A computational study of the effect of the metal organic framework environment on the release of chemically stored nitric oxide

2015 ◽  
Vol 17 (36) ◽  
pp. 23403-23412 ◽  
Author(s):  
Tanping Li ◽  
Kiara Taylor-Edinbyrd ◽  
Revati Kumar
Keyword(s):  
Nitric Oxide ◽  
Sustained Release ◽  
Computational Study ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

Computational investigations into the effect of a copper based metal organic framework on the sustained release of NO from S-nitrosothiols.

Experimental and computational study of ethane and ethylene adsorption in the MIL-53(Al) metal organic framework

2016 ◽  
Vol 230 ◽  
pp. 154-165 ◽  
Author(s):  
Rui P.P.L. Ribeiro ◽  
Bárbara C.R. Camacho ◽  
Andriy Lyubchyk ◽  
Isabel A.A.C. Esteves ◽  
Fernando J.A.L. Cruz ◽  
...  
Keyword(s):  
Computational Study ◽  
Metal Organic Framework ◽  
Ethylene Adsorption ◽  
Metal Organic ◽  
Organic Framework

Enzyme-immobilized metal–organic framework nanosheets as tandem catalysts for the generation of nitric oxide

2018 ◽  
Vol 54 (79) ◽  
pp. 11176-11179 ◽  
Author(s):  
Pinghua Ling ◽  
Caihua Qian ◽  
Feng Gao ◽  
Jianping Lei
Keyword(s):  
Nitric Oxide ◽  
Metal Organic Framework ◽  
Serum Samples ◽  
Metal Organic ◽  
Organic Framework

An enzyme-immobilized metal–organic framework nanosystem was developed as a tandem catalyst for in situ generation of nitric oxide in serum samples.

A computational study of the catalytic aerobic epoxidation of propylene over the coordinatively unsaturated metal–organic framework Fe3(btc)2: formation of propylene oxide and competing reactions

2018 ◽  
Vol 20 (9) ◽  
pp. 6726-6734 ◽  
Author(s):  
Thana Maihom ◽  
Montree Sawangphruk ◽  
Michael Probst ◽  
Jumras Limtrakul
Keyword(s):  
Propylene Oxide ◽  
Density Functional Calculations ◽  
Density Functional ◽  
Computational Study ◽  
Metal Organic Framework ◽  
Epoxidation Of Propylene ◽  
Metal Organic ◽  
Competing Reactions ◽  
Organic Framework

The aerobic epoxidation of propylene over the metal–organic framework Fe3(btc)2 (btc = 1,3,5-benzentricarboxylate) as catalyst has been investigated by means of density functional calculations.

scholarly journals Investigation of Metal-Organic Framework-5 (MOF-5) as an Antitumor Drug Oridonin Sustained Release Carrier

Molecules ◽  
2019 ◽  
Vol 24 (18) ◽  
pp. 3369 ◽  
Author(s):  
Gongsen Chen ◽  
Juyuan Luo ◽  
Mengru Cai ◽  
Liuying Qin ◽  
Yibo Wang ◽  
...  
Keyword(s):  
Sustained Release ◽  
Anticancer Activity ◽  
Hepg2 Cells ◽  
Metal Organic Framework ◽  
Drug Carrier ◽  
Drug Loading ◽  
Addition Method ◽  
Direct Addition ◽  
Metal Organic ◽  
Organic Framework

Oridonin (ORI) is a natural active ingredient with strong anticancer activity. But its clinical use is restricted due to its poor water solubility, short half-life, and low bioavailability. The aim of this study is to utilize the metal organic framework material MOF-5 to load ORI in order to improve its release characteristics and bioavailability. Herein, MOF-5 was synthesized by the solvothermal method and direct addition method, and characterized by Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD), Fourier Transform Infrared Spectrometer (FTIR), Thermogravimetric Analysis (TG), Brunauer–Emmett–Teller (BET), and Dynamic Light Scattering (DLS), respectively. MOF-5 prepared by the optimal synthesis method was selected for drug-loading and in vitro release experiments. HepG2 cells were model cells. MTT assay, 4′,6-diamidino-2-phenylindole (DAPI) staining and Annexin V/PI assay were used to detect the biological safety of blank carriers and the anticancer activity of drug-loaded materials. The results showed that nano-MOF-5 prepared by the direct addition method had complete structure, uniform size and good biocompatibility, and was suitable as an ORI carrier. The drug loading of ORI@MOF-5 was 52.86% ± 0.59%. The sustained release effect was reliable, and the cumulative release rate was about 87% in 60 h. ORI@MOF-5 had significant cytotoxicity (IC50:22.99 μg/mL) and apoptosis effect on HepG2 cells. ORI@MOF-5 is hopeful to become a new anticancer sustained release preparation. MOF-5 has significant potential as a drug carrier material.

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