The Ireland–Claisen rearrangement strategy towards the synthesis of the schizophrenia drug, (+)-asenapine
2016 ◽
Vol 14
(4)
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pp. 1332-1337
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(±)-Asenapine, sold in the market as Saphris/Sycrest for the treatment of bipolar disorders, is synthesized in an optically pure form involving an Ireland–Claisen rearrangement as the key step. This approach allows access to all diastereomers.
2011 ◽
Vol 2011
(24)
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pp. 4571-4587
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1994 ◽
Vol 35
(40)
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pp. 7447-7450
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2001 ◽
Vol 74
(3)
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pp. 527-537
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Keyword(s):
2010 ◽
Vol 114
(4-5)
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pp. 184-194
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1991 ◽
Vol 56
(5)
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pp. 954-965
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Keyword(s):
1999 ◽
Vol 40
(33)
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pp. 6065-6068
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Keyword(s):