Highly efficient synthesis of novel methyl 132-methylene mesopyropheophorbide a and its stereoselective Michael addition reaction

2015 ◽  
Vol 13 (7) ◽  
pp. 1992-1995 ◽  
Author(s):  
Jiazhu Li ◽  
Yang Liu ◽  
Xi-Sen Xu ◽  
Yan-Long Li ◽  
Shan-Guo Zhang ◽  
...  
Keyword(s):  
Michael Addition ◽  
Michael Reaction ◽  
Addition Reaction ◽  
Efficient Synthesis ◽  
Michael Addition Reaction ◽  
Highly Efficient ◽  
Ph Dependent

pH-Dependent regioselective condensation of methyl mesopyropheophorbide a with HCHO is studied and stereoselective Michael reaction of the 132-methylene product is also discussed.

KF/Al2O3as a Highly Efficient, Green, Heterogeneous, and Reusable Catalytic System for the Solvent-Free Synthesis of Carboacyclic Nucleosides via Michael Addition Reaction

2008 ◽  
Vol 39 (1) ◽  
pp. 139-157 ◽  
Author(s):  
Abdolkarim Zare ◽  
Alireza Hasaninejad ◽  
Mohammad Hassan Beyzavi ◽  
Ahmad Reza Moosavi Zare ◽  
Ali Khalafi-Nezhad ◽  
...  
Keyword(s):  
Catalytic System ◽  
Michael Addition ◽  
Addition Reaction ◽  
Solvent Free ◽  
Michael Addition Reaction ◽  
Highly Efficient ◽  
Solvent Free Synthesis

Efficient Synthesis of 3-Amino-1,5-benzodiazepine-2-one Derivatives

Synlett ◽  
2017 ◽  
Vol 28 (10) ◽  
pp. 1183-1186 ◽  
Author(s):  
Nobuhiro Obara ◽  
Takeshi Watanabe ◽  
Tomohiro Asakawa ◽  
Toshiyuki Kan ◽  
Takao Tanaka
Keyword(s):  
Michael Addition ◽  
Convenient Method ◽  
Addition Reaction ◽  
Efficient Synthesis ◽  
Michael Addition Reaction ◽  
One Pot ◽  
Simple Method ◽  
The Michael Addition

A convenient method for synthesizing 3-amino-1,5-benzodiazepine-2-one via the Michael addition reaction of o-phenylenediamine with dehydroalanine ester derivatives, followed by cyclization, was developed. This simple method was used to obtain a variety of N-substituted 3-amino-1,5-benzodiazepine-2-ones in one pot with good yields.

Direct organocatalytic asymmetric Michael reaction of fluorine hemiaminal-type nucleophile to 4-nitro-5-styrylisoxazoles

2020 ◽  
Vol 7 (11) ◽  
pp. 1343-1348
Author(s):  
Luyao Li ◽  
Bo Zhu ◽  
Huihui Fan ◽  
Zhiyong Jiang ◽  
Junbiao Chang
Keyword(s):  
Michael Addition ◽  
Michael Reaction ◽  
Addition Reaction ◽  
Michael Addition Reaction ◽  
Asymmetric Michael Addition ◽  
Asymmetric Michael Reaction ◽  
First Time

Herein, we report a chiral bifunctional thiourea catalyzed asymmetric Michael addition reaction between 2-(trifluoromethyl)oxazol-5(2H)-one as a direct C-2-position nucleophile to 4-nitro-5-styrylisoxazoles for the first time.

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