide for the modification and synthesis of ginsenosides.


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