An environmentally benign double Michael addition reaction of heterocyclic ketene aminals with quinone monoketals for diastereoselective synthesis of highly functionalized morphan derivatives in water

2017 ◽  
Vol 19 (15) ◽  
pp. 3574-3584 ◽  
Author(s):  
Yu-Lu Ma ◽  
Kai-Min Wang ◽  
Rong Huang ◽  
Jun Lin ◽  
Sheng-Jiao Yan
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Environmentally Benign ◽  
Diastereoselective Synthesis ◽  
Michael Addition Reaction ◽  
One Pot ◽  
Ketene Aminals

This effort involved an efficient and concise one-pot procedure for the synthesis of morphans based on quinone monoketals 1 reacting with HKAs 2.

Efficient Synthesis of 3-Amino-1,5-benzodiazepine-2-one Derivatives

Synlett ◽  
2017 ◽  
Vol 28 (10) ◽  
pp. 1183-1186 ◽  
Author(s):  
Nobuhiro Obara ◽  
Takeshi Watanabe ◽  
Tomohiro Asakawa ◽  
Toshiyuki Kan ◽  
Takao Tanaka
Keyword(s):  
Michael Addition ◽  
Convenient Method ◽  
Addition Reaction ◽  
Efficient Synthesis ◽  
Michael Addition Reaction ◽  
One Pot ◽  
Simple Method ◽  
The Michael Addition

A convenient method for synthesizing 3-amino-1,5-benzodiazepine-2-one via the Michael addition reaction of o-phenylenediamine with dehydroalanine ester derivatives, followed by cyclization, was developed. This simple method was used to obtain a variety of N-substituted 3-amino-1,5-benzodiazepine-2-ones in one pot with good yields.

Access to 3-Arylindoles through a Tandem One-Pot Protocol Involving Dearomatization, a Regioselective Michael Addition Reaction, and Rearomatization

2014 ◽  
Vol 2014 (12) ◽  
pp. 2565-2575 ◽  
Author(s):  
Santhosh Kumar Chittimalla ◽  
Chennakesavulu Bandi ◽  
Sireesha Putturu ◽  
Rajesh Kuppusamy ◽  
Kevin Christopher Boellaard ◽  
...  
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Michael Addition Reaction ◽  
One Pot

Diastereoselective synthesis of pitavastatin calcium via bismuth-catalyzed two-component hemiacetal/oxa-Michael addition reaction

2015 ◽  
Vol 13 (38) ◽  
pp. 9813-9819 ◽  
Author(s):  
Fangjun Xiong ◽  
Haifeng Wang ◽  
Lingjie Yan ◽  
Lingjun Xu ◽  
Yuan Tao ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Michael Addition ◽  
Addition Reaction ◽  
Diastereoselective Synthesis ◽  
Michael Addition Reaction ◽  
Two Component ◽  
Pitavastatin Calcium

An efficient and concise asymmetric synthesis of pitavastatin calcium (1) starting from commercially available (S)-epichlorohydrin is described.

Pyridine-grafted graphene oxide: a reusable acid–base bifunctional catalyst for the one-pot synthesis of β-phosphonomalonates via a cascade Knoevenagel–phospha Michael addition reaction in water

RSC Advances ◽  
2015 ◽  
Vol 5 (117) ◽  
pp. 96532-96538 ◽  
Author(s):  
Sara Sobhani ◽  
Farzaneh Zarifi
Keyword(s):  
Graphene Oxide ◽  
Michael Addition ◽  
Addition Reaction ◽  
Bifunctional Catalyst ◽  
Michael Addition Reaction ◽  
Acid Base ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One ◽  
Reaction In Water

Py–GO as a new acid–base bifunctional catalyst was synthesized and employed for the one-pot synthesis of β-phosphonomalonates in water.

Facile one‐pot, three‐component synthesis of novel bis(heterocycles) incorporating thieno[2,3‐ b ]thiophenes via Michael addition reaction

2020 ◽  
Vol 57 (5) ◽  
pp. 2243-2255 ◽  
Author(s):  
Elshimaa M. Eid ◽  
Huwaida M. E. Hassaneen ◽  
Ismail A. Abdelhamid ◽  
Ahmed H. M. Elwahy
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Michael Addition Reaction ◽  
One Pot
Sign in / Sign up

Export Citation Format

Share Document