Asymmetric synthesis of functionalized trifluoromethyl-substituted pyrrolidines via an organocatalytic domino Michael/Mannich [3+2] cycloaddition

2016 ◽  
Vol 52 (97) ◽  
pp. 14011-14014 ◽  
Author(s):  
Ying Zhi ◽  
Kun Zhao ◽  
Qiang Liu ◽  
Ai Wang ◽  
Dieter Enders
Keyword(s):  
Asymmetric Synthesis ◽  
Trifluoromethyl Group ◽  
Stereogenic Centers

The asymmetric synthesis of highly functionalized pyrrolidine derivatives with three contiguous stereogenic centers and bearing a trifluoromethyl group has been developed through an organocatalytic domino Michael/Mannich [3+2] cycloaddition sequence.

Asymmetric Synthesis of Diphosphine Ligands Containing Phosphorus and Carbon Stereogenic Centers by Means of a Chiral Palladium Complex Promoted Hydrophosphination Reaction

2009 ◽  
Vol 48 (12) ◽  
pp. 5535-5539 ◽  
Author(s):  
Yi Zhang ◽  
Sumod A. Pullarkat ◽  
Yongxin Li ◽  
Pak-Hing Leung
Keyword(s):  
Asymmetric Synthesis ◽  
Palladium Complex ◽  
Diphosphine Ligands ◽  
Stereogenic Centers

Asymmetric Synthesis of Octahydrobenzofuran Core Structure with Three Contiguous Stereogenic Centers and Development of the Absolute Configurations

2013 ◽  
Vol 44 (1) ◽  
pp. 115-120 ◽  
Author(s):  
Muhammad Sohail ◽  
Yao-Feng Wang ◽  
Shaoxiang Wu ◽  
Wei Zeng ◽  
Fu-Xue Chen
Keyword(s):  
Asymmetric Synthesis ◽  
Core Structure ◽  
Stereogenic Centers ◽  
The Absolute

scholarly journals Advances on Greener Asymmetric Synthesis of Antiviral Drugs via Organocatalysis

2021 ◽  
Vol 14 (11) ◽  
pp. 1125
Author(s):  
Everton M. da Silva ◽  
Hérika D. A. Vidal ◽  
Arlene G. Corrêa
Keyword(s):  
Pharmaceutical Industry ◽  
Antiviral Activity ◽  
Asymmetric Synthesis ◽  
High Mortality ◽  
Viral Infections ◽  
Mortality Rates ◽  
Chiral Drugs ◽  
Stereogenic Centers ◽  
Synthetic Routes ◽  
New Compounds

Viral infections cause many severe human diseases, being responsible for remarkably high mortality rates. In this sense, both the academy and the pharmaceutical industry are continuously searching for new compounds with antiviral activity, and in addition, face the challenge of developing greener and more efficient methods to synthesize these compounds. This becomes even more important with drugs possessing stereogenic centers as highly enantioselective processes are required. In this minireview, the advances achieved to improve synthetic routes efficiency and sustainability of important commercially antiviral chiral drugs are discussed, highlighting the use of organocatalytic methods.

scholarly journals Advances on Greener Asymmetric Synthesis of Antiviral Drugs via Organocatalysis

2021 ◽  
Author(s):  
Arlene Gonçalves Corrêa ◽  
Everton Machado da Silva ◽  
Herika Danielle Almeida Vidal
Keyword(s):  
Pharmaceutical Industry ◽  
Antiviral Activity ◽  
Asymmetric Synthesis ◽  
High Mortality ◽  
Viral Infections ◽  
Mortality Rates ◽  
Chiral Drugs ◽  
Stereogenic Centers ◽  
Synthetic Routes ◽  
New Compounds

Viral infections inflict many serious human diseases, being responsible for remarkably high mortality rates. In this sense, both the academy and the pharmaceutical industry are continuously searching for new compounds with antiviral activity, and in addition, face the challenge of developing greener and more efficient methods to synthesize these compounds. This becomes even more important with drugs possessing stereogenic centers as highly enantioselective processes are required. In this minireview, the advances achieved to improve synthetic routes efficiency and sustainability of important commercially antiviral chiral drugs are discussed, highlighting the use of organocatalytic methods.

