Fabrication and characterization of a 3D bioprinted nanoparticle-hydrogel hybrid device for biomimetic detoxification

Nanoscale ◽  
2017 ◽  
Vol 9 (38) ◽  
pp. 14506-14511 ◽  
Author(s):  
Maggie S. Chen ◽  
Yue Zhang ◽  
Liangfang Zhang
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Hybrid Device ◽  
Red Blood Cell Membrane ◽  
Coated Nanoparticles ◽  
Fabrication And Characterization

We report a 3D-bioprinted micro/nanodevice that encapsulates red blood cell membrane-coated nanoparticles with inner channels for biodetoxification.

scholarly journals Size Dependency of Circulation and Biodistribution of Biomimetic Nanoparticles: Red Blood Cell Membrane-Coated Nanoparticles

Cells ◽  
2019 ◽  
Vol 8 (8) ◽  
pp. 881 ◽  
Author(s):  
Haichun Li ◽  
Kai Jin ◽  
Man Luo ◽  
Xuejun Wang ◽  
Xiaowen Zhu ◽  
...  
Keyword(s):  
Particle Size ◽  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Biomedical Applications ◽  
Immune Modulation ◽  
Red Blood Cell Membrane ◽  
Coated Nanoparticles ◽  
Biomimetic Nanoparticles

Recently, biomimetic nanoparticles, especially cell membrane-cloaked nanoparticles, have attracted increasing attention in biomedical applications, including antitumor therapy, detoxification, and immune modulation, by imitating the structure and the function of biological systems such as long circulation life in the blood. However, the circulation time of cell membrane-cloaked nanoparticles is far less than that of the original cells, greatly limiting their biomedical applications, while the underlying reasons are seldom demonstrated. In this study, the influence of particle size on the circulation and the biodistribution of red blood cell membrane-coated nanoparticles (RBC-NPs) as model biomimetic nanoparticles were investigated. Differently sized RBC-NPs (80, 120, 160, and 200 nm) were prepared by fusing RBC membranes on poly(lactic-co-glycolic acid) nanoparticles. It was shown that the particle size did not change the cellular uptake of these biomimetic nanoparticles by macrophage cells in vitro and their immunogenic responses in vivo. However, their circulation life in vivo decreased with the particle size, while their accumulation in the liver increased with the particle size, which might be related to their size-dependent filtration through hepatic sinusoids. These findings will provide experimental evidence for the design and the optimization of biomimetic nanoparticles.

Further characterization of cation channels present in the chicken red blood cell membrane

2008 ◽  
Vol 73 (2) ◽  
pp. 129-136 ◽  
Author(s):  
Franck Lapaix ◽  
Guillaume Bouyer ◽  
Serge Thomas ◽  
Stéphane Egée
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cation Channels ◽  
Red Blood Cell Membrane

Molecular and Biocompatibility Characterization of Red Blood Cell Membrane Targeted and Cell-Penetrating-Peptide-Modified Polymeric Nanoparticles

2017 ◽  
Vol 14 (7) ◽  
pp. 2224-2235 ◽  
Author(s):  
Kaustuv Sahoo ◽  
Sriharsha Karumuri ◽  
Rangika S. Hikkaduwa Koralege ◽  
Nicholas H. Flynn ◽  
Steve Hartson ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Polymeric Nanoparticles ◽  
Cell Penetrating Peptide ◽  
Red Blood Cell Membrane ◽  
Cell Penetrating
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