scholarly journals Determination of spectral markers of cytotoxicity and genotoxicity using in vitro Raman microspectroscopy: cellular responses to polyamidoamine dendrimer exposure

The Analyst ◽  
2017 ◽  
Vol 142 (20) ◽  
pp. 3848-3856 ◽  
Author(s):  
Esen Efeoglu ◽  
Alan Casey ◽  
Hugh J. Byrne
Keyword(s):  
Cellular Responses ◽  
Raman Microspectroscopy ◽  
High Content Screening ◽  
Label Free ◽  
Polyamidoamine Dendrimer ◽  
Screening Technique

Raman microspectroscopy as anin vitrolabel-free, high content screening technique to determine spectral markers of cytogenotoxicity.

Label-free, high content screening using Raman microspectroscopy: the toxicological response of different cell lines to amine-modified polystyrene nanoparticles (PS-NH2)

The Analyst ◽  
2017 ◽  
Vol 142 (18) ◽  
pp. 3500-3513 ◽  
Author(s):  
Esen Efeoglu ◽  
Marcus A. Maher ◽  
Alan Casey ◽  
Hugh J. Byrne
Keyword(s):  
Multivariate Analysis ◽  
Cell Lines ◽  
Raman Microspectroscopy ◽  
High Content Screening ◽  
Label Free ◽  
Polystyrene Nanoparticles ◽  
Screening Technique ◽  
Cancerous Cell ◽  
Modified Polystyrene

Raman microspectroscopy as a ‘high content nanotoxicological screening technique’ with the aid of multivariate analysis, on non-cancerous and cancerous cell lines.

Label-Free Determination of the Cell Cycle Phase in Human Embryonic Stem Cells by Raman Microspectroscopy

2013 ◽  
Vol 85 (19) ◽  
pp. 8996-9002 ◽  
Author(s):  
Stanislav O. Konorov ◽  
H. Georg Schulze ◽  
James M. Piret ◽  
Michael W. Blades ◽  
Robin F. B. Turner
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Raman Microspectroscopy ◽  
Cell Cycle Phase ◽  
Cycle Phase ◽  
Label Free

Discrimination of normal and malignant mouse ovarian surface epithelial cells in vitro using Raman microspectroscopy

2015 ◽  
Vol 7 (22) ◽  
pp. 9520-9528 ◽  
Author(s):  
S. Borel ◽  
E. A. Prikryl ◽  
N. H. Vuong ◽  
J. Jonkman ◽  
B. Vanderhyden ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Multivariate Statistical Analysis ◽  
Raman Microspectroscopy ◽  
Live Cells ◽  
Label Free ◽  
Multivariate Statistical ◽  
Ovarian Surface Epithelial ◽  
Free Classification

Raman microspectroscopy in conjunction with multivariate statistical analysis is a powerful technique for label-free classification of live cells based on their molecular composition, which can be correlated to variations in protein, DNA/RNA, and lipid macromolecules.

Label-free determination of lipid composition and secondary protein structure of human salivary noncancerous and cancerous tissues by Raman microspectroscopy

The Analyst ◽  
2015 ◽  
Vol 140 (7) ◽  
pp. 2107-2113 ◽  
Author(s):  
Beata Brozek-Pluska ◽  
Monika Kopec ◽  
Izabela Niedzwiecka ◽  
Alina Morawiec-Sztandera
Keyword(s):  
Protein Structure ◽  
Cancer Detection ◽  
Lipid Composition ◽  
Raman Microspectroscopy ◽  
Spectroscopic Methods ◽  
Label Free ◽  
Secondary Protein Structure ◽  
Oncological Diagnostics

The applications of optical spectroscopic methods in cancer detection open new possibilities in oncological diagnostics.

Determination of in vitro „anti-aging„-effects of Ganoderma pfeifferi

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
W Jülich ◽  
J Pörksen ◽  
H Welzel ◽  
U Lindequist
Keyword(s):  
Aging Effects

In vitro determination of the skin anti-aging potential of eleven South African plants

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
GN Ndlovu ◽  
G Fouche ◽  
W Cordier ◽  
V Steenkamp ◽  
M Tselanyane
Keyword(s):  
South African ◽  
South African Plants ◽  
African Plants

A Molecular Approach to Immunoscintigraphy: A Study of the T-Antigen Conformation on the Surface of Tumors

1987 ◽  
Vol 26 (01) ◽  
pp. 1-6 ◽  
Author(s):  
S. Selvaraj ◽  
M. R. Suresh ◽  
G. McLean ◽  
D. Willans ◽  
C. Turner ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Tumor Cell ◽  
T Antigen ◽  
Human Carcinomas ◽  
Animal Tumor ◽  
Synthetic Antigens

The role of glycoconjugates in tumor cell differentiation has been well documented. We have examined the expression of the two anomers of the Thomsen-Friedenreich antigen on the surface of human, canine and murine tumor cell membranes both in vitro and in vivo. This has been accomplished through the synthesis of the disaccharide terminal residues in both a and ß configuration. Both entities were used to generate murine monoclonal antibodies which recognized the carbohydrate determinants. The determination of fine specificities of these antibodies was effected by means of cellular uptake, immunohistopathology and immunoscintigraphy. Examination of pathological specimens of human and canine tumor tissue indicated that the expressed antigen was in the β configuration. More than 89% of all human carcinomas tested expressed the antigen in the above anomeric form. The combination of synthetic antigens and monoclonal antibodies raised specifically against them provide us with invaluable tools for the study of tumor marker expression in humans and their respective animal tumor models.

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