A family of mixed-ligand oxidovanadium(v) complexes with aroylhydrazone ligands: a combined experimental and computational study on the electronic effects of para substituents of hydrazone ligands on the electronic properties, DNA binding and nuclease activities

RSC Advances ◽  
2015 ◽  
Vol 5 (112) ◽  
pp. 92456-92472 ◽  
Author(s):  
Debashis Patra ◽  
Nirmalendu Biswas ◽  
Bhavini Kumari ◽  
Prolay Das ◽  
Nayim Sepay ◽  
...  
Keyword(s):  
Dna Binding ◽  
Electronic Properties ◽  
Computational Study ◽  
Nuclease Activity ◽  
Mixed Ligand ◽  
Electronic Effects ◽  
Binding Ability ◽  
Marked Influence ◽  
Hydrazone Ligands

Substituents at 5-position in the acetophenone ring of the hydrazone ligands in a family of mixed-ligand oxidovanadium(v) complexes show marked influence on the electronic properties, DNA binding ability and nuclease activity.

Fluorescent mixed ligand copper(ii) complexes of anthracene-appended Schiff bases: studies on DNA binding, nuclease activity and cytotoxicity

2015 ◽  
Vol 44 (26) ◽  
pp. 11997-12010 ◽  
Author(s):  
Paramasivam Jaividhya ◽  
Mani Ganeshpandian ◽  
Rajkumar Dhivya ◽  
Mohammad Abdulkadher Akbarsha ◽  
Mallayan Palaniandavar
Keyword(s):  
Dna Binding ◽  
Schiff Bases ◽  
Nuclease Activity ◽  
Mixed Ligand ◽  
Base Pairs ◽  
Dna Base ◽  
Dna Base Pairs

While the phen of [Cu(L1–L5)(phen)(ACN)]2+ partially inserts into DNA base pairs the anthracenyl moiety of L1–L5 interacts with DNA hydrophobically.

scholarly journals Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structure.

1994 ◽  
Vol 14 (11) ◽  
pp. 7557-7568 ◽  
Author(s):  
J Zuo ◽  
R Baler ◽  
G Dahl ◽  
R Voellmy
Keyword(s):  
Transcription Factor ◽  
Heat Stress ◽  
Heat Shock ◽  
Dna Binding ◽  
Hydrophobic Interactions ◽  
Coiled Coil ◽  
Heat Shock Transcription Factor ◽  
Single Amino Acid ◽  
Binding Ability ◽  
Heat Shock Element

Heat stress regulation of human heat shock genes is mediated by human heat shock transcription factor hHSF1, which contains three 4-3 hydrophobic repeats (LZ1 to LZ3). In unstressed human cells (37 degrees C), hHSF1 appears to be in an inactive, monomeric state that may be maintained through intramolecular interactions stabilized by transient interaction with hsp70. Heat stress (39 to 42 degrees C) disrupts these interactions, and hHSF1 homotrimerizes and acquires heat shock element DNA-binding ability. hHSF1 expressed in Xenopus oocytes also assumes a monomeric, non-DNA-binding state and is converted to a trimeric, DNA-binding form upon exposure of the oocytes to heat shock (35 to 37 degrees C in this organism). Because endogenous HSF DNA-binding activity is low and anti-hHSF1 antibody does not recognize Xenopus HSF, we employed this system for mapping regions in hHSF1 that are required for the maintenance of the monomeric state. The results of mutagenesis analyses strongly suggest that the inactive hHSF1 monomer is stabilized by hydrophobic interactions involving all three leucine zippers which may form a triple-stranded coiled coil. Trimerization may enable the DNA-binding function of hHSF1 by facilitating cooperative binding of monomeric DNA-binding domains to the heat shock element motif. This view is supported by observations that several different LexA DNA-binding domain-hHSF1 chimeras bind to a LexA-binding site in a heat-regulated fashion, that single amino acid replacements disrupting the integrity of hydrophobic repeats render these chimeras constitutively trimeric and DNA binding, and that LexA itself binds stably to DNA only as a dimer but not as a monomer in our assays.

Mixed ligand Ni(II) complexes: DNA binding, oxidative and photo-cleavage studies

2008 ◽  
Vol 7 (2) ◽  
pp. 97-107 ◽  
Author(s):  
M. C. Prabhakara ◽  
H. S. Bhojya Naik
Keyword(s):  
Dna Binding ◽  
Mixed Ligand ◽  
Photo Cleavage

scholarly journals Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability.

1991 ◽  
Vol 5 (10) ◽  
pp. 1902-1911 ◽  
Author(s):  
K D Sarge ◽  
V Zimarino ◽  
K Holm ◽  
C Wu ◽  
R I Morimoto
Keyword(s):  
Heat Shock ◽  
Dna Binding ◽  
Heat Shock Factors ◽  
Binding Ability
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