Direct catalytic synthesis of densely substituted 3-formylpyrroles from imines and 1,4-ketoaldehydes

RSC Advances ◽  
2014 ◽  
Vol 4 (65) ◽  
pp. 34548-34551 ◽  
Author(s):  
Indresh Kumar ◽  
Nisar A. Mir ◽  
Panduga Ramaraju ◽  
Deepika Singh ◽  
Vivek K. Gupta ◽  
...  
Keyword(s):  
Room Temperature ◽  
Catalytic Synthesis ◽  
Mild Conditions ◽  
High Yields

An organocatalytic formal [3 + 2] cycloaddition have been developed between 1,4-ketoaldehydes and imines to synthesize densely substituted 3-formylpyrroles in high yields (up to 70%) under mild conditions at room temperature.

Direct catalytic synthesis of β-(C3)-substituted pyrroles: a complementary addition to the Paal–Knorr reaction

2021 ◽  
Vol 57 (2) ◽  
pp. 251-254
Author(s):  
Amol Prakash Pawar ◽  
Jyothi Yadav ◽  
Nisar Ahmad Mir ◽  
Eldhose Iype ◽  
Krishnan Rangan ◽  
...  
Keyword(s):  
Dft Calculations ◽  
Catalytic Synthesis ◽  
Primary Amines ◽  
Multicomponent Synthesis ◽  
Mild Conditions ◽  
Substituted Pyrroles ◽  
High Yields

Direct catalytic multicomponent synthesis of β-(C3)-substituted pyrroles is developed with good to high yields, using aqueous succinaldehyde, primary amines, and isatins under mild conditions. An access to the β-substituted free NH-pyrrole is the main focus of the work along with DFT-calculations.

scholarly journals An Efficient Protocol for the Synthesis of Quinoxaline Derivatives at Room Temperature Using Recyclable Alumina-Supported Heteropolyoxometalates

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Diego M. Ruiz ◽  
Juan C. Autino ◽  
Nancy Quaranta ◽  
Patricia G. Vázquez ◽  
Gustavo P. Romanelli
Keyword(s):  
Room Temperature ◽  
Incipient Wetness Impregnation ◽  
Reaction Conditions ◽  
Commercial Alumina ◽  
Mild Conditions ◽  
Quinoxaline Derivatives ◽  
Incipient Wetness ◽  
High Yields ◽  
Catalytic Test

We report a suitable quinoxaline synthesis using molybdophosphovanadates supported on commercial alumina cylinders as catalysts. These catalysts were prepared by incipient wetness impregnation. The catalytic test was performed under different reaction conditions in order to know the performance of the synthesized catalysts. The method shows high yields of quinoxaline derivatives under heterogeneous conditions. Quinoxaline formation was obtained using benzyl,o-phenylenediamine, and toluene as reaction solvent at room temperature. The CuH2PMo11VO40supported on alumina showed higher activity in the tested reaction. Finally, various quinoxalines were prepared under mild conditions and with excellent yields.

Michael Addition of Aryl Thiols to 3-(2,2,2-Trifluoroethylidene)Oxindoles under Catalyst-Free Conditions: The Rapid Synthesis of Sulfur-Containing Oxindole Derivatives

2018 ◽  
Vol 42 (4) ◽  
pp. 210-214
Author(s):  
Bo Chen ◽  
Jiaheng Lei ◽  
Junling Zhao
Keyword(s):  
Michael Addition ◽  
Room Temperature ◽  
Rapid Synthesis ◽  
Efficient Catalyst ◽  
Mild Conditions ◽  
Catalyst Free ◽  
Wide Range ◽  
High Yields ◽  
The Michael Addition ◽  
Sulfur Containing

A mild and efficient catalyst-free method for the rapid synthesis at room temperature of 3-thiomethylated oxindole derivatives has been achieved via the Michael addition of aryl thiols to ring and 1-substituted 3-(2,2,2-trifluoroethylidene)oxindoles in dichloromethane. The method was applicable to a wide range of thiols and variously substituted 3-(2,2,2-trifluoroethylidene)oxindoles under mild conditions as demonstrated by the synthesis in high yields with good diastereoselectivities of 30 3-thiomethylated oxindoles bearing a trifluoromethyl group.

Catalytic system for pyridine oxidation to N-oxides under mild conditions based on polyoxomolybdate

RSC Advances ◽  
2015 ◽  
Vol 5 (46) ◽  
pp. 36809-36812 ◽  
Author(s):  
Chunxia Yang ◽  
Wei Zhao ◽  
Zhiguo Cheng ◽  
Baomin Luo ◽  
Dongqin Bi
Keyword(s):  
Catalytic System ◽  
Room Temperature ◽  
Mild Conditions ◽  
High Yields

A reusable and effective catalytic system has been developed for oxidation of pyridines catalyzed by Keplerate polyoxomolybdate ({Mo132}) at room temperature. Pyridine compounds could be oxidized in high yields under mild conditions.

scholarly journals SbCl3-Catalyzed conversion of ketones and aldehydes into gem-dihydroperoxides (DHPs) with 30% H2O2

2015 ◽  
Vol 11 (5) ◽  
pp. 3547-3553 ◽  
Author(s):  
Davood Azarifar ◽  
Boshra Mahmoudi ◽  
Kaveh Khosravi
Keyword(s):  
Present Method ◽  
Room Temperature ◽  
Reaction Times ◽  
Experimental Procedure ◽  
Mild Conditions ◽  
Efficient Conversion ◽  
High Yields ◽  
Catalyzed Oxidation

A simple and efficient conversion of ketones and aldehydes into corresponding gem-dihydroperoxides (DHPs) has been developed by SbCl3-catalyzed oxidation with 30% H2O2 at room temperature. The reactions proceeded smoothly under mild conditions at room temperature. Simple experimental procedure, use of inexpensive and non-toxic catalyst, high yields and low reaction times are the main merits of the present method.