scholarly journals Synergistic Catalysis: Asymmetric Synthesis of Cyclopentanes Bearing Four Stereogenic Centers

Synthesis ◽  
2016 ◽  
Vol 49 (01) ◽  
pp. 167-174
Author(s):  
Ramon Rios ◽  
Kaiheng Zhang ◽  
Marta Meazza ◽  
Anabel Izaga ◽  
Clotilde Contamine ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Synergistic Catalysis ◽  
Stereogenic Centers

One-Pot Asymmetric Synthesis of β-Cyanohydroxymethyl α-Amino Acid Derivatives:  Formation of Three Contiguous Stereogenic Centers

2002 ◽  
Vol 4 (25) ◽  
pp. 4519-4522 ◽  
Author(s):  
Shin-ichi Watanabe ◽  
Armando Córdova ◽  
Fujie Tanaka ◽  
Carlos F. Barbas
Keyword(s):  
Amino Acid ◽  
Asymmetric Synthesis ◽  
Amino Acid Derivatives ◽  
One Pot ◽  
Stereogenic Centers

Asymmetric Synthesis of 2-Thiocyanato-2-(1-aminoalkyl)-substituted 1-Tetralones and 1-Indanones with Tetrasubstituted Carbon Stereogenic Centers via Cooperative Cation-Binding Catalysis

2017 ◽  
Vol 359 (11) ◽  
pp. 1879-1891 ◽  
Author(s):  
Lei Yu ◽  
Xiaoyan Wu ◽  
Mun Jong Kim ◽  
Venkataramasubramanian Vaithiyanathan ◽  
Yidong Liu ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Cation Binding ◽  
Stereogenic Centers ◽  
Substituted 1

Convergent Asymmetric Synthesis of a Renin Inhibitor: A Highly Efficient Construction Method of Three Stereogenic Centers

2013 ◽  
Vol 17 (11) ◽  
pp. 1430-1439 ◽  
Author(s):  
Makoto Michida ◽  
Yoshihiro Takayanagi ◽  
Makoto Imai ◽  
Yukito Furuya ◽  
Kenichi Kimura ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Construction Method ◽  
Renin Inhibitor ◽  
Highly Efficient ◽  
Stereogenic Centers ◽  
Efficient Construction

Thiourea-Catalyzed Domino Michael–Mannich [3+2] Cycloadditions: A Strategy for the Asymmetric Synthesis of 3,3′-Pyrrolidinyl-dispirooxindoles

Synlett ◽  
2017 ◽  
Vol 28 (20) ◽  
pp. 2876-2880 ◽  
Author(s):  
Ying Zhi ◽  
Kun Zhao ◽  
Carolina von Essen ◽  
Kari Rissanen ◽  
Dieter Enders
Keyword(s):  
Asymmetric Synthesis ◽  
Stereogenic Centers ◽  
Very High

The asymmetric synthesis of trifluoromethylated 3,3′-pyrrolidinyl-dispirooxindole derivatives with four contiguous stereogenic centers, including two vicinal spiro-stereocenters, is described. Employing a bifunctional thiourea catalyst, a domino Michael–Mannich [3+2] cycloaddition occurs readily between isatin ketimines and isatin-derived enoates with good yields and very high stereoselectivities, providing a direct entry to the title compounds of potential medical value.

ChemInform Abstract: Recyclable Organocatalyst-Promoted One-Pot Asymmetric Synthesis of Spirooxindoles Bearing Multiple Stereogenic Centers.

ChemInform ◽  
2016 ◽  
Vol 47 (18) ◽  
Author(s):  
Xin Huang ◽  
Kenny Pham ◽  
Wenbin Yi ◽  
Xiaofeng Zhang ◽  
Cecilia Clamens ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
One Pot ◽  
Stereogenic Centers
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