A Rapid and Simple Chromatographic Separation of Diastereomers of Silibinin and Their Oxidation to Produce 2,3-Dehydrosilybin Enantiomers in an Optically Pure Form

Planta Medica ◽  
2013 ◽  
Vol 79 (12) ◽  
pp. 1077-1080 ◽  
Author(s):  
Giovanni Di Fabio ◽  
Valeria Romanucci ◽  
Cinzia Di Marino ◽  
Lorenzo De Napoli ◽  
Armando Zarrelli
Keyword(s):  
Chromatographic Separation ◽  
Pure Form ◽  
Separation Of Diastereomers ◽  
Optically Pure

DETERMINATION OF MICRO-AMOUNTS OF 5β-PREGNAN-3α-OL-20-ONE IN URINE USING INFRARED-SPECTROMETRY

1962 ◽  
Vol 41 (2) ◽  
pp. 234-246 ◽  
Author(s):  
H. J. van der Molen
Keyword(s):  
Infrared Spectrum ◽  
Quantitative Determination ◽  
Acid Hydrolysis ◽  
Chromatographic Separation ◽  
Pure Form ◽  
Infrared Spectrometry ◽  
Hydrolysis Of

ABSTRACT A procedure for the quantitative determination of 5β-pregnan-3α-ol-20-one in urine is described. After acid hydrolysis of the pregnanolone-conjugates in urine, the free steroids are extracted with toluene. Pregnanolone is isolated in a pure form as its acetate; after chromatographic separation of the free steroids on alumina, the fraction containing pregnanolone is acetylated and rechromatographed on alumina. Quantitative determination of the isolated pregnanolone-acetate is carried out with the aid of the infrared spectrum recorded by a micro KBr-wafermethod. The reliability of the method under various conditions is discussed under the headings, specificity, accuracy, precision and sensitivity. It is possible to determine 30–40 μg pregnanolone in a 24-hours urine portion with a precision of 25%.

Synthesis and Properties of Planar-Chiral (η6-Benzene)(η5-cyclopentadienyl)ruthenium(II) Complexes in an Optically Pure Form

2001 ◽  
Vol 74 (3) ◽  
pp. 527-537 ◽  
Author(s):  
Yuji Matsushima ◽  
Nobuko Komatsuzaki ◽  
Yoshiki Ajioka ◽  
Mari Yamamoto ◽  
Hidetomo Kikuchi ◽  
...  
Keyword(s):  
Pure Form ◽  
Optically Pure

scholarly journals Concise Synthesis of Catechin Metabolites 5-(3′,4′-Dihydroxyphenyl)-γ-valerolactones (DHPV) in Optically Pure Form and Their Stereochemical Effects on Skin Wrinkle-Reducing Activities

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1970 ◽  
Author(s):  
Joonseong Hur ◽  
A-Ram Kim ◽  
Hyun Su Kim ◽  
Changjin Lim ◽  
Taewoo Kim ◽  
...  
Keyword(s):  
Pure Form ◽  
Synthetic Route ◽  
Enantiomerically Pure ◽  
Efficient Construction ◽  
Optically Pure

A concise and scalable synthetic route for optically pure (4S) and (4R)-5-(3′,4′-dihydroxyphenyl)-γ-valerolactones (DHPVs), catechin metabolites, has been developed via the efficient construction of a γ-valerolactone moiety from hexenol. Noticeably, the different skin wrinkle-reducing activities of each metabolite were revealed via our unique syntheses of DHPVs in an enantiomerically pure form.

The Ireland–Claisen rearrangement strategy towards the synthesis of the schizophrenia drug, (+)-asenapine

2016 ◽  
Vol 14 (4) ◽  
pp. 1332-1337 ◽  
Author(s):  
Raghunath Reddy Anugu ◽  
Prathama S. Mainkar ◽  
Balasubramanian Sridhar ◽  
Srivari Chandrasekhar
Keyword(s):  
Claisen Rearrangement ◽  
Bipolar Disorders ◽  
Pure Form ◽  
Optically Pure

(±)-Asenapine, sold in the market as Saphris/Sycrest for the treatment of bipolar disorders, is synthesized in an optically pure form involving an Ireland–Claisen rearrangement as the key step. This approach allows access to all diastereomers.

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