Synthesis and Properties of Planar-Chiral (η6-Benzene)(η5-cyclopentadienyl)ruthenium(II) Complexes in an Optically Pure Form

2001 ◽  
Vol 74 (3) ◽  
pp. 527-537 ◽  
Author(s):  
Yuji Matsushima ◽  
Nobuko Komatsuzaki ◽  
Yoshiki Ajioka ◽  
Mari Yamamoto ◽  
Hidetomo Kikuchi ◽  
...  
Keyword(s):  
Pure Form ◽  
Optically Pure

A Rapid and Simple Chromatographic Separation of Diastereomers of Silibinin and Their Oxidation to Produce 2,3-Dehydrosilybin Enantiomers in an Optically Pure Form

Planta Medica ◽  
2013 ◽  
Vol 79 (12) ◽  
pp. 1077-1080 ◽  
Author(s):  
Giovanni Di Fabio ◽  
Valeria Romanucci ◽  
Cinzia Di Marino ◽  
Lorenzo De Napoli ◽  
Armando Zarrelli
Keyword(s):  
Chromatographic Separation ◽  
Pure Form ◽  
Separation Of Diastereomers ◽  
Optically Pure

scholarly journals Concise Synthesis of Catechin Metabolites 5-(3′,4′-Dihydroxyphenyl)-γ-valerolactones (DHPV) in Optically Pure Form and Their Stereochemical Effects on Skin Wrinkle-Reducing Activities

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1970 ◽  
Author(s):  
Joonseong Hur ◽  
A-Ram Kim ◽  
Hyun Su Kim ◽  
Changjin Lim ◽  
Taewoo Kim ◽  
...  
Keyword(s):  
Pure Form ◽  
Synthetic Route ◽  
Enantiomerically Pure ◽  
Efficient Construction ◽  
Optically Pure

A concise and scalable synthetic route for optically pure (4S) and (4R)-5-(3′,4′-dihydroxyphenyl)-γ-valerolactones (DHPVs), catechin metabolites, has been developed via the efficient construction of a γ-valerolactone moiety from hexenol. Noticeably, the different skin wrinkle-reducing activities of each metabolite were revealed via our unique syntheses of DHPVs in an enantiomerically pure form.

The Ireland–Claisen rearrangement strategy towards the synthesis of the schizophrenia drug, (+)-asenapine

2016 ◽  
Vol 14 (4) ◽  
pp. 1332-1337 ◽  
Author(s):  
Raghunath Reddy Anugu ◽  
Prathama S. Mainkar ◽  
Balasubramanian Sridhar ◽  
Srivari Chandrasekhar
Keyword(s):  
Claisen Rearrangement ◽  
Bipolar Disorders ◽  
Pure Form ◽  
Optically Pure

(±)-Asenapine, sold in the market as Saphris/Sycrest for the treatment of bipolar disorders, is synthesized in an optically pure form involving an Ireland–Claisen rearrangement as the key step. This approach allows access to all diastereomers.

CD of primary amines and 1- or 3-substituted tetrahydroisoquinolines in presence of [Rh2(O2CCH3)4]

1991 ◽  
Vol 56 (5) ◽  
pp. 954-965 ◽  
Author(s):  
Wolfgang Diener ◽  
Jadwiga Frelek ◽  
Günter Snatzke
Keyword(s):  
Absolute Configuration ◽  
Nmr Spectra ◽  
Pure Form ◽  
Primary Amines ◽  
Methyl Groups ◽  
Optically Pure

The syntheses of (S)-(-)-1,2-dimethyl-1,2,3,4-tetrahydroisoquinoline (IX) and (S)-(+)-2,3-dimethyl-1,2,3,4-tetrahydroisoquinoline (XVI) [ via (S)-1-benzoyl-N-ethoxycarbonyl ethylamine (XI)] in optically pure form and with known absolute configuration is described. The CD and NMR spectra of these compounds and of most of their intermediates are given, and from these data could be deduced, that the N-methyl groups of the two bases IX and XVI adopt different conformations in solution, but the same (viz. axial) in their complexes with [Rh2(OAc)4].

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