Simultaneous determination of ivabradine, metoprolol and their metabolites in rat plasma by ultra-performance liquid chromatography tandem mass spectrometry and its application in a pharmacokinetic study

2015 ◽  
Vol 7 (19) ◽  
pp. 8459-8465 ◽  
Author(s):  
Wei Sun ◽  
Ruimin Chen ◽  
Wanshu Li ◽  
Hui Zhang ◽  
Jifeng Ye ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Pharmacokinetic Study ◽  
Ultra Performance Liquid Chromatography ◽  
Rat Plasma ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

A sensitive and rapid UPLC-MS/MS method was developed to determine ivabradine, metoprolol and their corresponding metabolites in rat plasma simultaneously.

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