Structure and biological activity of a conformational constrained apolipoprotein A-I-derived helical peptide targeting the protein haptoglobin

RSC Advances ◽  
2014 ◽  
Vol 4 (93) ◽  
pp. 51353-51361 ◽  
Author(s):  
Luisa Cigliano ◽  
Lucia De Rosa ◽  
Donatella Diana ◽  
Rossella Di Stasi ◽  
Maria Stefania Spagnuolo ◽  
...  
Keyword(s):  
Biological Activity ◽  
Apolipoprotein A ◽  
Helical Peptide ◽  
Peptide Targeting

Effect of amino acid distribution of amphipathic helical peptide derived from human apolipoprotein A-I on membrane curvature sensing

FEBS Letters ◽  
2013 ◽  
Vol 587 (5) ◽  
pp. 510-515 ◽  
Author(s):  
Masafumi Tanaka ◽  
Yuki Takamura ◽  
Toru Kawakami ◽  
Saburo Aimoto ◽  
Hiroyuki Saito ◽  
...  
Keyword(s):  
Amino Acid ◽  
Membrane Curvature ◽  
Amino Acid Distribution ◽  
Curvature Sensing ◽  
Human Apolipoprotein ◽  
Apolipoprotein A ◽  
Helical Peptide

W12-P-055 Amphipathic α-helical peptide models of apolipoprotein A-I inhibit LDL oxidation and inactivation of PAF-acetyl-hydrolase in vitro

2005 ◽  
Vol 6 (1) ◽  
pp. 75
Author(s):  
M. Petraki ◽  
C.H. Alexopoulos ◽  
C. Sakarellos ◽  
M. Sakarellos-Daitsiotis ◽  
A.D. Tselepis
Keyword(s):  
Ldl Oxidation ◽  
Apolipoprotein A ◽  
Helical Peptide ◽  
Peptide Models

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

Effects of Vincristine on Endothelial Microtubules in the Spinal Cord

1976 ◽  
Vol 34 ◽  
pp. 58-59
Author(s):  
John L. Beggs ◽  
John D. Waggener ◽  
Wanda Miller
Keyword(s):  
Spinal Cord ◽  
Biological Activity ◽  
Horseradish Peroxidase ◽  
Transport Mechanism ◽  
Vasogenic Edema ◽  
Vesicular Transport ◽  
Close Proximity

Microtubules (MT) are versatile organelles participating in a wide variety of biological activity. MT involvement in the movement and transport of cytoplasmic components has been well documented. In the course of our study on trauma-induced vasogenic edema in the spinal cord we have concluded that endothelial vesicles contribute to the edema process. Using horseradish peroxidase as a vascular tracer, labeled endothelial vesicles were present in all situations expected if a vesicular transport mechanism was in operation. Frequently,labeled vesicles coalesced to form channels that appeared to traverse the endothelium. The presence of MT in close proximity to labeled vesicles sugg ested that MT may play a role in vesicular activity.

Regulation of intestinal apolipoprotein A-IV synthesis

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S270-S274
Author(s):  
P TSO ◽  
L YAO ◽  
S ZHENG ◽  
L EE
Keyword(s):  
Apolipoprotein A

Isothiazol-3(2 H )-ones, Part I: Synthesis, Reactions and Biological Activity

2002 ◽  
Vol 23 (1) ◽  
pp. 79-121 ◽  
Author(s):  
Kathleen Taubert ◽  
Susanne Kraus ◽  
Bärbel Schulze
Keyword(s):  
Biological Activity ◽  
Synthesis Reactions

Lp(a): der akzeptierte unabhängige Risikofaktor

2019 ◽  
Vol 23 (09) ◽  
pp. 388-391
Author(s):  
Volker Schettler
Keyword(s):  
Lipoprotein A ◽  
Apolipoprotein A ◽  
Apolipoprotein B100

Lipoprotein(a) (Lp(a)) besteht aus einem LDL-Partikel, an dem über das Apolipoprotein B100 des Partikels eine Disulfidbrücke zu einem Apolipoprotein(a) besteht ( Abb. 1 ). Obwohl Lp(a) bereits 1963 von Berg et al. erstmals als „lipoprotein associated antigen“ entdeckt 1 und schon früh ein Zusammenhang mit kardiovaskulären Ereignissen diskutiert wurde 2, konnten diese Annahmen der klinischen Eigenschaften erst deutlich später im Rahmen von epidemiologischen Evaluationen bestätigt werden 3, 4. Ab einer Lp(a)-Konzentration von über 30 mg/dl (> 75 nmol/l) besteht ein nahezu linearer Zusammenhang zwischen dem Anstieg der Lp(a)-Konzentration und kardiovaskulären Ereignissen wie Myokardinfarkt und das Risiko für eine Aortenklappenstenose 3, 4.

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