Novel cyclization and reductive coupling of bicyclic olefins with alkyl propiolates catalyzed by nickel complexes

2002 ◽  
Vol 74 (1) ◽  
pp. 69-75 ◽  
Author(s):  
Dinesh Kumar Rayabarapu ◽  
Chien-Hong Cheng
Keyword(s):  
Nickel Complex ◽  
Room Temperature ◽  
Nickel Complexes ◽  
Coupling Reaction ◽  
Coupling Reactions ◽  
Reductive Coupling ◽  
Mild Conditions ◽  
Reaction Proceeds ◽  
High Yields ◽  
Alkyl Propiolates

In this article, new metal-mediated cyclization and reductive coupling reactions of bicyclic olefins with alkynes are described. Oxabicyclic alkenes undergo cyclization with alkyl propiolates at 80 C catalyzed by nickel complexes to give benzocoumarin derivatives in high yields. The reaction of bicyclic alkenes (oxa- and azacyclic alkenes) with alkyl propiolates at room temperature in the presence of the same nickel complex gave 1,2-dihydro-napthelene derivatives in good-to-excellent yields. This reductive coupling reaction proceeds under very mild conditions in complete regio- and stereoselective fashion. A mechanism to account for the coumarin formation and the reductive coupling is proposed.

scholarly journals An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2501 ◽  
Author(s):  
Tarek S. Ibrahim ◽  
Israa A. Seliem ◽  
Siva S. Panda ◽  
Amany M. M. Al-Mahmoudy ◽  
Zakaria K. M. Abdel-Samii ◽  
...  
Keyword(s):  
Amino Acid ◽  
Reaction Time ◽  
Microwave Irradiation ◽  
Room Temperature ◽  
Efficient Synthesis ◽  
Short Reaction Time ◽  
Mild Conditions ◽  
Drug Conjugates ◽  
Cost Efficient ◽  
High Yields

A straightforward, mild and cost-efficient synthesis of various arylamides in water was accomplished using versatile benzotriazole chemistry. Acylation of various amines was achieved in water at room temperature as well as under microwave irradiation. The developed protocol unfolds the synthesis of amino acid aryl amides, drug conjugates and benzimidazoles. The environmentally friendly synthesis, short reaction time, simple workup, high yields, mild conditions and free of racemization are the key advantages of this protocol.

scholarly journals Chemoselective aza-Michael addition of indoles to 2-aroyl-1,3-diarylenones

2019 ◽  
Vol 44 (1-2) ◽  
pp. 97-103
Author(s):  
Zheng Li ◽  
Aizhen Yang ◽  
Xiaolong Ma ◽  
Zhenrong Liu
Keyword(s):  
Transition Metal ◽  
Michael Addition ◽  
Potassium Hydroxide ◽  
Room Temperature ◽  
Transition Metal Catalysts ◽  
Atom Economy ◽  
Mild Conditions ◽  
High Yields ◽  
Work Up ◽  
Aryl Methyl

A total of 20 examples of 2-[(1 H-indol-1-yl)(aryl)methyl]-1,3-diphenylpropane-1,3-diones were efficiently synthesized by the aza-Michael addition at the N1 position of indoles with 2-aroyl-1,3-diarylenones at room temperature in the presence of potassium hydroxide. The salient features of this protocol are no transition-metal catalysts, mild conditions, high chemoselectivity, high atom economy, high yields, and a simple work-up procedure.

Construction of Esters through Sulfuryl Fluoride (SO2F2) Mediated Dehydrative Coupling of Carboxylic Acids with Alcohols at Room Temperature

Synthesis ◽  
2019 ◽  
Vol 51 (20) ◽  
pp. 3901-3907 ◽  
Author(s):  
Shi-Meng Wang ◽  
Njud S. Alharbi ◽  
Hua-Li Qin
Keyword(s):  
Carboxylic Acids ◽  
Room Temperature ◽  
Functional Group ◽  
High Efficiency ◽  
Sulfuryl Fluoride ◽  
Mild Conditions ◽  
High Yields

A facile method for the construction of esters through dehydrative coupling of carboxylic acids with alcohols is developed. The reactions are mediated by sulfuryl fluoride (SO2F2) at room temperature and proceed with high efficiency. The method has several advantages including broad substrate scope, mild conditions, excellent functional group compatibility and affords high yields, even on gram scale.

SuFEx Activation with Ca(NTf2)2: A Unified Strategy to Access Sulfamides, Sulfamates and Sulfonamides from S(VI) Fluorides

2020 ◽  
Author(s):  
Subham Mahapatra ◽  
Cristian P. Woroch ◽  
Todd W. Butler ◽  
Sabrina N. Carneiro ◽  
Sabrina C. Kwan ◽  
...  
Keyword(s):  
Room Temperature ◽  
Medicinal Chemistry ◽  
Mild Conditions ◽  
Broad Array

<p><br></p> <p>A method to activate sulfamoyl fluorides, fluorosulfates, and sulfonyl fluorides with calcium triflimide, and DABCO for SuFEx with amines is described. The reaction was applied to a diverse set of sulfamides, sulfamates, and sulfonamides at room temperature under mild conditions. Additionally, we highlight the application of this transformation to parallel medicinal chemistry to generate a broad array of nitrogen-based S(VI) compounds. </p>

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