Synthesis, spectroscopic investigation, and DFT study of N,N′-disubstituted ferrocene-based thiourea complexes as potent anticancer agents

2018 ◽  
Vol 47 (6) ◽  
pp. 1868-1878 ◽  
Author(s):  
Faiza Asghar ◽  
Saira Fatima ◽  
Sadaf Rana ◽  
Amin Badshah ◽  
Ian S. Butler ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Binding Affinity ◽  
Anticancer Agents ◽  
Spectroscopic Investigation ◽  
Dft Study ◽  
Redox Potentials ◽  
Dna Binding Affinity ◽  
Dna Binders ◽  
Homo Lumo

The DNA binding affinity of ferrocenyl thioureas (A1–A9) explored by CV and UV ascertain them as noble DNA binders. The complexes also publicized decent antioxidant and anticancer activity. DFT-based HOMO/LUMO energies are comparable with experimentally calculated redox potentials.

Biologically active halo-substituted ferrocenyl thioureas: synthesis, spectroscopic characterization, and DFT calculations

2018 ◽  
Vol 42 (9) ◽  
pp. 7154-7165 ◽  
Author(s):  
Faiza Asghar ◽  
Sadaf Rana ◽  
Saira Fatima ◽  
Amin Badshah ◽  
Bhajan Lal ◽  
...  
Keyword(s):  
Dna Binding ◽  
Dft Calculations ◽  
Binding Affinity ◽  
Spectroscopic Characterization ◽  
Biologically Active ◽  
Dna Binding Affinity ◽  
Dna Binders

The DNA binding affinity of ferrocenyl complexes explored by CV and UV ascertain them as noble DNA binders. The computational measurements correlate well with the outcomes of electrochemistry and bio-activities.

Synthesis, DNA binding affinity and anticancer activity of novel 4H-benzo[g][1,2,3]triazolo[5,1-c][1,4]oxazocines

2016 ◽  
Vol 14 (39) ◽  
pp. 9294-9305 ◽  
Author(s):  
K. N. Visweswara Sastry ◽  
Sunitha Rani Routhu ◽  
Soma Gupta Datta ◽  
Narayana Nagesh ◽  
Bathini Nagendra Babu ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Binding Affinity ◽  
Cancer Therapeutics ◽  
New Class ◽  
Dna Binding Affinity

Cancer therapeutics: a new class of anticancer heterocycles was synthesized.

Solid-phase synthesis of new pyrrolobenzodiazepine–chalcone conjugates: DNA-binding affinity and anticancer activity

2008 ◽  
Vol 18 (7) ◽  
pp. 2434-2439 ◽  
Author(s):  
Ahmed Kamal ◽  
N. Shankaraiah ◽  
S. Prabhakar ◽  
Ch. Ratna Reddy ◽  
N. Markandeya ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Binding Affinity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Dna Binding Affinity

Synthesis, characterization, solution equilibria, DFT study, DNA binding affinity and cytotoxic properties of a cobalt(II) complex with a 5-pyrazolone ligand

2018 ◽  
Vol 482 ◽  
pp. 738-748 ◽  
Author(s):  
Selma Akcha ◽  
Santiago Gómez-Ruiz ◽  
Safia Kellou-Tairi ◽  
Luis Lezama ◽  
Frank Blanco Pérez ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Affinity ◽  
Dft Study ◽  
Solution Equilibria ◽  
Dna Binding Affinity

DNA-binding affinity and anticancer activity of β-carboline–chalcone conjugates as potential DNA intercalators: Molecular modelling and synthesis

2015 ◽  
Vol 59 ◽  
pp. 130-139 ◽  
Author(s):  
Nagula Shankaraiah ◽  
K.P. Siraj ◽  
Shalini Nekkanti ◽  
Vunnam Srinivasulu ◽  
Pankaj Sharma ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Binding Affinity ◽  
Molecular Modelling ◽  
Dna Intercalators ◽  
Dna Binding Affinity

5-Methyl-Benzofuro[3,2-b]quinoline Derivatives as DNA Binders

2013 ◽  
Vol 711 ◽  
pp. 73-78 ◽  
Author(s):  
Rui Fang Zhang ◽  
Rui Rui Zhang ◽  
Yu Jing Lu ◽  
Zhi Yun Du ◽  
Cheng Jie Fu ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Dna Binding ◽  
Binding Affinity ◽  
Binding Mode ◽  
Quinoline Derivatives ◽  
Lead Compound ◽  
Dna Binding Affinity ◽  
Intercalation Binding ◽  
Dna Binders ◽  
Derivatives Of

Several derivatives of 5-methyl-benzofuro [3,2-quinoline (O-isostere of cryptolepine) were synthesized. Spectrometric experiments and molecular modeling indicated that these derivatives interacted with duplex DNA by intercalation binding mode. The derivatives with aniline substituent exhibited superior DNA binding affinity to that of lead compound 5-methyl-benzofuro [3,2-quinoline.

Remarkable DNA binding affinity and potential anticancer activity of pyrrolo[2,1-c][1,4]benzodiazepine–naphthalimide conjugates linked through piperazine side-armed alkane spacers

2008 ◽  
Vol 16 (15) ◽  
pp. 7218-7224 ◽  
Author(s):  
Ahmed Kamal ◽  
R. Ramu ◽  
Venkatesh Tekumalla ◽  
G.B. Ramesh Khanna ◽  
Madan S. Barkume ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Binding Affinity ◽  
Dna Binding Affinity

Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing ‘click’ chemistry: DNA-binding affinity and anticancer activity

2008 ◽  
Vol 18 (4) ◽  
pp. 1468-1473 ◽  
Author(s):  
Ahmed Kamal ◽  
N. Shankaraiah ◽  
V. Devaiah ◽  
K. Laxma Reddy ◽  
Aarti Juvekar ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Click Chemistry ◽  
Binding Affinity ◽  
Dna Binding Affinity
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