scholarly journals Probing the excited-state chemical shifts and exchange parameters by nitrogen-decoupled amide proton chemical exchange saturation transfer (HNdec-CEST)

2017 ◽  
Vol 53 (61) ◽  
pp. 8541-8544 ◽  
Author(s):  
Qinglin Wu ◽  
Benjamin A. Fenton ◽  
Jessica L. Wojtaszek ◽  
Pei Zhou
Keyword(s):  
Excited State ◽  
Chemical Exchange ◽  
Chemical Shifts ◽  
Chemical Exchange Saturation Transfer ◽  
Amide Proton ◽  
Saturation Transfer ◽  
State Information ◽  
State Chemical ◽  
Exchange Parameters

The HNdec-CEST experiment enables robust extraction of excited-state information of macromolecules.

Dysprosium(III) and thulium(III) complexes of DO3A-monoanilides: an investigation of electronic effects on their relaxometric and amide-based PARACEST properties

2015 ◽  
Vol 93 (2) ◽  
pp. 244-252 ◽  
Author(s):  
Melissa M. Lewis ◽  
Mark Milne ◽  
Robert Bartha ◽  
Robert H.E. Hudson
Keyword(s):  
Magnetic Properties ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Amide Proton ◽  
Saturation Transfer ◽  
Ph Sensors ◽  
Electronic Effects ◽  
Alkaline Conditions ◽  
Electron Donating Groups ◽  
Potential Use

A series of 1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate monoamide (DO3A-monoanilide) complexes Dy3+ and Tm3+ were prepared and their magnetic properties evaluated in the context of their potential use as pH sensors. The ligands varied by para-substitution of the aniline moiety and represent electron-withdrawing and electron-donating groups. Only the Tm3+ complexes produced chemical exchange saturation transfer (CEST) spectra with CEST intensities due to the amide proton ranging from 1% to 8%. A maximum CEST signal was observed under slightly alkaline conditions (pH ∼8) when electron-donating groups were present, whereas the strongly electron-withdrawing nitro group produced a maximum CEST at neutral pH (pH = 7). The T1 and T2 relaxivities of the Dy3+ and Tm3+ complexes were also assessed. The T1 relaxivities of the Dy3+ and Tm3+ complexes were both low (r1 ≤ 0.3 mM−1 s−1, 25 °C, pH = 7) but, as expected, the Dy3+ complexes had much higher T2 relaxivities (r2 = 2–7 mM−1 s−1, 25 °C, pH = 7) as compared to the Tm3+-based chelates (r2 ≤ 0.09 mM−1 s−1, 25 °C, pH = 7).

scholarly journals Quantifying amide proton exchange rate and concentration in chemical exchange saturation transfer imaging of the human brain

NeuroImage ◽  
2019 ◽  
Vol 189 ◽  
pp. 202-213 ◽  
Author(s):  
Hye-Young Heo ◽  
Zheng Han ◽  
Shanshan Jiang ◽  
Michael Schär ◽  
Peter C.M. van Zijl ◽  
...  
Keyword(s):  
Exchange Rate ◽  
Human Brain ◽  
Chemical Exchange ◽  
Proton Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Amide Proton ◽  
Saturation Transfer ◽  
Amide Proton Exchange

Systematic Evaluation of Amide Proton Chemical Exchange Saturation Transfer at 3 T

2016 ◽  
Vol 51 (10) ◽  
pp. 635-646 ◽  
Author(s):  
Holger Schmidt ◽  
Nina F. Schwenzer ◽  
Sergios Gatidis ◽  
Thomas Küstner ◽  
Konstantin Nikolaou ◽  
...  
Keyword(s):  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Amide Proton ◽  
Systematic Evaluation ◽  
Saturation Transfer
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