Acid- and reduction-sensitive micelles for improving the drug delivery efficacy for pancreatic cancer therapy

2018 ◽  
Vol 6 (5) ◽  
pp. 1262-1270 ◽  
Author(s):  
Pu Wang ◽  
Jinxiu Wang ◽  
Haowen Tan ◽  
Shanfan Weng ◽  
Liying Cheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Solid Tumors ◽  
Anticancer Drugs ◽  
Therapeutic Efficacy ◽  
Anticancer Therapy ◽  
The Poor ◽  
Pancreatic Cancer Therapy

One of the major challenges in anticancer therapy is the poor penetration of anticancer drugs into tumors, especially in solid tumors, resulting in decreased therapeutic efficacy in vivo.

Comprehensively enhanced delivery cascade by transformable beaded nanofibrils for pancreatic cancer therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Qinglin Sheng ◽  
Ting Li ◽  
Xian Tang ◽  
Wei Zhao ◽  
Rong Guo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Tumor Therapy ◽  
Pancreatic Cancer Therapy ◽  
Delivery Efficiency ◽  
In Vivo Delivery

Facing the barriers in each step of the in vivo delivery cascade, the low drug delivery efficiency remains a thorny problem in tumor therapy. Although recently the nanofibril drug delivery...

Smart multifunctional drug delivery towards anticancer therapy harmonized in mesoporous nanoparticles

Nanoscale ◽  
2015 ◽  
Vol 7 (34) ◽  
pp. 14191-14216 ◽  
Author(s):  
Seonmi Baek ◽  
Rajendra K. Singh ◽  
Dipesh Khanal ◽  
Kapil D. Patel ◽  
Eun-Jung Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Drugs ◽  
Anticancer Therapy ◽  
Mesoporous Nanoparticles

Effectiveness of the delivery of anticancer drugs and the efficacy of cancer therapy can be enhanced using smart multifunctional mesoporous nanoparticles.

scholarly journals Functionalized MoS2 Nanosheets as Multi-Gene Delivery Vehicles for In Vivo Pancreatic Cancer Therapy

2018 ◽  
Vol 2 (4) ◽  
pp. 371-386 ◽  
Author(s):  
Feng Yin ◽  
Tommy Anderson ◽  
Nishtha Panwar ◽  
Kang Zhang ◽  
Swee Chuan Tjin ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Gene Delivery ◽  
Mos2 Nanosheets ◽  
Delivery Vehicles ◽  
Pancreatic Cancer Therapy ◽  
Gene Delivery Vehicles

Biodegradable nanoparticles as siRNA carriers for in vivo gene silencing and pancreatic cancer therapy

2017 ◽  
Vol 5 (18) ◽  
pp. 3327-3337 ◽  
Author(s):  
Guimiao Lin ◽  
Chih-Kuang Chen ◽  
Feng Yin ◽  
Chengbin Yang ◽  
Jinglin Tian ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Tumor Growth ◽  
Gene Silencing ◽  
Xenograft Model ◽  
Biodegradable Nanoparticles ◽  
Pancreatic Cancer Therapy

Biodegradable charged polyester-based vectors (BCPVs) were utilized for efficiently delivering mutatedK-Ras-targeting siRNA and successfully inhibiting tumor growth in a pancreatic xenograft modelin vivo.

scholarly journals MT1‐MMP‐Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy

2020 ◽  
Vol 7 (17) ◽  
pp. 1902746 ◽  
Author(s):  
Yan Wei ◽  
Sha Song ◽  
Nianxiu Duan ◽  
Feng Wang ◽  
Yuxi Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Blood Perfusion ◽  
Pancreatic Cancer Therapy

Protein corona in drug delivery for multimodal cancer therapy in vivo

Nanoscale ◽  
2018 ◽  
Vol 10 (5) ◽  
pp. 2461-2472 ◽  
Author(s):  
Eugenia Li Ling Yeo ◽  
Patricia Soo Ping Thong ◽  
Khee Chee Soo ◽  
James Chen Yong Kah
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Therapeutic Efficacy ◽  
Tumor Regression ◽  
Protein Corona ◽  
Mouse Serum ◽  
Complete Tumor Regression ◽  
Tumor Accumulation ◽  
Complete Tumor

Intravenous delivery of NR-MS-Ce6, wherein Ce6 was loaded on NRs using a protein corona formed from mouse serum, resulted in tumor accumulation and synergy between PTT and PDT, leading to enhanced therapeutic efficacy and complete tumor regression in 19 days.

scholarly journals Impacting Pancreatic Cancer Therapy in Heterotypic in Vitro Organoids and in Vivo Tumors with Specificity-Tuned, NIR-Activable Photoimmunonanoconjugates: Towards Conquering Desmoplasia?

Nano Letters ◽  
2019 ◽  
Vol 19 (11) ◽  
pp. 7573-7587 ◽  
Author(s):  
Girgis Obaid ◽  
Shazia Bano ◽  
Srivalleesha Mallidi ◽  
Mans Broekgaarden ◽  
Jerrin Kuriakose ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Pancreatic Cancer Therapy
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