Obtaining complementary polypeptide sequence information from a single precursor ion packet via sequential ion mobility-resolved electron transfer and vibrational activation

The Analyst ◽  
2015 ◽  
Vol 140 (21) ◽  
pp. 7175-7183 ◽  
Author(s):  
Deepali Rathore ◽  
Forouzan Aboufazeli ◽  
Eric D. Dodds
Keyword(s):  
Electron Transfer ◽  
Ion Mobility ◽  
Electron Transfer Dissociation ◽  
Collision Induced Dissociation ◽  
Sequence Information ◽  
Polypeptide Sequence ◽  
Single Precursor

Electron transfer, ion mobility, and vibrational activation are combined to obtain temporally-resolved electron transfer dissociation and collision-induced dissociation spectra from a single packet of protonated polypeptide ions.

scholarly journals Ion mobility-resolved collision-induced dissociation and electron transfer dissociation of N-glycopeptides: gathering orthogonal connectivity information from a single mass-selected precursor ion population

The Analyst ◽  
2017 ◽  
Vol 142 (24) ◽  
pp. 4691-4702 ◽  
Author(s):  
Venkata Kolli ◽  
Katherine N. Schumacher ◽  
Eric D. Dodds
Keyword(s):  
Electron Transfer ◽  
Ion Mobility ◽  
Electron Transfer Dissociation ◽  
Collision Induced Dissociation ◽  
Connectivity Information ◽  
Single Mass

One packet of N-glycopeptide precursors can be successively probed by CID and ETD, with fragmentation spectra deconvoluted via IM.

Improving the Identification Rate of Endogenous Peptides Using Electron Transfer Dissociation and Collision-Induced Dissociation

2013 ◽  
Vol 12 (12) ◽  
pp. 5410-5421 ◽  
Author(s):  
Eisuke Hayakawa ◽  
Gerben Menschaert ◽  
Pieter-Jan De Bock ◽  
Walter Luyten ◽  
Kris Gevaert ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Electron Transfer Dissociation ◽  
Collision Induced Dissociation ◽  
Identification Rate ◽  
Endogenous Peptides
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