Exploitation of stem-loop DNA as a dual-input gene sensing platform: extension to subtyping of influenza A viruses

2014 ◽  
Vol 5 (10) ◽  
pp. 4082 ◽  
Author(s):  
Yu-Hsuan Lai ◽  
Chang-Chun Lee ◽  
Chwan-Chuen King ◽  
Min-Chieh Chuang ◽  
Ja-an Annie Ho
Keyword(s):  
Influenza A ◽  
Influenza A Viruses ◽  
Stem Loop ◽  
Input Gene ◽  
Sensing Platform

TMPRSS2 is essential for pathogenicity of H7N9 and H1N1 influenza A viruses in mice

Pneumologie ◽  
2014 ◽  
Vol 68 (02) ◽  
Author(s):  
C Tarnow ◽  
G Engels ◽  
A Arendt ◽  
F Schwalm ◽  
H Sediri ◽  
...  
Keyword(s):  
Influenza A ◽  
H1n1 Influenza ◽  
Influenza A Viruses

Killing two birds with one stone – Prenylated flavonoids disrupt the lethal synergism of influenza A viruses and pneumococci

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
U Grienke ◽  
M Richter ◽  
E Walther ◽  
A Hoffmann ◽  
J Kirchmair ◽  
...  
Keyword(s):  
Influenza A ◽  
Influenza A Viruses ◽  
Prenylated Flavonoids

Occurrence of temperature-sensitive influenza A viruses in nature.

1982 ◽  
Vol 41 (2) ◽  
pp. 353-359 ◽  
Author(s):  
C M Chu ◽  
S F Tian ◽  
G F Ren ◽  
Y M Zhang ◽  
L X Zhang ◽  
...  
Keyword(s):  
Influenza A ◽  
Temperature Sensitive ◽  
Influenza A Viruses

Heterogeneity of the mutation rates of influenza A viruses: isolation of mutator mutants.

1992 ◽  
Vol 66 (4) ◽  
pp. 2491-2494 ◽  
Author(s):  
P Suárez ◽  
J Valcárcel ◽  
J Ortín
Keyword(s):  
Influenza A ◽  
Mutation Rates ◽  
Influenza A Viruses

Pathogenesis of H7 Influenza A Viruses Isolated from Ostriches in the Homologous Host Infected Experimentally

2003 ◽  
Vol 47 (s3) ◽  
pp. 1150-1153 ◽  
Author(s):  
R. J. Manvell ◽  
C. English ◽  
P. H. Jorgensen ◽  
I. H. Brown
Keyword(s):  
Influenza A ◽  
Influenza A Viruses

scholarly journals An evaluation of the InDevR FluChip-8G insight microarray assay in characterizing influenza a viruses

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Emily S. Bailey ◽  
Xinye Wang ◽  
Mai-juan Ma ◽  
Guo-lin Wang ◽  
Gregory C. Gray
Keyword(s):  
Influenza A ◽  
Influenza Viruses ◽  
Time Range ◽  
Influenza B ◽  
Influenza A Viruses ◽  
Laboratory Methods ◽  
Duke University ◽  
Multiple Viral Strains ◽  
Rapid Characterization

AbstractInfluenza viruses are an important cause of disease in both humans and animals, and their detection and characterization can take weeks. In this study, we sought to compare classical virology techniques with a new rapid microarray method for the detection and characterization of a very diverse, panel of animal, environmental, and human clinical or field specimens that were molecularly positive for influenza A alone (n = 111), influenza B alone (n = 3), both viruses (n = 13), or influenza negative (n = 2) viruses. All influenza virus positive samples in this study were first subtyped by traditional laboratory methods, and later evaluated using the FluChip-8G Insight Assay (InDevR Inc. Boulder, CO) in laboratories at Duke University (USA) or at Duke Kunshan University (China). The FluChip-8G Insight multiplexed assay agreed with classical virologic techniques 59 (54.1%) of 109 influenza A-positive, 3 (100%) of the 3 influenza B-positive, 0 (0%) of 10 both influenza A- and B-positive samples, 75% of 24 environmental samples including those positive for H1, H3, H7, H9, N1, and N9 strains, and 80% of 22 avian influenza samples. It had difficulty with avian N6 types and swine H3 and N2 influenza specimens. The FluChip-8G Insight assay performed well with most human, environmental, and animal samples, but had some difficulty with samples containing multiple viral strains and with specific animal influenza strains. As classical virology methods are often iterative and can take weeks, the FluChip-8G Insight Assay rapid results (time range 8 to 12 h) offers considerable time savings. As the FluChip-8G analysis algorithm is expected to improve over time with addition of new subtypes and sample matrices, the FluChip-8G Insight Assay has considerable promise for rapid characterization of novel influenza viruses affecting humans or animals.

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