In vitro study of a pH-sensitive multifunctional doxorubicin–gold nanoparticle system: therapeutic effect and surface enhanced Raman scattering

RSC Advances ◽  
2015 ◽  
Vol 5 (81) ◽  
pp. 65651-65659 ◽  
Author(s):  
Kate Y. J. Lee ◽  
Yiqing Wang ◽  
Shuming Nie
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticle ◽  
In Vitro Study ◽  
Ph Sensitive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Nanoparticle System ◽  
Enhanced Raman Scattering ◽  
Nanoparticle Drug Delivery

A pH-sensitive multifunctional doxorubicin–gold nanoparticle drug delivery system, which has the potential to detect and treat tumors, was developed.

scholarly journals Multiplexed Liquid Biopsy and Tumor Imaging Using Surface-Enhanced Raman Scattering

Biosensors ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 449
Author(s):  
Francesco Dell’Olio
Keyword(s):  
Raman Scattering ◽  
Single Molecule ◽  
Liquid Biopsy ◽  
Tumor Imaging ◽  
Surface Enhanced Raman Scattering ◽  
Detection Sensitivity ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

The recent improvements in diagnosis enabled by advances in liquid biopsy and oncological imaging significantly better cancer care. Both these complementary approaches, which are used for early tumor detection, characterization, and monitoring, can benefit from applying techniques based on surface-enhanced Raman scattering (SERS). With a detection sensitivity at the single-molecule level, SERS spectroscopy is widely used in cell and molecular biology, and its capability for the in vitro detection of several types of cancer biomarkers is well established. In the last few years, several intriguing SERS applications have emerged, including in vivo imaging for tumor targeting and the monitoring of drug release. In this paper, selected recent developments and trends in SERS applications in the field of liquid biopsy and tumor imaging are critically reviewed, with a special emphasis on results that demonstrate the clinical utility of SERS.

scholarly journals Optical Diagnostic Based on Functionalized Gold Nanoparticles

2019 ◽  
Vol 20 (18) ◽  
pp. 4346 ◽  
Author(s):  
Jiemei Ou ◽  
Zidan Zhou ◽  
Zhong Chen ◽  
Huijun Tan
Keyword(s):  
Optical Properties ◽  
Future Perspective ◽  
Au Nps ◽  
Optical Diagnostic ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Diagnostic Applications

Au nanoparticles (NPs) possess unique physicochemical and optical properties, showing great potential in biomedical applications. Diagnostic spectroscopy utilizing varied Au NPs has become a precision tool of in vitro and in vivo diagnostic for cancer and other specific diseases. In this review, we tried to comprehensively introduce the remarkable optical properties of Au NPs, including localized surfaces plasmon resonance (LSPR), surface-enhanced Raman scattering (SERS), and metal-enhanced fluorescence (MEF). Then, we highlighted the excellent works using Au NPs for optical diagnostic applications. Ultimately, the challenges and future perspective of using Au NPs for optical diagnostic were discussed.

Polarization Dependence of Surface-Enhanced Raman Scattering in Gold Nanoparticle−Nanowire Systems

Nano Letters ◽  
2008 ◽  
Vol 8 (8) ◽  
pp. 2497-2502 ◽  
Author(s):  
Hong Wei ◽  
Feng Hao ◽  
Yingzhou Huang ◽  
Wenzhong Wang ◽  
Peter Nordlander ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Gold Nanoparticle ◽  
Surface Enhanced Raman Scattering ◽  
Polarization Dependence ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Self-ordering Electrochemistry: A Simple Approach for Engineering Nanopore and Nanotube Arrays for Emerging Applications

2011 ◽  
Vol 64 (3) ◽  
pp. 294 ◽  
Author(s):  
Dusan Losic ◽  
Leonara Velleman ◽  
Krishna Kant ◽  
Tushar Kumeria ◽  
Karan Gulati ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Transport ◽  
Nanotube Arrays ◽  
Nanotube Membranes ◽  
Molecular Separation ◽  
Sensing Platform ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Interferometric Detection

In this paper, we present recent work from our group focussed on the fabrication of nanopore and nanotube arrays using self-ordered electrochemistry, and their application in several key areas including template synthesis, molecular separation, optical sensing, and drug delivery. We have fabricated nanoporous anodic aluminium oxide (AAO) with controlled pore dimensions (20–200 nm) and shapes, and used them as templates for the preparation of gold nanorod/nanotube arrays and gold nanotube membranes with characteristic properties such as surface enhanced Raman scattering and selective molecular transport. The application of AAO nanopores as a sensing platform for reflective interferometric detection is demonstrated. Finally, a drug release study on fabricated titania nanotubes confirms their potential for implantable drug delivery applications.

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