Mirian Farinon
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Priscila Schmidt Lora
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Leandro Nicolodi Francescato
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Valquiria Linck Bassani
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AmÉlia Teresinha Henriques
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Equisetum giganteum is a plant used in traditional medicine as diuretic. From our knowledge this is the first
time this plant is tested in an in vivo model of acute inflammation. To evaluate the effect of aqueous extract of giant
horsetail (AEGH) as immunomodulatory therapy, antigen-induced arthritis (AIA) was generated in mice with methylated
bovine serum albumin (mBSA). Inflammation was evaluated by articular nociception, leukocytes migration and
lymphocyte proliferation. AEGH reduced nociception at 3, 6 and 24 h (P < 0.01), decreased leukocyte migration (P <
0.015), and inhibited lymphocyte proliferation stimulated with Concanavalin A and Lipopolysaccharide (P < 0.05). In
conclusion, AEGH has an anti-inflammatory potential in acute model of inflammation, as well as immunomodulatory
effect on both B and T lymphocytes, with an action independent of cytotoxicity.