Assessment of two new nitrogen-rich tetrazine derivatives as high performance and safe energetic compounds

RSC Advances ◽  
2015 ◽  
Vol 5 (106) ◽  
pp. 87392-87399 ◽  
Author(s):  
M. H. Keshavarz ◽  
K. Esmaeilpour ◽  
M. Oftadeh ◽  
Y. Hayat Abadi
Keyword(s):  
High Performance ◽  
Energetic Compounds ◽  
Derivatives Of

This work introduces two novel nitrogen-rich derivatives of tetrazine, i.e. 1,2-bis (6-nitro-1,2,4,5-tetrazin-3-yl)diazene and 1,2-bis(6-nitro-1,2,4,5-tetrazin-3-yl)hydrazine, as high performance and safe energetic compounds.

Directed biosynthesis of novel derivatives of echinomycin. II. Purification and structure elucidation

1984 ◽  
Vol 30 (6) ◽  
pp. 730-738 ◽  
Author(s):  
D. Gauvreau ◽  
M. J. Waring
Keyword(s):  
High Performance ◽  
Reversed Phase ◽  
Aromatic Acids ◽  
Antibacterial Assay ◽  
New Antibiotics ◽  
Field Desorption Mass Spectrometry ◽  
Directed Biosynthesis ◽  
Phase Systems ◽  
Derivatives Of ◽  
Acid Precursor

New antibiotics produced by Streptomyces echinatus A8331 cultured in the presence of heterocyclic aromatic acids can be separated and purified by high-performance liquid chromatography using reversed phase columns. Natural quinoxaline antibiotics and certain quinoline derivatives can also be efficiently separated in normal phase systems. Details of purification procedures are described together with experiments to characterise the new antibiotics by field desorption mass spectrometry and proton magnetic resonance. Mono- and bis-substituted derivatives of echinomycin containing the following replacement chromophores have been isolated: 7-chloroquinoxaline-2-carbonyl, thieno[3,2-b]pyridine-5-carbonyl, and 6-methylquinoline-2-carbonyl. With a 6-methylquinoline-2-carboxylic acid precursor the analogues containing one or two replacement chromophores are each separable into two distinct components. One of the bis-substituted 6-methylquinoline products appears inactive in an antibacterial assay and behaves as a triostin analogue, presumably an immediate precursor of the corresponding echinomycin derivative.

Sign in / Sign up

Export Citation Format

Share Document