Simultaneous determination of entecavir and lamivudine in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study

RSC Advances ◽  
2016 ◽  
Vol 6 (75) ◽  
pp. 70990-70998 ◽  
Author(s):  
Qikun Jiang ◽  
Yan Liu ◽  
Yunjie Wang ◽  
Yinghua Sun ◽  
Bo Li ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Multiple Reaction Monitoring ◽  
Ultra Performance Liquid Chromatography ◽  
Rat Plasma ◽  
Tandem Mass ◽  
Reaction Monitoring ◽  
Chromatography Tandem Mass Spectrometry ◽  
Mode Method ◽  
Liquid Chromatography Tandem Mass

The study's aim is to develop and validate a rapid, selective and sensitive ultra-performance liquid chromatography-tandem mass spectrometry with multiple reaction monitoring (MRM) mode method for the simultaneous determination of entecavir and lamivudine in rat plasma.

Simultaneous determination of fipronil and its major metabolites in corn and soil by ultra-performance liquid chromatography-tandem mass spectrometry

2014 ◽  
Vol 6 (6) ◽  
pp. 1788-1795 ◽  
Author(s):  
Youpu Cheng ◽  
Fengshou Dong ◽  
Xingang Liu ◽  
Jun Xu ◽  
Wei Meng ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Simultaneous Determination ◽  
Ultra Performance Liquid Chromatography ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

A simple, quick, effective method was developed for the determination of fipronil and its three metabolites in soil and corn by ultra-performance liquid chromatography-tandem mass spectrometry.

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